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CYNARIN

Product Name
CYNARIN
CAS No.
19870-46-3
Chemical Name
CYNARIN
Synonyms
19870-46-3 CYNARIN;1,3-Dicaffeoylquinic acid;Dicaffeoylquinic Acid, 1,5-;1,5-Dicaffeoylquinic acid-RM;1,5-di-O-Caffeoylquinic acid;(1S,3R,4R,5R)-1,3-O-Dicaffeoylquinic acid;(1S,3R,4R,5R)-1,3-Bis[3-(3,4-dihydroxyphenyl)acryloyloxy]-4,5-dihydroxycyclohexanecarboxylic acid;(1S,3R,4R,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylicaci;(1S,3R,4R,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylic acid;Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-
CBNumber
CB02457303
Molecular Formula
C25H24O12
Formula Weight
516.45
MOL File
19870-46-3.mol
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CYNARIN Property

Boiling point:
819.9±65.0 °C(Predicted)
Density 
1?+-.0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
soluble5mg/mL, clear, colorless to light yellow
form 
Solid
pka
2.50±0.50(Predicted)
color 
white to off-white
Stability:
Hygroscopic
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL82221
Product name
1,5-Dicaffeoylquinic acid
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$539
Updated
2024/03/01
Sigma-Aldrich
Product number
16917
Product name
1,5-Dicaffeoylquinic acid
Purity
analytical standard
Packaging
5mg
Price
$659
Updated
2022/05/15
Cayman Chemical
Product number
25050
Product name
1,5-Dicaffeoylquinic Acid
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
25050
Product name
1,5-Dicaffeoylquinic Acid
Purity
≥98%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
25050
Product name
1,5-Dicaffeoylquinic Acid
Purity
≥98%
Packaging
10mg
Price
$249
Updated
2024/03/01
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CYNARIN Chemical Properties,Usage,Production

Description

1,5-Dicaffeoylquinic acid (1,5-DCQA) has been found in A. montana and is an HIV-1 integrase inhibitor and free radical scavenger. 1,5-DCQA inhibits HIV-1 integrase 3'' end processing, end joining, and disintegration with IC50 values of 0.35, 0.56, and 0.84 μg/ml, respectively. It also inhibits HIV-1 replication in MT-2 T lymphoblastoid cells with an ED50value of 2 μg/ml. 1,5-DCQA (0.25-1 μM) reduces the level of free radicals released from human polymorphonuclear (PMN) cells stimulated by N-formyl-Met-Leu-Phe (fMLP; ) in a dose-dependent manner. It also dose-dependently increases cell survival and glutathione (GSH) levels and decreases reactive oxygen species (ROS) production and lactate dehydrogenase (LDH) release in an oxygen-glucose deprivation/reperfusion assay in rat cerebral astrocytes when used at concentrations ranging from 5 to 100 μM.

Uses

1,5-Dicaffeoylquinic Acid acts as an anti-hyperlipidemic agent. In addition, acts as a neuroprotective agent against amyloid-β toxicity in the treatement of Alzheimer’s.

CYNARIN Preparation Products And Raw materials

Raw materials

Preparation Products

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CYNARIN Suppliers

China 105 Germany 1 India 1 United Kingdom 2 United States 13 Global 122
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View Lastest Price from CYNARIN manufacturers

Shanghai Standard Technology Co., Ltd.
Product
1,5-Dicaffeoylquinic acid 19870-46-3
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-11-28
Career Henan Chemical Co
Product
CYNARIN 19870-46-3
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-13

19870-46-3, CYNARINRelated Search:

Cynarin Isochlorogenic Acid B Cryptochlorogenic acid CAFTARIC ACID 1-Caffeoylquinic acid Isochlorogenic acid A Chlorogenic acid 1,3,5-Tricaffeoylquinic acid Isochlorogenic acid C 2,3,4,5-Tetracaffeoyl-D-Glucaric acid Neochlorogenic acid

  • 1,3-Dicaffeoylquinic acid
  • (1S,3R,4R,5R)-1,3-Bis[3-(3,4-dihydroxyphenyl)acryloyloxy]-4,5-dihydroxycyclohexanecarboxylic acid
  • Dicaffeoylquinic Acid, 1,5-
  • (1S,3R,4R,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylic acid
  • 1,5-di-O-Caffeoylquinic acid
  • Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-
  • (1S,3R,4R,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylicaci
  • 19870-46-3 CYNARIN
  • (1S,3R,4R,5R)-1,3-O-Dicaffeoylquinic acid
  • CYNARIN|||Cyclohexanecarboxyli?c acid, 1,?3-?bis[[3-?(3,?4-?dihydroxyphenyl)?-?1-?oxo-?2-?propen-?1-?yl]?oxy]?-?4,?5-?dihydroxy-?, (1S,?3R,?4R,?5R)?-|||1,3-O-Dicaffeoylquinic acid|||1,5-Dicaffeoylquinic acid
  • 1,5-Dicaffeoylquinic acid-RM
  • 19870-46-3
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract