5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER
- Product Name
- 5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER
- CAS No.
- 129477-21-0
- Chemical Name
- 5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER
- Synonyms
- 5-BroMo-2-Methylnicotini;Ethyl 5-broMo-2-Methylnicotinate;Ethyl 5-bromo-2-methylnicotinate 97+%;5-BroMo-2-Methylnicotinic acid ethyl esther;5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER;Ethyl 5-bromo-2-methylpyridin-3-carboxylate;ethyl 5-broMo-2-Methylpyridine-3-carboxylate;5-Bromo-2-methylnicotinic acid ethyl ester ,98%;5-Bromo-2-methyl-3-pyridinecarboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 5-broMo-2-Methyl-, ethyl ester
- CBNumber
- CB02459307
- Molecular Formula
- C9H10BrNO2
- Formula Weight
- 244.09
- MOL File
- 129477-21-0.mol
5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER Property
- Boiling point:
- 263℃
- Density
- 1.439
- Flash point:
- 113℃
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Solid
- pka
- 1.66±0.20(Predicted)
- color
- Pale yellow
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C9H10BrNO2/c1-3-13-9(12)8-4-7(10)5-11-6(8)2/h4-5H,3H2,1-2H3
- InChIKey
- QVKPPFGWQMCQCI-UHFFFAOYSA-N
- SMILES
- C1(C)=NC=C(Br)C=C1C(OCC)=O
- CAS DataBase Reference
- 129477-21-0
Safety
- Safety Statements
- 24/25
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- E900465
- Product name
- Ethyl5-bromo-2-methylnicotinate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 124826
- Product name
- 5-Bromo-2-methylnicotinicacidethylester
- Purity
- 95+%
- Packaging
- 1g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- OR51975
- Product name
- Ethyl5-bromo-2-methylnicotinate
- Purity
- 97+%
- Packaging
- 5g
- Price
- $192
- Updated
- 2021/12/16
- Product number
- 4H58-9-2V
- Product name
- Ethyl 5-bromo-2-methylnicotinate
- Packaging
- 5G
- Price
- $212
- Updated
- 2021/12/16
- Product number
- J96693
- Product name
- Ethyl5-bromo-2-methylnicotinate
- Packaging
- 10g
- Price
- $300
- Updated
- 2021/12/16
5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Uses
Ethyl 5-bromo-2-methylnicotinate is used as a pharmaceutical intermediate.
Synthesis
To a 250 mL triple-necked flask were added sequentially 4. 9 g of methyl 5-bromo-2-methylnicotinate ( 0. 04 mol), anhydrous ethanol 40 mL, the corresponding amount of concentrated sulfuric acid, and phase transfer catalyst; a stirrer and a distillation apparatus were installed separately. Heat with stirring, gradually increase the temperature, evaporate the ethanol to the required liquid temperature, stop heating, natural cooling, about . 50?? C. It is poured out, and the reactants are white solids at room temperature. Neutralize the product with saturated aqueous sodium carbonate to a pH of about 7 (some solid sodium carbonate may be added if the volume is too large) and extract with 20 of chloroform. mL of chloroform, the combined organic layers were transferred to a reduced-pressure distillation flask, the chloroform was recovered at atmospheric pressure and then ethyl 5-bromo-2-methylnicotinate was distilled at reduced pressure, and the 92- to fraction was collected at 1. 06 kPa. The fraction was collected at 1.06 kPa from 92 to , weighed and the yield was calculated.
5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER manufacturers
- Product
- 5-Bromo-2-methylnicotinic acid ethyl ester 129477-21-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-Bromo-2-methylnicotinic acid ethyl ester 129477-21-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 5-BROMO-2-METHYL-NICOTINIC ACID ETHYL ESTER 129477-21-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24