Ethyl 5-bromonicotinate

Product Name: Ethyl 5-bromonicotinate
CAS No.: 20986-40-7
Chemical Name: Ethyl 5-bromonicotinate
Synonyms: AURORA KA-3028;5-Bromonicotinate;TIMTEC-BB SBB005820;5-broMo-ethyl sMoke;yl 5-broMonicotinate;Ethyl 5-bromonicotite;ETHYL 5-BROMONICOTINATE;Ethyl5-Bromonicotinate>Ethyl-5-Bromonicotinate98%;Ethyl 5-bromonicotinate,99%
CBNumber: CB8360117
Molecular Formula: C8H8BrNO2
Formula Weight: 230.06
MOL File: 20986-40-7.mol

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Ethyl 5-bromonicotinate Property

Melting point:: 39-42 °C
Boiling point:: 86-92°C 0,5mm
Density: 1.501±0.06 g/cm3(Predicted)
Flash point:: 86-92°C/0.5mm
storage temp.: Inert atmosphere,2-8°C
pka: 0.94±0.20(Predicted)
form: solid
color: Red/brown
BRN: 131473
InChI: InChI=1S/C8H8BrNO2/c1-2-12-8(11)6-3-7(9)5-10-4-6/h3-5H,2H2,1H3
InChIKey: PCPIANOJERKFJI-UHFFFAOYSA-N
SMILES: C1=NC=C(Br)C=C1C(OCC)=O
CAS DataBase Reference: 20986-40-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26-3637/39
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS003122
Product name: Ethyl 5-bromonicotinate
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 500 mg
Price: $73.1
Updated: 2025/07/31

TCI Chemical

Product number: E0866
Product name: Ethyl 5-Bromonicotinate
Purity: >98.0%(GC)
Packaging: 5g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: E0866
Product name: Ethyl 5-Bromonicotinate
Purity: >98.0%(GC)
Packaging: 25g
Price: $133
Updated: 2025/07/31

TRC

Product number: E919013
Product name: Ethyl 5-Bromonicotinate
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: OR5075
Product name: Ethyl 5-Bromonicotinate
Purity: 98%
Packaging: 100g
Price: $109
Updated: 2021/12/16

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Ethyl 5-bromonicotinate Chemical Properties,Usage,Production

Chemical Properties

white crystal powder

Uses

Ethyl 5-bromonicotinate is used as a key starting material for the preparation of 5-bromonicotinic acid hydrazide via reaction with a hydrazine hydrate.

Application

Ethyl 5-bromonicotinate is a carboxylate derivative and can be used as a pharmaceutical intermediate.

Synthesis

20826-04-4

64-17-5

20986-40-7

a) Synthesis of ethyl 5-bromonicotinate: Concentrated H2SO4 (9.0 mL) was slowly added dropwise to an ethanol (30.0 mL) suspension of 5-bromonicotinic acid (3.00 g, 14.9 mmol) under stirring, with the dropwise addition time controlled over 5 minutes until a clarified solution was formed. Subsequently, the reaction mixture was heated to reflux for 22 hours. Upon completion of the reaction, it was cooled to room temperature and the reaction was quenched with water (30 mL) and then extracted with dichloromethane (75 mL). The organic layer was washed sequentially with 10% Na2CO3 solution (20 mL) and water (20 mL), dried over anhydrous MgSO4, and concentrated by filtration through a sintered glass funnel to give 2.8 g of ethyl 5-bromonicotinate as a white solid in 82% yield. The structure of the product was confirmed by 1H NMR (CDCl3): δ 9.13 (d, J = 1.7 Hz, 1H), 8.84 (d, J = 2.2 Hz, 1H), 8.42 (m, J = 2.2, 1.7 Hz, 2H), 4.40 (q, J = 7.1 Hz, 2H), 1.43 (t, J = 7.1 Hz, 3H).

References

[1] Patent: WO2008/151073, 2008, A1. Location in patent: Page/Page column 39-40; 44
[2] Journal of Organic Chemistry, 2001, vol. 66, # 12, p. 4115 - 4121
[3] Patent: US2016/375131, 2016, A1. Location in patent: Paragraph 0080
[4] ACS Combinatorial Science, 2017, vol. 19, # 5, p. 286 - 298
[5] Organic Preparations and Procedures International, 1992, vol. 24, # 2, p. 143 - 146

Ethyl 5-bromonicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 5-bromonicotinate Suppliers

Americas 1 Austria 1 Belgium 3 China 208 Europe 3 France 1 Germany 7 India 21 Japan 3 Russia 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 16 United States 41 Global 310

Shanghai EachChem Co., Ltd.

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Energy Chemical

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Shijiazhuang Sdyano Fine Chemical Co., Ltd.

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Wuhan Chemwish Technology Co., Ltd

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Capot Chemical Co., Ltd

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View Lastest Price from Ethyl 5-bromonicotinate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Ethyl 5-bromonicotinate 20986-40-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-14

Shanghai Rlavie Technology Co ltd

Product: Ethyl 5-bromonicotinate 20986-40-7
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2021-12-31

Honest Joy Holdings Limited

Product: Ethyl 5-bromonicotinate 20986-40-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.6%
Supply Ability: 100 tons
Release date: 2022-01-26

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20986-40-7

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