ChemicalBook > CAS DataBase List > Ethyl 5-bromonicotinate
Ethyl 5-bromonicotinate
- Product Name
- Ethyl 5-bromonicotinate
- CAS No.
- 20986-40-7
- Chemical Name
- Ethyl 5-bromonicotinate
- Synonyms
- AURORA KA-3028;5-Bromonicotinate;TIMTEC-BB SBB005820;5-broMo-ethyl sMoke;yl 5-broMonicotinate;Ethyl 5-bromonicotite;ETHYL 5-BROMONICOTINATE;Ethyl5-Bromonicotinate>Ethyl-5-Bromonicotinate98%;Ethyl 5-bromonicotinate,99%
- CBNumber
- CB8360117
- Molecular Formula
- C8H8BrNO2
- Formula Weight
- 230.06
- MOL File
- 20986-40-7.mol
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Ethyl 5-bromonicotinate Property
- Melting point:
- 39-42 °C
- Boiling point:
- 86-92°C 0,5mm
- Density
- 1.501±0.06 g/cm3(Predicted)
- Flash point:
- 86-92°C/0.5mm
- storage temp.
- Inert atmosphere,2-8°C
- pka
- 0.94±0.20(Predicted)
- form
- solid
- color
- Red/brown
- BRN
- 131473
- InChI
- InChI=1S/C8H8BrNO2/c1-2-12-8(11)6-3-7(9)5-10-4-6/h3-5H,2H2,1H3
- InChIKey
- PCPIANOJERKFJI-UHFFFAOYSA-N
- SMILES
- C1=NC=C(Br)C=C1C(OCC)=O
- CAS DataBase Reference
- 20986-40-7(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 37/39-26-3637/39
- HazardClass
- IRRITANT
- HS Code
- 29333990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- CDS003122
- Product name
- Ethyl 5-bromonicotinate
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 500 mg
- Price
- $73.1
- Updated
- 2025/07/31
TCI Chemical
- Product number
- E0866
- Product name
- Ethyl 5-Bromonicotinate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $30
- Updated
- 2025/07/31
TCI Chemical
- Product number
- E0866
- Product name
- Ethyl 5-Bromonicotinate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $133
- Updated
- 2025/07/31
TRC
- Product number
- E919013
- Product name
- Ethyl 5-Bromonicotinate
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR5075
- Product name
- Ethyl 5-Bromonicotinate
- Purity
- 98%
- Packaging
- 100g
- Price
- $109
- Updated
- 2021/12/16
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Ethyl 5-bromonicotinate Chemical Properties,Usage,Production
Chemical Properties
white crystal powder
Uses
Ethyl 5-bromonicotinate is used as a key starting material for the preparation of 5-bromonicotinic acid hydrazide via reaction with a hydrazine hydrate.
Application
Ethyl 5-bromonicotinate is a carboxylate derivative and can be used as a pharmaceutical intermediate.
Synthesis
20826-04-4
64-17-5
20986-40-7
a) Synthesis of ethyl 5-bromonicotinate: Concentrated H2SO4 (9.0 mL) was slowly added dropwise to an ethanol (30.0 mL) suspension of 5-bromonicotinic acid (3.00 g, 14.9 mmol) under stirring, with the dropwise addition time controlled over 5 minutes until a clarified solution was formed. Subsequently, the reaction mixture was heated to reflux for 22 hours. Upon completion of the reaction, it was cooled to room temperature and the reaction was quenched with water (30 mL) and then extracted with dichloromethane (75 mL). The organic layer was washed sequentially with 10% Na2CO3 solution (20 mL) and water (20 mL), dried over anhydrous MgSO4, and concentrated by filtration through a sintered glass funnel to give 2.8 g of ethyl 5-bromonicotinate as a white solid in 82% yield. The structure of the product was confirmed by 1H NMR (CDCl3): δ 9.13 (d, J = 1.7 Hz, 1H), 8.84 (d, J = 2.2 Hz, 1H), 8.42 (m, J = 2.2, 1.7 Hz, 2H), 4.40 (q, J = 7.1 Hz, 2H), 1.43 (t, J = 7.1 Hz, 3H).
References
[1] Patent: WO2008/151073, 2008, A1. Location in patent: Page/Page column 39-40; 44
[2] Journal of Organic Chemistry, 2001, vol. 66, # 12, p. 4115 - 4121
[3] Patent: US2016/375131, 2016, A1. Location in patent: Paragraph 0080
[4] ACS Combinatorial Science, 2017, vol. 19, # 5, p. 286 - 298
[5] Organic Preparations and Procedures International, 1992, vol. 24, # 2, p. 143 - 146
Ethyl 5-bromonicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 5-bromonicotinate manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- Ethyl 5-bromonicotinate 20986-40-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-14
Shanghai Rlavie Technology Co ltd
- Product
- Ethyl 5-bromonicotinate 20986-40-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2021-12-31
Honest Joy Holdings Limited
- Product
- Ethyl 5-bromonicotinate 20986-40-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.6%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
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