(3,3-DIFLUOROCYCLOBUTYL)METHANOL
- Product Name
- (3,3-DIFLUOROCYCLOBUTYL)METHANOL
- CAS No.
- 681128-39-2
- Chemical Name
- (3,3-DIFLUOROCYCLOBUTYL)METHANOL
- Synonyms
- (3,3-Difluorocyclobutyl)m...;3,3-Difluoro-cyclobutanemethanol;(3,3-DIFLUOROCYCLOBUTYL)METHANOL;CyclobutaneMethanol, 3,3-difluoro-
- CBNumber
- CB02465928
- Molecular Formula
- C5H8F2O
- Formula Weight
- 122.11
- MOL File
- 681128-39-2.mol
(3,3-DIFLUOROCYCLOBUTYL)METHANOL Property
- Boiling point:
- 130.9±10.0 °C(Predicted)
- Density
- 1.2g/ml
- refractive index
- 1.40
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- clear liquid
- pka
- 15.05±0.10(Predicted)
- color
- Colorless to Almost colorless
- InChI
- InChI=1S/C5H8F2O/c6-5(7)1-4(2-5)3-8/h4,8H,1-3H2
- InChIKey
- MDZKTVVUZBIKGI-UHFFFAOYSA-N
- SMILES
- C1(CO)CC(F)(F)C1
Safety
- HS Code
- 2905599890
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SYX00114
- Product name
- (3,3-Difluorocyclobutyl)methanol
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- D5582
- Product name
- (3,3-Difluorocyclobutyl)methanol
- Purity
- >98.0%(GC)
- Packaging
- 200mg
- Price
- $61
- Updated
- 2025/07/31
- Product number
- D5582
- Product name
- (3,3-Difluorocyclobutyl)methanol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $245
- Updated
- 2025/07/31
- Product number
- D445545
- Product name
- (3,3-Difluorocyclobutyl)methanol
- Packaging
- 1g
- Price
- $265
- Updated
- 2021/12/16
- Product number
- AS51105
- Product name
- 3,3-Difluorocyclobutane-1-methanol
- Purity
- 97+%
- Packaging
- 5G
- Price
- $329
- Updated
- 2021/12/16
(3,3-DIFLUOROCYCLOBUTYL)METHANOL Chemical Properties,Usage,Production
Uses
(3,3-Difluorocyclobutyl)methanol is an intermediate used to prepare diaminoalkane aspartic protease inhibitors.
Synthesis
107496-54-8
681128-39-2
Step 1: Synthesis of (3,3-difluorocyclobutyl)methanol Sodium borohydride (0.556 g, 14.70 mmol) was suspended in tetrahydrofuran (50 mL) and cooled to 0 °C. The methanol was then added to the mixture of sodium borohydride (0.556 g, 14.70 mmol). Subsequently, a solution of 3,3-difluorocyclobutanecarboxylic acid (2 g, 14.70 mmol) in tetrahydrofuran (50 mL) was added dropwise. After the dropwise addition, the reaction flask was removed from the ice bath and the reaction was stirred for 1 hour at room temperature. After that, the reaction mixture was cooled again to 0 °C and boron trifluoride-ether compound (1.862 mL, 14.70 mmol) was slowly added. The reaction was stirred at 0 °C overnight and gradually warmed up to room temperature. After completion of the reaction, the mixture was cooled again to 0 °C and the reaction was quenched with 95% ethanol (25 mL). After stirring in an ice bath for 1 h, the mixture was concentrated in vacuum. The residue was partitioned with dichloromethane and saturated saline and the organic phase was separated. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo to afford the title compound (3,3-difluorocyclobutyl) methanol as a light tan oil (1.629 g, 9% yield). 1H NMR (300 MHz, CDCl3) δ: 2.31-2.38 (m, 3H), 2.60-2.66 (m, 2H), 3.67 (m, 2H); MS (DCI) m/z: 123 (M+H)+.
References
[1] Patent: WO2015/112445, 2015, A1. Location in patent: Page/Page column 162; 163
[2] Patent: US2016/376240, 2016, A1. Location in patent: Paragraph 0683
[3] Patent: WO2012/7869, 2012, A2. Location in patent: Page/Page column 85
[4] Patent: US2012/10183, 2012, A1. Location in patent: Page/Page column 40
[5] Patent: US2009/105306, 2009, A1. Location in patent: Page/Page column 32
(3,3-DIFLUOROCYCLOBUTYL)METHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
(3,3-DIFLUOROCYCLOBUTYL)METHANOL Suppliers
- Tel
- 0512-63009836 18994340901
- Fax
- 0512-63006936
- helen@struchem.com
- Country
- China
- ProdList
- 3981
- Advantage
- 60
- Tel
- 15716293042 18862996710
- Fax
- 0513-68015394
- 15050603958@163.com
- Country
- China
- ProdList
- 694
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 0519-89803565 13776850645
- Fax
- 0519-89803575
- info4@huanlingchem.com
- Country
- China
- ProdList
- 891
- Advantage
- 68
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7892
- Advantage
- 64
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- +86-25-68710855, +86-25-68710897
- Fax
- 025-68710856
- sales@springpharma.net
- Country
- China
- ProdList
- 1261
- Advantage
- 62
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 027-88041443 13072715837
- Fax
- 027-51829379
- sales@hetero-chem.com
- Country
- China
- ProdList
- 696
- Advantage
- 58
View Lastest Price from (3,3-DIFLUOROCYCLOBUTYL)METHANOL manufacturers
- Product
- (3,3-DIFLUOROCYCLOBUTYL)METHANOL 681128-39-2
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2019-12-25