3,3-Difluorocyclobutanecarboxylic acid
Uses- Product Name
- 3,3-Difluorocyclobutanecarboxylic acid
- CAS No.
- 107496-54-8
- Chemical Name
- 3,3-Difluorocyclobutanecarboxylic acid
- Synonyms
- 3,3-Difluoro-cyclobutanec...;3-Difluorocyclobutanecarboxylic acid;3,3-Difluorocyclobutanecarboxylic acid;Cyclobutanecarboxylic acid, 3,3-difluoro-;3,3-Difluorocyclobutanecarboxylic acid 98%;3,3-Difluorocyclobutanecarboxylic Acid(WXFC0148);TIANFU-CHEM 107496-54-8 3,3-Difluorocyclobutanecarboxylic acid
- CBNumber
- CB8966436
- Molecular Formula
- C5H6F2O2
- Formula Weight
- 136.1
- MOL File
- 107496-54-8.mol
3,3-Difluorocyclobutanecarboxylic acid Property
- Melting point:
- 51.0 to 55.0 °C
- Boiling point:
- 205 °C
- Density
- 1.37
- Flash point:
- 78 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 3.63±0.40(Predicted)
- color
- White to Light yellow
- InChI
- InChI=1S/C5H6F2O2/c6-5(7)1-3(2-5)4(8)9/h3H,1-2H2,(H,8,9)
- InChIKey
- PLRCVBKYFLWAAT-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)CC(F)(F)C1
Safety
- RIDADR
- UN 3261 8/PG III
- WGK Germany
- 3
- HazardClass
- IRRITANT
- PackingGroup
- III
- HS Code
- 2916200090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- MNO000127
- Product name
- 3,3-Difluoro-cyclobutanecarboxylic acid
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $286
- Updated
- 2025/07/31
- Product number
- D5225
- Product name
- 3,3-Difluorocyclobutanecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 200mg
- Price
- $41
- Updated
- 2025/07/31
- Product number
- D5225
- Product name
- 3,3-Difluorocyclobutanecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $118
- Updated
- 2025/07/31
- Product number
- D447593
- Product name
- 3,3-Difluorocyclobutanecarboxylic Acid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- PC400716
- Product name
- 3,3-Difluorocyclobutanecarboxylic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
3,3-Difluorocyclobutanecarboxylic acid Chemical Properties,Usage,Production
Uses
3,3-Difluorocyclobutane carboxylic acid is used as an organic and pharmaceutical intermediate.
Synthesis Reference(s)
Synthetic Communications, 35, p. 657, 2005 DOI: 10.1081/SCC-200050350
Synthesis
935273-86-2
107496-54-8
General procedure for the synthesis of 3,3-difluorocyclobutanecarboxylic acid from benzyl ester of 3,3-difluorocyclobutanecarboxylate: benzyl ester of 3,3-difluorocyclobutanecarboxylic acid (0.84 g, 3.72 mmol) was dissolved in ethanol (40 mL), and about 0.02 g of palladium/activated carbon catalyst was added. The reaction mixture was stirred at room temperature for 12 hours in a hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad. The filtrate was concentrated and dried under vacuum to afford the target product 3,3-difluorocyclobutanecarboxylic acid (0.46 g, 90% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.16-2.55 (m, 5H).
References
[1] Patent: WO2013/107405, 2013, A1. Location in patent: Page/Page column 42
[2] Patent: US2015/87600, 2015, A1. Location in patent: Page/Page column
[3] Patent: EP3290418, 2018, A1. Location in patent: Paragraph 0172; 0181
[4] Patent: US9273058, 2016, B2. Location in patent: Page/Page column 337; 338
[5] Patent: WO2007/47625, 2007, A2. Location in patent: Page/Page column 24
3,3-Difluorocyclobutanecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,3-Difluorocyclobutanecarboxylic acid manufacturers
- Product
- 3,3-Difluorocyclobutanecarboxylic acid 107496-54-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-09
- Product
- 3,3-Difluorocyclobutanecarboxylic acid 107496-54-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 3,3-Difluorocyclobutanecarboxylic acid 107496-54-8
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04