3,3-Difluorocyclobutanecarboxylic acid

Uses

Product Name: 3,3-Difluorocyclobutanecarboxylic acid
CAS No.: 107496-54-8
Chemical Name: 3,3-Difluorocyclobutanecarboxylic acid
Synonyms: 3,3-Difluoro-cyclobutanec...;3-Difluorocyclobutanecarboxylic acid;3,3-Difluorocyclobutanecarboxylic acid;Cyclobutanecarboxylic acid, 3,3-difluoro-;3,3-Difluorocyclobutanecarboxylic acid 98%;3,3-Difluorocyclobutanecarboxylic Acid(WXFC0148);TIANFU-CHEM 107496-54-8 3,3-Difluorocyclobutanecarboxylic acid
CBNumber: CB8966436
Molecular Formula: C5H6F2O2
Formula Weight: 136.1
MOL File: 107496-54-8.mol

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3,3-Difluorocyclobutanecarboxylic acid Property

Melting point:: 51.0 to 55.0 °C
Boiling point:: 205 °C
Density: 1.37
Flash point:: 78 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 3.63±0.40(Predicted)
color: White to Light yellow
InChI: InChI=1S/C5H6F2O2/c6-5(7)1-3(2-5)4(8)9/h3H,1-2H2,(H,8,9)
InChIKey: PLRCVBKYFLWAAT-UHFFFAOYSA-N
SMILES: C1(C(O)=O)CC(F)(F)C1

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Safety

RIDADR: UN 3261 8/PG III
WGK Germany: 3
HazardClass: IRRITANT
PackingGroup: III
HS Code: 2916200090
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Dermal
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: MNO000127
Product name: 3,3-Difluoro-cyclobutanecarboxylic acid
Purity: Aldrich
Packaging: 1g
Price: $286
Updated: 2025/07/31

TCI Chemical

Product number: D5225
Product name: 3,3-Difluorocyclobutanecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 200mg
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: D5225
Product name: 3,3-Difluorocyclobutanecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $118
Updated: 2025/07/31

TRC

Product number: D447593
Product name: 3,3-Difluorocyclobutanecarboxylic Acid
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Apolloscientific

Product number: PC400716
Product name: 3,3-Difluorocyclobutanecarboxylic acid
Purity: 98%
Packaging: 5g
Price: $84
Updated: 2021/12/16

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3,3-Difluorocyclobutanecarboxylic acid Chemical Properties,Usage,Production

Uses

3,3-Difluorocyclobutane carboxylic acid is used as an organic and pharmaceutical intermediate.

Synthesis Reference(s)

Synthetic Communications, 35, p. 657, 2005 DOI: 10.1081/SCC-200050350

Synthesis

935273-86-2

107496-54-8

General procedure for the synthesis of 3,3-difluorocyclobutanecarboxylic acid from benzyl ester of 3,3-difluorocyclobutanecarboxylate: benzyl ester of 3,3-difluorocyclobutanecarboxylic acid (0.84 g, 3.72 mmol) was dissolved in ethanol (40 mL), and about 0.02 g of palladium/activated carbon catalyst was added. The reaction mixture was stirred at room temperature for 12 hours in a hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad. The filtrate was concentrated and dried under vacuum to afford the target product 3,3-difluorocyclobutanecarboxylic acid (0.46 g, 90% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.16-2.55 (m, 5H).

References

[1] Patent: WO2013/107405, 2013, A1. Location in patent: Page/Page column 42
[2] Patent: US2015/87600, 2015, A1. Location in patent: Page/Page column
[3] Patent: EP3290418, 2018, A1. Location in patent: Paragraph 0172; 0181
[4] Patent: US9273058, 2016, B2. Location in patent: Page/Page column 337; 338
[5] Patent: WO2007/47625, 2007, A2. Location in patent: Page/Page column 24

3,3-Difluorocyclobutanecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3,3-Difluorocyclobutanecarboxylic acid Suppliers

Americas 1 China 200 Europe 1 India 4 Japan 1 United Kingdom 2 United States 18 Global 227

BTC Pharmaceutical CO. Ltd

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ANHUI JINGKE BIOTECHNOLOGY CO.,LTD

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J & K SCIENTIFIC LTD.

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Energy Chemical

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Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

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Tetranov Biopharm

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View Lastest Price from 3,3-Difluorocyclobutanecarboxylic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 3,3-Difluorocyclobutanecarboxylic acid 107496-54-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3,3-Difluorocyclobutanecarboxylic acid 107496-54-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 3,3-Difluorocyclobutanecarboxylic acid 107496-54-8
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-04

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3,3-Difluorocyclobutanecarboxylic Acid(WXFC0148)

3,3-Difluorocyclobutanecarboxylic acid 98%

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TIANFU-CHEM 107496-54-8 3,3-Difluorocyclobutanecarboxylic acid

107496-54-8