ChemicalBook > CAS DataBase List > 3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE
3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE
- Product Name
- 3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE
- CAS No.
- 637031-93-7
- Chemical Name
- 3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE
- Synonyms
- 3,3-difluorocyclobutan-1-aMine hydrochloride;3,3-difluorocyclobutanaMine hcl;3,3-Difluorocyclobutanami...;(3,3-difluorocyclobutyl)azanium;3,3-Difluoro-cyclobutylamine HCl salt;3,3-DIFLUOROCYCLOBUTAMINE HYDROCHLORIDE;3,3-Diflurocyclobutanamine hydrochloride;3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE;3,3-difluorocyclobutanamine'hydrochloride;(3,3-Difluorocyclobutyl)aMine Hydrochloride
- CBNumber
- CB51517113
- Molecular Formula
- C4H8ClF2N
- Formula Weight
- 143.56
- MOL File
- 637031-93-7.mol
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3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE Property
- Melting point:
- 296 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C4H7F2N.ClH/c5-4(6)1-3(7)2-4;/h3H,1-2,7H2;1H
- InChIKey
- WLXXTHPAORBNIG-UHFFFAOYSA-N
- SMILES
- FC1(CC(N)C1)F.Cl
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- D5597
- Product name
- 3,3-Difluorocyclobutanamine Hydrochloride
- Packaging
- 200MG
- Price
- $31
- Updated
- 2025/07/31
TCI Chemical
- Product number
- D5597
- Product name
- 3,3-Difluorocyclobutanamine Hydrochloride
- Packaging
- 1G
- Price
- $94
- Updated
- 2025/07/31
TRC
- Product number
- D445980
- Product name
- 3,3-Difluorocyclobutanamine Hydrochloride
- Packaging
- 5g
- Price
- $120
- Updated
- 2021/12/16
TRC
- Product number
- D445980
- Product name
- 3,3-Difluorocyclobutanamine Hydrochloride
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 068653
- Product name
- 3,3-Difluorocyclobutanamine hydrochloride
- Purity
- >95%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
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3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
3-Halo substituted cyclobutanamine used in the preparation of piperazinyl antiviral agents as well as kinase inhibitors.
Uses
3,3-Difluorocyclobutanamine hydrochloride is used in the preparation of piperazinyl antiviral agents as well as kinase inhibitors.
Synthesis
939399-53-8
637031-93-7
Step C: Synthesis of 3,3-difluorocyclobutylamine hydrochloride. A mixture of benzyl (3,3-difluorocyclobutyl)carbamate (1.47 g, 6.1 mmol) and 10% Pd/C (1 g) in methanol (20 mL) was subjected to a hydrogen atmosphere (1 atm) and stirred overnight at room temperature. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad and washed with methanol. Concentrated hydrochloric acid (2 mL) was added to the filtrate, followed by evaporation of the solvent under vacuum to afford the target product 3,3-difluorocyclobutanamine hydrochloride (0.8 g, 85% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.60 (m, 3H), 3.64 (m, 1H), 2.89 (m, 4H).
References
[1] Patent: WO2012/9678, 2012, A1. Location in patent: Page/Page column 210
[2] Patent: US2013/303524, 2013, A1. Location in patent: Paragraph 0413-0414
3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE Suppliers
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View Lastest Price from 3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 3,3-difluorocyclobutanamine hydrochloride （Ivosidenib Intermediate） 637031-93-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-09
Shaanxi Haibo Biotechnology Co., Ltd
- Product
- 3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE 637031-93-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-31
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 3,3-difluorocyclobutanamine hydrochloride 637031-93-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
637031-93-7, 3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDERelated Search:
Methyl 3,3-difluoro-cyclo...
3,3-Difluorocyclobutanecarboxylic acid
3-aminocyclobutanol(SALTDATA: FREE)
Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester (9CI)
Cyclobutanamine, 3,3-difluoro- (9CI)
TERT-BUTYL 3,3-DIFLUOROCYCLOBUTANECARBOXYLATE
3-Aminocyclobutanone hydrochloride
3-Aminocyclobutanol hydrochloride
(3,3-DIFLUOROCYCLOBUTYL)METHANOL
3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE
CHEMPACIFIC 43424