1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE
- Product Name
- 1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE
- CAS No.
- 66684-61-5
- Chemical Name
- 1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE
- Synonyms
- 2,4-Difluoro-6-methoxynitrobenzene;1,5-Difluoro-3-Methoxy-2-nitro-benz;1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE;Benzene, 1,5-difluoro-3-Methoxy-2-nitro-;1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE ISO 9001：2015 REACH;3,5-Difluoro-2-nitroanisole【1,5-Difluoro-3-methoxy-2-nitrobenzene】;1,5-Difluoro-3-methoxy-2-nitrobenzene, 3,5-Difluoro-2-nitrophenyl methyl ether
- CBNumber
- CB02466763
- Molecular Formula
- C7H5F2NO3
- Formula Weight
- 189.12
- MOL File
- 66684-61-5.mol
1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE Property
- Boiling point:
- 238℃
- Density
- 1.414
- Flash point:
- 98℃
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2909309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D451958
- Product name
- 1,5-Difluoro-3-methoxy-2-nitrobenzene
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4654-3-76
- Product name
- 3,5-Difluoro-2-nitroanisole
- Packaging
- 1g
- Price
- $112
- Updated
- 2021/12/16
- Product number
- PC7672
- Product name
- 3,5-Difluoro-2-nitroanisole
- Packaging
- 250mg
- Price
- $18
- Updated
- 2021/12/16
- Product number
- 4654-3-76
- Product name
- 3,5-Difluoro-2-nitroanisole
- Packaging
- 250mg
- Price
- $29
- Updated
- 2021/12/16
- Product number
- PC7672
- Product name
- 3,5-Difluoro-2-nitroanisole
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE Chemical Properties,Usage,Production
Synthesis
93343-10-3
66684-61-5
1. 3,5-difluoroanisole (30 g, 208 mmol) was dissolved in 260 mL of dichloromethane at 0 °C. 2. Fuming nitric acid (60 mL) at a concentration of greater than 90% was added slowly and dropwise to the above solution. 3. The reaction mixture was kept stirred at 0 °C for 3 h. 4. After completion of the reaction, the reaction mixture was washed with water. 5. The aqueous phase was extracted with dichloromethane. 6. The organic phases were combined and washed with brine, followed by drying with magnesium sulfate.7. The dried organic phase was concentrated on a rotary evaporator.8. The residue was recrystallized by solvent mixing of hexane and ethyl acetate to afford 28.5 g (72% yield) of 1,5-difluoro-3-methoxy-2-nitrobenzene, the product being an off-white powder.1H NMR (400 MHz, DMSO) δ ppm: 7.20 (m, 2H), 3.91 (s, 3H).
References
[1] Patent: US2009/143367, 2009, A1. Location in patent: Page/Page column 30
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 21, p. 7621 - 7638
1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,5-DIFLUORO-3-METHOXY-2-NITRO-BENZENE manufacturers
- Product
- 3,5-Difluoro-2-nitroanisole 66684-61-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%+
- Supply Ability
- 100 tons
- Release date
- 2020-01-13
- Product
- 1,5-Difluoro-3-methoxy-2-nitrobenzene 66684-61-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-09