ChemicalBook > CAS DataBase List > tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

Product Name
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
CAS No.
1181816-12-5
Chemical Name
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
Synonyms
tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-carboxylate;2-Boc-6-oxo-2-azaspiro[3....;6-oxo-2-azaspiro[3.3]hept...;2-Boc-6-oxo-2-azaspiro[3.3]heptane;6-oxo-2-azaspiro[3.3]heptane-2-carboxyL;tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-ca;ert-Butyl6-oxo-2-azaspiro[3.3]heptane-2-carboxylate;Tert-butyl-6-oxo-2-azaspiro[3,3]heptane-2-carxylate;tert-Butyl 7-oxo-2-azaspiro[3.4]octane-2-carboxylate;tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
CBNumber
CB02470890
Molecular Formula
C11H17NO3
Formula Weight
211.26
MOL File
1181816-12-5.mol
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tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Property

Melting point:
114.5-116 °C
Boiling point:
314.7±42.0 °C(Predicted)
Density 
1.16±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-0.93±0.20(Predicted)
form 
solid
color 
Pale yellow
InChI
InChI=1S/C11H17NO3/c1-10(2,3)15-9(14)12-6-11(7-12)4-8(13)5-11/h4-7H2,1-3H3
InChIKey
HQHRAGXKFOTSQE-UHFFFAOYSA-N
SMILES
C1C2(CC(=O)C2)CN1C(OC(C)(C)C)=O
CAS DataBase Reference
1181816-12-5
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

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N-Bromosuccinimide Price

TRC
Product number
B809410
Product name
tert-​Butyl6-​Oxo-​2-​azaspiro[3.3]​heptane-​2-​carboxylate
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
B809410
Product name
tert-​Butyl6-​Oxo-​2-​azaspiro[3.3]​heptane-​2-​carboxylate
Packaging
500mg
Price
$165
Updated
2021/12/16
TRC
Product number
B809410
Product name
tert-​Butyl6-​Oxo-​2-​azaspiro[3.3]​heptane-​2-​carboxylate
Packaging
2.5g
Price
$605
Updated
2021/12/16
Apolloscientific
Product number
OR308105
Product name
tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
Packaging
1g
Price
$141
Updated
2021/12/16
Matrix Scientific
Product number
070594
Product name
6-Oxo-2-azaspiro[3.3]heptane-2-carboxylicacid tert-butyl ester
Purity
95%
Packaging
250mg
Price
$457
Updated
2021/12/16
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tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Chemical Properties,Usage,Production

Uses

tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate is a reagent used for the preparation of γ-butyrolactone derivative via Baeyer-Villiger monooxygenase (BVMO)-catalyzed oxidation.

Synthesis

A solution of crude tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate (1.00 g,4.69mmol, 1.00 equiv) in dichloromethane(20 mL) was treated with Dess-Martin periodinane(2.10g,4.95 mmol, 1.06 equiv) in two batches a few min apart at 0 °C. After 10 min, the ice bath wasremoved, and the reaction was monitored by TLC (50% ethyl acetate, PMA stain). After 30 min.the reaction was diluted with ethyl acetate and washed twice with satd sodium bicarbonate. Theorganic layer was dried over sodium sulfate, filtered, and concentrated. The crude product waspurified by flash chromatography (80g silica gel, 10 to 50% ethyl acetate/heptane; pure fractionswere identified by TLC with PMA stain; an unidentified impurity elutes slightly earlier than theproduct) to give tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate as a white solid (721 mg,73%). mp 114.5-116C. 

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Suppliers

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View Lastest Price from tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate manufacturers

PNP Biotech Co. Ltd
Product
Tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 1181816-12-5
Price
US $0.00/KG
Min. Order
25KG
Purity
95%
Supply Ability
Inquiry
Release date
2022-09-20
Hebei Duling International Trade Co. LTD
Product
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 1181816-12-5
Price
US $60.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 tons
Release date
2022-10-09
Shaanxi Dideu Medichem Co. Ltd
Product
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 1181816-12-5
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-27

1181816-12-5, tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylateRelated Search:

tert-butyl 6-oxo-2-azaspiro[4.4]nonane-2-carboxylate(WX101410) tertbutyl 5oxo2azaspiro[3.4]octane2carboxylate tert-Butyl 6-hydroxy-2-aza-bicyclo[2.2.1]heptane-2-carboxylate 6-bromo-pyridine-2-carboxylic acid tert-butyl ester cis-1-Boc-3-amino-4-fluor... 1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2R)-(9CI) 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE tert-butyl (cis-3-aminocy... 1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2S)-(9CI) (2-Aza-spiro[3.3]hept-6-yl)-carbamic acid tert-butyl ester 1-Azetidinecarboxylic aci... 1-BOC-3-METHYLAMINOAZETIDINE 2-(tert-Butoxycarbonyl)-2,7-diazaspiro[3.5]nonane tert-butyl (cis-3-aminocy... 3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, 1,1-diMethylethyl ester tert-butyl 6-oxo-1,4-oxazepane-4-carboxylate 4-Boc-6-amino-1,4-oxazepane 6,9-DIAZA-SPIRO[4.5]DECANE-6-CARBOXYLIC ACID TERT-BUTYL ESTER

  • 6-Oxo-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester
  • 6-oxo-2-azaspiro[3.3]hept...
  • 2-Boc-6-oxo-2-azaspiro[3....
  • 2-Boc-6-oxo-2-azaspiro[3.3]heptane
  • tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-carboxylate
  • 2-Azaspiro[3.4]octane-2-carboxylic acid, 6-oxo-, 1,1-dimethylethyl ester
  • 6-Oxo-2-azaspiro[3.3]heptane-2-carboxylic acid dimethylethyl ester
  • tert-Butyl 7-oxo-2-azaspiro[3.4]octane-2-carboxylate
  • tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
  • tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-ca
  • 6-oxo-2-azaspiro[3.3]heptane-2-carboxyL
  • ert-Butyl6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
  • Tert-butyl-6-oxo-2-azaspiro[3,3]heptane-2-carxylate
  • 1181816-12-5
  • 1363382-39-1 oldold
  • MFCD22421762 oldold