1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE

Product Name: 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE
CAS No.: 614730-97-1
Chemical Name: 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE
Synonyms: tert-butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate;1-Boc-4-fluoro-4-(hydroxy...;1-BOC-4-FLUORO-4 (HYDROXYMETHYL);1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE;tert-Butyl 4-fluoro-4-(hydroxymethyl)-1-piperidinecarboxylate;tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate 97%;1,1-Dimethylethyl 4-fluoro-4-(hydroxymethyl)-1-piperidinecarboxylate;4-fluoro-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester;1-PIPERIDINECARBOXYLIC ACID, 4-FLUORO-4-(HYDROXYMETHYL)-, 1,1-DIMETHYLETHYL ESTER
CBNumber: CB5347225
Molecular Formula: C11H20FNO3
Formula Weight: 233.28
MOL File: 614730-97-1.mol

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1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE Property

Boiling point:: 311.0±27.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.94±0.10(Predicted)
Appearance: Colorless to off-white Solid-Liquid Mixture
InChI: InChI=1S/C11H20FNO3/c1-10(2,3)16-9(15)13-6-4-11(12,8-14)5-7-13/h14H,4-8H2,1-3H3
InChIKey: BWZOULIMVKCGII-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(F)(CO)CC1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B809640
Product name: tert-Butyl4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate
Packaging: 500mg
Price: $130
Updated: 2021/12/16

Matrix Scientific

Product number: 096940
Product name: 1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine
Purity: 95+%
Packaging: 250mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-W000442
Product name: 1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine
Packaging: 1g
Price: $82
Updated: 2021/12/16

Matrix Scientific

Product number: 096940
Product name: 1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine
Purity: 95+%
Packaging: 500mg
Price: $116
Updated: 2021/12/16

Apolloscientific

Product number: PC430313
Product name: tert-Butyl4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate
Purity: 97%
Packaging: 250mg
Price: $76
Updated: 2021/12/16

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1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE Chemical Properties,Usage,Production

Uses

tert-Butyl 4-Fluoro-4-(hydroxymethyl)piperidine-1-carboxylate is used in preparation of heterocyclic compounds as BCL 2 inhibitors.

Synthesis

147804-30-6

614730-97-1

General procedure for the synthesis of 1-Boc-4-fluoro-4-(hydroxymethyl)piperidine from 1-oxa-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester: Commercially available epoxide (2 g, 9.38 mmol) was dissolved in 10 mL of dichloromethane, and added slowly and dropwise to a pre-cooled to -10°C 0.6 mL solution of HF pyridinium fluoride (70%) in a 10 mL dichloromethane to a mixture of 0.6 mL HF pyridinium fluoride (70%) and 10 mL methylene chloride. The reaction mixture was kept at -10°C. After the dropwise addition was completed, the reaction system was warmed to room temperature and stirred continuously for 4 hours. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and subsequently washed with saturated aqueous sodium carbonate solution. The organic phase was separated, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to remove the solvent to give the crude product. Purification by silica gel column chromatography with ethyl acetate/heptane (20% to 50%) as eluent afforded 1-Boc-4-fluoro-4-(hydroxymethyl)piperidine as a pale yellow oil (1.44 g, 66% yield).1H-NMR (400 MHz, CDCl3) data: δ=1.44 (s, 9H), 1.47-1.63 (m, 2H). 1.85 (m, 2H), 3.08 (m, 2H), 3.56 (s, 1H), 3.61 (s, 1H), 3.92 (brs, 2H). ms ESI: m/z=233.98 (M+).

References

[1] Patent: US2011/256064, 2011, A1. Location in patent: Page/Page column 19; 20
[2] Patent: EP2377860, 2011, A1. Location in patent: Page/Page column 26
[3] Patent: EP1505067, 2005, A1. Location in patent: Page/Page column 368; 369
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 13, p. 3692 - 3695
[5] Patent: WO2004/5255, 2004, A1. Location in patent: Page 26-27

1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE Suppliers

China 93 Germany 1 India 1 United Kingdom 2 United States 12 Global 109

Shanghai AQBioPharma Co., Ltd.

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View Lastest Price from 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE manufacturers

Career Henan Chemical Co

Product: 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE 614730-97-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-08-26

614730-97-1, 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINERelated Search:

4-Cyano-4-(toluene-4-sulfonyloxyMethyl)-piperidine-1-carboxylic acid tert-butyl ester cis-1-Boc-3-amino-4-fluor... 1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2R)-(9CI) tert-butyl (cis-3-aminocy... 1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2S)-(9CI) (2-Aza-spiro[3.3]hept-6-yl)-carbamic acid tert-butyl ester 1-Azetidinecarboxylic aci... 1-BOC-3-METHYLAMINOAZETIDINE 2-(tert-Butoxycarbonyl)-2,7-diazaspiro[3.5]nonane tert-butyl (cis-3-aminocy... tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 4-FLUORO-1-(1,1-DIMETHYLETHYL)1,4-PIPERIDINEDICARBOXYLIC ACID-4-ETHYL ESTER 1-BOC-4-FLUORO-4-PIPERIDINECARBOXYLIC ACID 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE 4-FLUORO-1,4-PIPERIDINEDICHARBOXYLIC ACID,1(1,1-DIMETHYLETHYL)ESTER, LITHIUM SALT 4-FLUOROPIPERIDINE 4-FLUORO-4-HYDROXYMETHYL-1-METHYLPIPERIDINE

1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE

1-PIPERIDINECARBOXYLIC ACID, 4-FLUORO-4-(HYDROXYMETHYL)-, 1,1-DIMETHYLETHYL ESTER

tert-butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate

1-Boc-4-fluoro-4-(hydroxy...

4-fluoro-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester

tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate 97%

1,1-Dimethylethyl 4-fluoro-4-(hydroxymethyl)-1-piperidinecarboxylate

1-BOC-4-FLUORO-4 (HYDROXYMETHYL)

tert-Butyl 4-fluoro-4-(hydroxymethyl)-1-piperidinecarboxylate

614730-97-1

C11H20FNO3