ChemicalBook > CAS DataBase List > 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE

1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE

Product Name
1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE
CAS No.
614730-97-1
Chemical Name
1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE
Synonyms
tert-butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate;1-Boc-4-fluoro-4-(hydroxy...;1-BOC-4-FLUORO-4 (HYDROXYMETHYL);1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE;tert-Butyl 4-fluoro-4-(hydroxymethyl)-1-piperidinecarboxylate;tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate 97%;1,1-Dimethylethyl 4-fluoro-4-(hydroxymethyl)-1-piperidinecarboxylate;4-fluoro-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester;1-PIPERIDINECARBOXYLIC ACID, 4-FLUORO-4-(HYDROXYMETHYL)-, 1,1-DIMETHYLETHYL ESTER
CBNumber
CB5347225
Molecular Formula
C11H20FNO3
Formula Weight
233.28
MOL File
614730-97-1.mol
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1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE Property

Boiling point:
311.0±27.0 °C(Predicted)
Density 
1.13±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
14.94±0.10(Predicted)
Appearance
Colorless to off-white Solid-Liquid Mixture
InChI
InChI=1S/C11H20FNO3/c1-10(2,3)16-9(15)13-6-4-11(12,8-14)5-7-13/h14H,4-8H2,1-3H3
InChIKey
BWZOULIMVKCGII-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(F)(CO)CC1
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B809640
Product name
tert-Butyl4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate
Packaging
500mg
Price
$130
Updated
2021/12/16
Matrix Scientific
Product number
096940
Product name
1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine
Purity
95+%
Packaging
250mg
Price
$80
Updated
2021/12/16
ChemScene
Product number
CS-W000442
Product name
1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine
Packaging
1g
Price
$82
Updated
2021/12/16
Matrix Scientific
Product number
096940
Product name
1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine
Purity
95+%
Packaging
500mg
Price
$116
Updated
2021/12/16
Apolloscientific
Product number
PC430313
Product name
tert-Butyl4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate
Purity
97%
Packaging
250mg
Price
$76
Updated
2021/12/16
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1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE Chemical Properties,Usage,Production

Uses

tert-Butyl 4-Fluoro-4-(hydroxymethyl)piperidine-1-carboxylate is used in preparation of heterocyclic compounds as BCL 2 inhibitors.

Synthesis

147804-30-6

614730-97-1

General procedure for the synthesis of 1-Boc-4-fluoro-4-(hydroxymethyl)piperidine from 1-oxa-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester: Commercially available epoxide (2 g, 9.38 mmol) was dissolved in 10 mL of dichloromethane, and added slowly and dropwise to a pre-cooled to -10°C 0.6 mL solution of HF pyridinium fluoride (70%) in a 10 mL dichloromethane to a mixture of 0.6 mL HF pyridinium fluoride (70%) and 10 mL methylene chloride. The reaction mixture was kept at -10°C. After the dropwise addition was completed, the reaction system was warmed to room temperature and stirred continuously for 4 hours. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and subsequently washed with saturated aqueous sodium carbonate solution. The organic phase was separated, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to remove the solvent to give the crude product. Purification by silica gel column chromatography with ethyl acetate/heptane (20% to 50%) as eluent afforded 1-Boc-4-fluoro-4-(hydroxymethyl)piperidine as a pale yellow oil (1.44 g, 66% yield).1H-NMR (400 MHz, CDCl3) data: δ=1.44 (s, 9H), 1.47-1.63 (m, 2H). 1.85 (m, 2H), 3.08 (m, 2H), 3.56 (s, 1H), 3.61 (s, 1H), 3.92 (brs, 2H). ms ESI: m/z=233.98 (M+).

References

[1] Patent: US2011/256064, 2011, A1. Location in patent: Page/Page column 19; 20
[2] Patent: EP2377860, 2011, A1. Location in patent: Page/Page column 26
[3] Patent: EP1505067, 2005, A1. Location in patent: Page/Page column 368; 369
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 13, p. 3692 - 3695
[5] Patent: WO2004/5255, 2004, A1. Location in patent: Page 26-27

1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE Suppliers

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View Lastest Price from 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE manufacturers

Career Henan Chemical Co
Product
1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE 614730-97-1
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-08-26

614730-97-1, 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINERelated Search:

4-Cyano-4-(toluene-4-sulfonyloxyMethyl)-piperidine-1-carboxylic acid tert-butyl ester cis-1-Boc-3-amino-4-fluor... 1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2R)-(9CI) tert-butyl (cis-3-aminocy... 1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2S)-(9CI) (2-Aza-spiro[3.3]hept-6-yl)-carbamic acid tert-butyl ester 1-Azetidinecarboxylic aci... 1-BOC-3-METHYLAMINOAZETIDINE 2-(tert-Butoxycarbonyl)-2,7-diazaspiro[3.5]nonane tert-butyl (cis-3-aminocy... tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 4-FLUORO-1-(1,1-DIMETHYLETHYL)1,4-PIPERIDINEDICARBOXYLIC ACID-4-ETHYL ESTER 1-BOC-4-FLUORO-4-PIPERIDINECARBOXYLIC ACID 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE 4-FLUORO-1,4-PIPERIDINEDICHARBOXYLIC ACID,1(1,1-DIMETHYLETHYL)ESTER, LITHIUM SALT 4-FLUOROPIPERIDINE 4-FLUORO-4-HYDROXYMETHYL-1-METHYLPIPERIDINE

  • 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE
  • 1-PIPERIDINECARBOXYLIC ACID, 4-FLUORO-4-(HYDROXYMETHYL)-, 1,1-DIMETHYLETHYL ESTER
  • tert-butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate
  • 1-Boc-4-fluoro-4-(hydroxy...
  • 4-fluoro-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester
  • tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate 97%
  • 1,1-Dimethylethyl 4-fluoro-4-(hydroxymethyl)-1-piperidinecarboxylate
  • 1-BOC-4-FLUORO-4 (HYDROXYMETHYL)
  • tert-Butyl 4-fluoro-4-(hydroxymethyl)-1-piperidinecarboxylate
  • 614730-97-1
  • C11H20FNO3