CYC-116
- Product Name
- CYC-116
- CAS No.
- 693228-63-6
- Chemical Name
- CYC-116
- Synonyms
- CS-405;CYC161;CYC-116;CYC 116; CYC-116;CYC-116 USP/EP/BP;4-(2-amino-4-methylthiazol-5-yl)-N-(4-morpholinophenyl)pyrimidin-2-amine;4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine;4-(2-Amino-4-methyl-5-thiazolyl)-N-[4-(4-morpholinyl)phenyl]- 2-Pyrimidinamine;2-Pyrimidinamine, 4-(2-amino-4-methyl-5-thiazolyl)-N-[4-(4-morpholinyl)phenyl]-;CYC-1164-(2-amino-4-methylthiazol-5-yl)-N-(4-morpholinophenyl)pyrimidin-2-amine
- CBNumber
- CB02473684
- Molecular Formula
- C18H20N6OS
- Formula Weight
- 368.46
- MOL File
- 693228-63-6.mol
CYC-116 Property
- Melting point:
- 270-277°C (dec.)
- Boiling point:
- 648.8±65.0 °C(Predicted)
- Density
- 1.355
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- solubility
- Aqueous Acid, DMSO (Sparingly)
- form
- Brown powder.
- pka
- 5.96±0.40(Predicted)
- color
- Pale Yellow
- CAS DataBase Reference
- 693228-63-6
N-Bromosuccinimide Price
- Product number
- 21205
- Product name
- CYC-116
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21205
- Product name
- CYC-116
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 21205
- Product name
- CYC-116
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 21205
- Product name
- CYC-116
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $190
- Updated
- 2024/03/01
- Product number
- 007247
- Product name
- CYC-116
- Packaging
- 5mg
- Price
- $496
- Updated
- 2021/12/16
CYC-116 Chemical Properties,Usage,Production
Uses
CYC116 is a potent inhibitor of Aurora A/B and VEGFR with Ki of 8.0 nM/9.2 nM and 44 nM, respectively.
Biological Activity
ki: 8.0 and 9.2 nm for aurora a and b, respectivelythe aurora kinases are a family of serine-threonine kinases that interact with components of the mitotic apparatus and that regulate aspects of centrosome maturation, bipolar spindle assembly, chromosome segregation, and cytokinesis. cyc116 has been discoverd as a novel n-phenyl-4-(thiazol-5-yl) pyrimidin-2-amine aurora kinase inhibitor.
in vitro
the anticancer effects of cyc116 were shown to emanate from cell death following mitotic failure and increased polyploidy as a consequence of cellular inhibition of aurora a and b kinases. moreover, cyc116 was also assessed against other kinases [1].
in vivo
preliminary in vivo assessment showed that cyc116 was orally bioavailable and possessed anticancer activity. the mean relative tumor volumes of mice receiving cyc116 at both dose levels were less than those of vehicle-treated mice for the duration of the study period [1].
target
Aurora A
IC 50
44 and 19 nm respectively for aurora a and b in cancer cells
References
[1] wang s, midgley ca, scaërou f, grabarek jb, griffiths g, jackson w, kontopidis g, mcclue sj, mcinnes c, meades c, mezna m, plater a, stuart i, thomas mp, wood g, clarke rg, blake dg, zheleva di, lane dp, jackson rc, glover dm, fischer pm. discovery of n-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors. j med chem. 2010;53(11):4367-78.
CYC-116 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CYC-116 manufacturers
- Product
- CYC-116 693228-63-6
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23