Doramapimod
- Product Name
- Doramapimod
- CAS No.
- 285983-48-4
- Chemical Name
- Doramapimod
- Synonyms
- BIRB 796 (DoraMapiMod);CS-379;CS-1863;BIBR-796;BIRB 796;BIRB 796BS;doramapimod;BIRB-796;BIRB796;DoraMapin BIBR796;BIBR-796(DoraMapiMod)
- CBNumber
- CB2855127
- Molecular Formula
- C31H37N5O3
- Formula Weight
- 527.66
- MOL File
- 285983-48-4.mol
Doramapimod Property
- Melting point:
- 142-143 °C
- Boiling point:
- 631.6±55.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml).
- form
- solid
- pka
- 13.47±0.70(Predicted)
- color
- White or off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 506172
- Product name
- p38 MAP Kinase Inhibitor X, BIRB 796 - CAS 285983-48-4 - Calbiochem
- Packaging
- 10mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 10460
- Product name
- Doramapimod
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $26
- Updated
- 2024/03/01
- Product number
- 10460
- Product name
- Doramapimod
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 10460
- Product name
- Doramapimod
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $87
- Updated
- 2024/03/01
- Product number
- 10460
- Product name
- Doramapimod
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $153
- Updated
- 2024/03/01
Doramapimod Chemical Properties,Usage,Production
Description
Doramapimod (285983-48-4) potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1?(IC50=18 nM). Displays anti-inflammatory activity2?but differential effects on inflammatory genes3. Cell permeable.
Chemical Properties
Pale Beige Solid
Uses
Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bo rtezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation.
Uses
Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation.
Definition
ChEBI: A member of the class of pyrazoles that is an immunomodulator used for treatment of rheumatoid arthritis, Crohn's disease and psoriasis.
in vitro
birb 796 is a picomolar inhibitor of human p38 map kinase with a 12,000-fold increase in binding affinity. moreover, birb 796 behavors as one of the most potent and slowest dissociating human p38 map kinase inhibitors now known [1].
in vivo
in a lps-stimulated tnf-α synthesis mouse model, a 65% inhibition of tnf-α synthesis was observed when birb 796 was dosed orally at 10 mg/kg. in a model of established collagen-induced arthritis using b10.riii mice, birb 796 showed a 63% inhibition of arthritis severity when dosed orally at 30 mg/kg qd [2].
storage
Store at -20°C
References
1) Pargellis?et al. (2002),?Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site; Nat. Struct. Biol.,?9?268 2) Branger?et al.?(2002),?Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia; J. Immunol.,?168?4070 3) Joos?et al. (2010),?Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1 beta-stimulated human chondrocytes; Br. J. Pharmacol.,?160?1252
Doramapimod Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Doramapimod manufacturers
- Product
- Doramapimod 285983-48-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Doramapimod 285983-48-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- Doramapimod 285983-48-4
- Price
- US $3.00/KG
- Min. Order
- 3KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-08-26