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Doramapimod

Product Name
Doramapimod
CAS No.
285983-48-4
Chemical Name
Doramapimod
Synonyms
BIRB 796 (DoraMapiMod);CS-379;CS-1863;BIBR-796;BIRB 796;BIRB 796BS;doramapimod;BIRB-796;BIRB796;DoraMapin BIBR796;BIBR-796(DoraMapiMod)
CBNumber
CB2855127
Molecular Formula
C31H37N5O3
Formula Weight
527.66
MOL File
285983-48-4.mol
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Doramapimod Property

Melting point:
142-143 °C
Boiling point:
631.6±55.0 °C(Predicted)
Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml).
form 
solid
pka
13.47±0.70(Predicted)
color 
White or off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
506172
Product name
p38 MAP Kinase Inhibitor X, BIRB 796 - CAS 285983-48-4 - Calbiochem
Packaging
10mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
10460
Product name
Doramapimod
Purity
≥98%
Packaging
1mg
Price
$26
Updated
2024/03/01
Cayman Chemical
Product number
10460
Product name
Doramapimod
Purity
≥98%
Packaging
5mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
10460
Product name
Doramapimod
Purity
≥98%
Packaging
10mg
Price
$87
Updated
2024/03/01
Cayman Chemical
Product number
10460
Product name
Doramapimod
Purity
≥98%
Packaging
25mg
Price
$153
Updated
2024/03/01
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Doramapimod Chemical Properties,Usage,Production

Description

Doramapimod (285983-48-4) potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1?(IC50=18 nM). Displays anti-inflammatory activity2?but differential effects on inflammatory genes3. Cell permeable.

Chemical Properties

Pale Beige Solid

Uses

Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation.

Definition

ChEBI: A member of the class of pyrazoles that is an immunomodulator used for treatment of rheumatoid arthritis, Crohn's disease and psoriasis.

in vitro

birb 796 is a picomolar inhibitor of human p38 map kinase with a 12,000-fold increase in binding affinity. moreover, birb 796 behavors as one of the most potent and slowest dissociating human p38 map kinase inhibitors now known [1].

in vivo

in a lps-stimulated tnf-α synthesis mouse model, a 65% inhibition of tnf-α synthesis was observed when birb 796 was dosed orally at 10 mg/kg. in a model of established collagen-induced arthritis using b10.riii mice, birb 796 showed a 63% inhibition of arthritis severity when dosed orally at 30 mg/kg qd [2].

storage

Store at -20°C

References

1) Pargellis?et al. (2002),?Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site; Nat. Struct. Biol.,?9?268 2) Branger?et al.?(2002),?Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia; J. Immunol.,?168?4070 3) Joos?et al. (2010),?Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1 beta-stimulated human chondrocytes; Br. J. Pharmacol.,?160?1252

Doramapimod Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Doramapimod manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Doramapimod 285983-48-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Doramapimod 285983-48-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
Doramapimod 285983-48-4
Price
US $3.00/KG
Min. Order
3KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-08-26

285983-48-4, DoramapimodRelated Search:

Cyhalofop-butyl Diethylene glycol monobutyl ether Moroxydine hydrochloride Butylnaphtalenesulfonic Acid Sodium Salt tert-Butanol tert-Butylchlorodiphenylsilane Buprofezin 2-Butoxyethanol Tridemorph Moroxydine Butyl acetate Butyl acrylate Dimethomorph MORPHINE 5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine 4-(2-MORPHOLIN-4-YLETHOXY)ANILINE 4-(2-Morpholinoethoxy)naphthalen-1-amine BIRB 796 (Doramapimod)

  • 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea
  • 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
  • BIRB 796; BIRB-796; BIRB796;
  • CS-379
  • BIRB 796 - BIRB 0796 | Doramapimod
  • CS-1863
  • BIBR-796
  • 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea
  • DoraMapiMod, BIBR-796
  • BIBR-796(DoraMapiMod)
  • BIRB 796 (DoraMapiMod)
  • BIRB 796BS
  • N-[3-(1,1-DiMethylethyl)-1-(4-Methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-Morpholinyl)ethoxy]-1-naphthalenyl]urea
  • DoraMapin BIBR796
  • DoraMapiMod (BIRB-796)
  • BIRB 796
  • doramapimod
  • Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-
  • 1-[2-(4-Methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea BIRB 796 (Doramapimod)
  • Doramapimod 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea
  • DORAMAPIMOD;BIRB 796;BIRB796
  • 3-[3-Tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea
  • 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
  • 1-(3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1h-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea
  • BIRB-796;BIRB796
  • Doramapimod USP/EP/BP
  • p38 MAP Kinase Inhibitor X BIRB-796 Doramapimod
  • 1-[3-(tert-Butyl)-1-(p-tolyl)-5-pyrazolyl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea
  • Doramapimod, p38 MAPK inhibitor
  • Doramapimod, 10 mM in DMSO
  • 285983-48-4
  • C31H37N5O3
  • Anti-cancer&immunity
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Protein Kinase Inhibitors and Activators
  • MAPK
  • Inhibitors