5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine
- Product Name
- 5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine
- CAS No.
- 285984-25-0
- Chemical Name
- 5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine
- Synonyms
- STK234818;ZINC02527276;BUTTPARK 74\09-04;5-AMINO-3-T-BUTYL-1-P-TOLYL-PYRAZOLE;5-t-butyl-2-p-tolyl-2H-pyrazol-3-ylamine;5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YLAMINE;3-tert-Butyl-1-p-tolyl-1H-pyrazol-5-ylamine;3-TERT-BUTYL-1-(P-TOLYL)-1H-PYRAZOLE-5-AMINE;5-tert-butyl-2-(4-Methylphenyl)pyrazol-3-aMine;5-tert-butyl-2-(4-methylphenyl)-3-pyrazolamine
- CBNumber
- CB2206125
- Molecular Formula
- C14H19N3
- Formula Weight
- 229.32
- MOL File
- 285984-25-0.mol
5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine Property
- Boiling point:
- 368.3±37.0 °C(Predicted)
- Density
- 1.06±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- solid
- pka
- 4.17±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C14H19N3/c1-10-5-7-11(8-6-10)17-13(15)9-12(16-17)14(2,3)4/h5-9H,15H2,1-4H3
- InChIKey
- ITHNHEWXIBNEDG-UHFFFAOYSA-N
- SMILES
- N1(C2=CC=C(C)C=C2)C(N)=CC(C(C)(C)C)=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- JRD0050
- Product name
- 5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $259
- Updated
- 2025/07/31
- Product number
- B810518
- Product name
- 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB51086
- Product name
- 5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine
- Packaging
- 100mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- V0035
- Product name
- 5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine
- Packaging
- 1g
- Price
- $81
- Updated
- 2021/12/16
- Product number
- FB51086
- Product name
- 5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine
- Packaging
- 500mg
- Price
- $170
- Updated
- 2021/12/16
5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine Chemical Properties,Usage,Production
Synthesis
59997-51-2
637-60-5
285984-25-0
General procedure for the synthesis of 5-tert-butyl-2-p-tolyl-2H-pyrazol-3-amine from 4,4-dimethyl-3-oxopentanenitrile and 4-methylphenylhydrazine hydrochloride: 4-methylphenylhydrazine hydrochloride (5.20 g, 33 mmol) and 4,4-dimethyl-3-oxopentanenitrile (3.75 g, 30 mmol) were dissolved in an ethanol solution of 0.4 M HCl (100 mL) and heated at reflux for 48 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted to 10-11 by slow addition of 1 M NaOH solution.Subsequently, the reaction mixture was partitioned between water and ethyl acetate. The aqueous phase was extracted twice with dichloromethane. All organic phases were combined, washed sequentially with water and saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was recrystallized from a solvent mixture of ethyl acetate and petroleum ether to give 5-tert-butyl-2-p-tolyl-2H-pyrazol-3-amine (compound 25a) as a white solid (5.88 g, 86% yield).
References
[1] Patent: US2004/192653, 2004, A1
[2] Molecules, 2014, vol. 19, # 2, p. 2004 - 2028
[3] Molecules, 2015, vol. 20, # 9, p. 16604 - 16619
[4] Organic Process Research and Development, 2010, vol. 14, # 3, p. 650 - 656
[5] Journal of the American Chemical Society, 2009, vol. 131, # 37, p. 13286 - 13296
5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine manufacturers
- Product
- 5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine 285984-25-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-25