ChemicalBook > CAS DataBase List > PHA-680632

PHA-680632

Product Name
PHA-680632
CAS No.
398493-79-3
Chemical Name
PHA-680632
Synonyms
CS-411;PHA-680632 USP/EP/BP;PHA-680632(PHA680632);PHA-680632;PHA680632;PHA 680632;Aurora Kinase,PHA-680632,Inhibitor,inhibit;Pyrrolo[3,4-c]pyrazole-5(1H)-carboxaMide, N-(2,6-diethylphenyl)-;N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)-benzoyl]amino]pyrrolo[3,4-c]p;N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)-benzoyl]amino]pyrrolo[3,4-c]pyra;N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)pyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxamide;N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
CBNumber
CB02484639
Molecular Formula
C28H35N7O2
Formula Weight
501.62
MOL File
398493-79-3.mol
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PHA-680632 Property

Melting point:
240-242 °C
Boiling point:
709.0±60.0 °C(Predicted)
Density 
1.294
storage temp. 
Store at -20°C
solubility 
≥50.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form 
Powder
pka
12.26±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28381
Product name
PHA-680632
Packaging
25mg
Price
$724
Updated
2024/03/01
Cayman Chemical
Product number
28381
Product name
PHA-680632
Packaging
50mg
Price
$1085
Updated
2024/03/01
Cayman Chemical
Product number
28381
Product name
PHA-680632
Packaging
5mg
Price
$183
Updated
2024/03/01
Cayman Chemical
Product number
28381
Product name
PHA-680632
Packaging
10mg
Price
$328
Updated
2024/03/01
ChemScene
Product number
CS-0194
Product name
PHA-680632
Purity
98.48%
Packaging
10mg
Price
$228
Updated
2021/12/16
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PHA-680632 Chemical Properties,Usage,Production

Uses

PHA-680632 is a potent and selective inhibitor of Aurora kinase.

Biological Activity

pha-680632 is a novel and potent inhibitor of aurora kinases, a small family of serine/threonine kinases regulating mitosis in chromosome segregation and cell division, that inhibits the activity of all three aurora kinases with 50% inhibition concentration ic50 values of 27 nm, 135 nm and 120 nm for aurora a, b and c kinases respectively. pha-680632 also cross-reacts with other kinases, including fgfr1, flt3, lck, plk1, stlk2, vegfr2 and vegfr3, to a lesser extent and exhibits much higher ic50 values (390 to 5500 nm) compared to aurora kinases. moreover, pha-680632 potently inhibits proliferation in a wide range of cancer cell types, including hct116, a2780, hl60 and hela cells, with ic50 values ranging from 0.06 to 7.15 μm.soncini c, carpinelli p, gianellini l, fancelli d, vianello p, rusconi l, storici p, zugnoni p, pesenti e, croci v, ceruti r, giorgini ml, cappella p, ballinari d, sola f, varasi m, bravo r, moll j. pha-680632, a novel aurora kinase inhibitor with potent antitumoral activity. clin cancer res. 2006 jul 1;12(13):4080-9.

target

Aurora A

PHA-680632 Preparation Products And Raw materials

Raw materials

Preparation Products

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PHA-680632 Suppliers

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398493-79-3, PHA-680632Related Search:

NU7441 (KU-57788) AZD-8055 (+)-JQ1 MG-132 PD 0332991 HCl Doxorubicin hydrochloride

  • N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
  • Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(2,6-diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]-
  • Pyrrolo[3,4-c]pyrazole-5(1H)-carboxaMide, N-(2,6-diethylphenyl)-
  • N-(2,6-diethylphenyl)-3-(4-(4-Methylpiperazin-1-yl)benzaMido)-3a,4,6,6a-tetrahydropyrrolo[3,4-c]pyrazole-5(3H)-carboxaMide
  • PHA-680632(PHA680632)
  • N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)-benzoyl]amino]pyrrolo[3,4-c]pyra
  • N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)pyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxamide
  • PHA-680632;PHA680632;PHA 680632
  • N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)-benzoyl]amino]pyrrolo[3,4-c]p
  • N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
  • CS-411
  • N-(2,6-diethylphenyl)-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamide
  • PHA-680632 USP/EP/BP
  • Aurora Kinase,PHA-680632,Inhibitor,inhibit
  • 398493-79-3
  • Inhibitors
  • Inhibitor