ChemicalBook > CAS DataBase List > PHA-680632

PHA-680632

Product Name: PHA-680632
CAS No.: 398493-79-3
Chemical Name: PHA-680632
Synonyms: CS-411;PHA-680632 ，S1454;PHA-680632 USP/EP/BP;PHA-680632(PHA680632);PHA-680632, 10 mM in DMSO;PHA-680632;PHA680632;PHA 680632;Aurora Kinase,PHA-680632,Inhibitor,inhibit;Pyrrolo[3,4-c]pyrazole-5(1H)-carboxaMide, N-(2,6-diethylphenyl)-;N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)-benzoyl]amino]pyrrolo[3,4-c]p;N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)-benzoyl]amino]pyrrolo[3,4-c]pyra
CBNumber: CB02484639
Molecular Formula: C28H35N7O2
Formula Weight: 501.62
MOL File: 398493-79-3.mol

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PHA-680632 Property

Melting point:: 240-242 °C
Boiling point:: 709.0±60.0 °C(Predicted)
Density: 1.294
storage temp.: Store at -20°C
solubility: ≥50.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form: Powder
pka: 12.26±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3721
Product name: PHA-680632
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $151.05
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3721
Product name: PHA-680632
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $639
Updated: 2025/07/31

Cayman Chemical

Product number: 28381
Product name: PHA-680632
Packaging: 25mg
Price: $724
Updated: 2024/03/01

Cayman Chemical

Product number: 28381
Product name: PHA-680632
Packaging: 50mg
Price: $1085
Updated: 2024/03/01

Cayman Chemical

Product number: 28381
Product name: PHA-680632
Packaging: 5mg
Price: $183
Updated: 2024/03/01

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PHA-680632 Chemical Properties,Usage,Production

Uses

PHA-680632 is a potent and selective inhibitor of Aurora kinase.

Biological Activity

pha-680632 is a novel and potent inhibitor of aurora kinases, a small family of serine/threonine kinases regulating mitosis in chromosome segregation and cell division, that inhibits the activity of all three aurora kinases with 50% inhibition concentration ic50 values of 27 nm, 135 nm and 120 nm for aurora a, b and c kinases respectively. pha-680632 also cross-reacts with other kinases, including fgfr1, flt3, lck, plk1, stlk2, vegfr2 and vegfr3, to a lesser extent and exhibits much higher ic50 values (390 to 5500 nm) compared to aurora kinases. moreover, pha-680632 potently inhibits proliferation in a wide range of cancer cell types, including hct116, a2780, hl60 and hela cells, with ic50 values ranging from 0.06 to 7.15 μm.soncini c, carpinelli p, gianellini l, fancelli d, vianello p, rusconi l, storici p, zugnoni p, pesenti e, croci v, ceruti r, giorgini ml, cappella p, ballinari d, sola f, varasi m, bravo r, moll j. pha-680632, a novel aurora kinase inhibitor with potent antitumoral activity. clin cancer res. 2006 jul 1;12(13):4080-9.

in vivo

PHA-680632 suppresses tumor growth in animal models. PHA-680632 treatment at 45 mg/kg dose results in 85% of TGI without signs of toxicity in the HL60 human acute myelogenous leukemia xenograft model. PHA-680632 treatment at 60 mg/kg i.v. b.i.d. for 5 days results in 78% of TGI without signs of toxicity in the A2780 human ovarian carcinoma model^[1]. PHA680632 in association with radiation leads to an additive effect in cancer cells, especially in the p53-deficient cells, but does not act as a radiosensitiser^[2].

target

Aurora A

IC 50

Aurora A: 27 nM (IC₅₀); Aurora B: 135 nM (IC₅₀); Aurora C: 120 nM (IC₅₀)

PHA-680632 Preparation Products And Raw materials

Raw materials

Preparation Products

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PHA-680632 Suppliers

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398493-79-3, PHA-680632Related Search:

(+)-JQ-1 NU7441 (KU-57788) AZD-8055 MG-132 PD 0332991 HCl Doxorubicin hydrochloride

N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(2,6-diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]-

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxaMide, N-(2,6-diethylphenyl)-

N-(2,6-diethylphenyl)-3-(4-(4-Methylpiperazin-1-yl)benzaMido)-3a,4,6,6a-tetrahydropyrrolo[3,4-c]pyrazole-5(3H)-carboxaMide

PHA-680632(PHA680632)

N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)-benzoyl]amino]pyrrolo[3,4-c]pyra

N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)pyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxamide

PHA-680632;PHA680632;PHA 680632

N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)-benzoyl]amino]pyrrolo[3,4-c]p

N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide

CS-411

N-(2,6-diethylphenyl)-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamide

PHA-680632 USP/EP/BP

Aurora Kinase,PHA-680632,Inhibitor,inhibit

PHA-680632, 10 mM in DMSO

PHA-680632 ，S1454

398493-79-3

Inhibitors

Inhibitor