PHA-680632

Product Name: PHA-680632
CAS No.: 398493-79-3
Chemical Name: PHA-680632
Synonyms: CS-411;PHA-680632 USP/EP/BP;PHA-680632(PHA680632);PHA-680632;PHA680632;PHA 680632;Aurora Kinase,PHA-680632,Inhibitor,inhibit;Pyrrolo[3,4-c]pyrazole-5(1H)-carboxaMide, N-(2,6-diethylphenyl)-;N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)-benzoyl]amino]pyrrolo[3,4-c]p;N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)-benzoyl]amino]pyrrolo[3,4-c]pyra;N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)pyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxamide;N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
CBNumber: CB02484639
Molecular Formula: C28H35N7O2
Formula Weight: 501.62
MOL File: 398493-79-3.mol

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PHA-680632 Property

Melting point:: 240-242 °C
Boiling point:: 709.0±60.0 °C(Predicted)
Density: 1.294
storage temp.: Store at -20°C
solubility: ≥50.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form: Powder
pka: 12.26±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28381
Product name: PHA-680632
Packaging: 25mg
Price: $724
Updated: 2024/03/01

Cayman Chemical

Product number: 28381
Product name: PHA-680632
Packaging: 50mg
Price: $1085
Updated: 2024/03/01

Cayman Chemical

Product number: 28381
Product name: PHA-680632
Packaging: 5mg
Price: $183
Updated: 2024/03/01

Cayman Chemical

Product number: 28381
Product name: PHA-680632
Packaging: 10mg
Price: $328
Updated: 2024/03/01

ChemScene

Product number: CS-0194
Product name: PHA-680632
Purity: 98.48%
Packaging: 10mg
Price: $228
Updated: 2021/12/16

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PHA-680632 Chemical Properties,Usage,Production

Uses

PHA-680632 is a potent and selective inhibitor of Aurora kinase.

Biological Activity

pha-680632 is a novel and potent inhibitor of aurora kinases, a small family of serine/threonine kinases regulating mitosis in chromosome segregation and cell division, that inhibits the activity of all three aurora kinases with 50% inhibition concentration ic50 values of 27 nm, 135 nm and 120 nm for aurora a, b and c kinases respectively. pha-680632 also cross-reacts with other kinases, including fgfr1, flt3, lck, plk1, stlk2, vegfr2 and vegfr3, to a lesser extent and exhibits much higher ic50 values (390 to 5500 nm) compared to aurora kinases. moreover, pha-680632 potently inhibits proliferation in a wide range of cancer cell types, including hct116, a2780, hl60 and hela cells, with ic50 values ranging from 0.06 to 7.15 μm.soncini c, carpinelli p, gianellini l, fancelli d, vianello p, rusconi l, storici p, zugnoni p, pesenti e, croci v, ceruti r, giorgini ml, cappella p, ballinari d, sola f, varasi m, bravo r, moll j. pha-680632, a novel aurora kinase inhibitor with potent antitumoral activity. clin cancer res. 2006 jul 1;12(13):4080-9.

target

Aurora A

PHA-680632 Preparation Products And Raw materials

Raw materials

Preparation Products

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PHA-680632 Suppliers

China 67 China Hong Kong 1 India 1 United States 18 Global 87

Shanghai Boyle Chemical Co., Ltd.

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Email: sales@boylechem.com
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Chembest Research Laboratories Limited

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Email: sales@BioChemBest.com
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Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
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Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
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Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
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Shanghai civi chemical technology co.,Ltd

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Email: sale@labgogo.com
Country: China
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NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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Zhengzhou HSH Science & Technology Co., Ltd.

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Email: 1282296214@qq.com
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398493-79-3, PHA-680632Related Search:

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N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(2,6-diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]-

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxaMide, N-(2,6-diethylphenyl)-

N-(2,6-diethylphenyl)-3-(4-(4-Methylpiperazin-1-yl)benzaMido)-3a,4,6,6a-tetrahydropyrrolo[3,4-c]pyrazole-5(3H)-carboxaMide

PHA-680632(PHA680632)

N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)-benzoyl]amino]pyrrolo[3,4-c]pyra

N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)pyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxamide

PHA-680632;PHA680632;PHA 680632

N-(2,6-Diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)-benzoyl]amino]pyrrolo[3,4-c]p

N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide

CS-411

N-(2,6-diethylphenyl)-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamide

PHA-680632 USP/EP/BP

Aurora Kinase,PHA-680632,Inhibitor,inhibit

398493-79-3

Inhibitors

Inhibitor