7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride

Product Name: 7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride
CAS No.: 600734-06-3
Chemical Name: 7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride
Synonyms: Bay 65-1942 HCl;KINK-1 hydrochloride;Bay 65-1942 (HCl salt);Bay 65-1942 (hydrochloride);KINK-1 hydrochloride >=98% (HPLC);Bay 651942 hydrochloride,Bay 65 1942 hydrochloride;(S)-7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(piperidin-3-yl)-1H-pyrido[2,3-d][1,3]oxazin-2(4H)-one hydrochloride;7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride;2H-Pyrido[2,3-d][1,3]oxazin-2-one,7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-,Hydrochloride(1:1)
CBNumber: CB02484912
Molecular Formula: C22H25N3O4.ClH
Formula Weight: 431.917
MOL File: 600734-06-3.mol

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7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride Property

storage temp.: -20°C
solubility: DMSO : 50 mg/mL (115.76 mM; Need ultrasonic)
form: powder
color: white to beige
optical activity: [α]/D -19 to -24°, c = 0.2 in DMF

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2098
Product name: KINK-1 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $82.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2098
Product name: KINK-1 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $658
Updated: 2024/03/01

ChemScene

Product number: CS-0623
Product name: Bay65-1942hydrochloride
Purity: 99.22%
Packaging: 10mg
Price: $840
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611402
Product name: Bay 65-1942 hydrochloride
Packaging: 10mg
Price: $853.4
Updated: 2021/12/16

ApexBio Technology

Product number: A3230
Product name: Bay65-1942HClsalt
Packaging: 10mg
Price: $1084
Updated: 2021/12/16

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7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride Chemical Properties,Usage,Production

Biochem/physiol Actions

KINK-1 (Kinase Inhibitor of NF-ΚB-1; Bay 65-1942; CmpdA; Compound A) is an ATP-competitive, IKKβ-selective IΚB kinase (IKK) inhibitor (Ki against ATP = 2 nM/IKKβ and 135 nM/IKKα) that potently inhibits IKKβ-catalyzed GST-IΚBα(1–54) phosphorylation (IC50 = 4 nM, 200 nM ATP) without affecting (IC50 >10μM) IKK3 or 27 other kinases, lipases, phosphatases, caspases, and MMPs. KINK-1 effectively inhibits NF-ΚB activation and cytokines production in various human and murine cultures (IC50 from 18 to 502 nM) and is efficacious against LPS-induced plasma TNF-α production in mice and rats in vivo (EC50 = 9.1 and 6.6 mg/kg p.o., repectively) with good pharmacokinetic profile and oral availability. KINK-1 is also shown to effectively inhibit OVA-induced lung inflammation in a rat model of asthma (ED50 <0.3 mg/kg p.o.) without adverse effects to the animals.

7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride Suppliers

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600734-06-3, 7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride Related Search:

Avobenzone p-Anisidine

Bay 65-1942 (HCl salt)

Bay 65-1942 HCl

Bay 65-1942 (hydrochloride)

(S)-7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(piperidin-3-yl)-1H-pyrido[2,3-d][1,3]oxazin-2(4H)-one hydrochloride

7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride

KINK-1 hydrochloride

KINK-1 hydrochloride >=98% (HPLC)

2H-Pyrido[2,3-d][1,3]oxazin-2-one,7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-,Hydrochloride(1:1)

Bay 651942 hydrochloride,Bay 65 1942 hydrochloride

600734-06-3

C22H25N3O4HCl