AT9283

Product Name: AT9283
CAS No.: 896466-04-9
Chemical Name: AT9283
Synonyms: CS-48;J-504568;AT9283, >=98%;AT-9283; AT 9283;AT9283 AKSci SYN1011 AT-9283;N-cyclopropyl-N'-[3-[5-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]Urea;1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea;Urea, N-cyclopropyl-N'-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-;1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea AT9283
CBNumber: CB02484987
Molecular Formula: C19H23N7O2
Formula Weight: 381.43
MOL File: 896466-04-9.mol

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AT9283 Property

Density: 1.45
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: insoluble in H2O; ≥19.05 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic
form: solid
pka: 10.58±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11496
Product name: AT-9283
Purity: ≥98%
Packaging: 5mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 11496
Product name: AT-9283
Purity: ≥98%
Packaging: 10mg
Price: $160
Updated: 2024/03/01

Cayman Chemical

Product number: 11496
Product name: AT-9283
Purity: ≥98%
Packaging: 25mg
Price: $289
Updated: 2024/03/01

Cayman Chemical

Product number: 11496
Product name: AT-9283
Purity: ≥98%
Packaging: 50mg
Price: $445
Updated: 2024/03/01

TRC

Product number: A790300
Product name: AT-9283
Packaging: 25mg
Price: $445
Updated: 2021/12/16

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AT9283 Chemical Properties,Usage,Production

Uses

AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50s = 3, 3, 1.2, 1.1, and 4 nM, respectively). It also potently (IC50 = <1 μM) inhibits many other kinases, including serine/threonine kinases as well as receptor and non-receptor tyrosine kinases. As Aurora kinases have roles in mitosis, inhibitors of these kinases, including AT-9283, have potential in cancer therapy. Consistent with this, AT-9283 is effective in preventing proliferation of cancer cells both in vitro and in vivo and this effect may be enhanced by combination therapy with other chemotherapeutics.[Cayman Chemical]

Definition

ChEBI: 1-cyclopropyl-3-[3-[5-(4-morpholinylmethyl)-2-benzimidazolylidene]-1,2-dihydropyrazol-4-yl]urea is a member of benzimidazoles.

Biological Activity

at9283, a synthetic small heterocyclic molecule discovered using a fragment-based approach, is a novel inhibitor of aurora kinase, a family of serine/threonine kinases regulating both mitosis and meiosis, that potently inhibits aurora kinases a and b, with 50% inhibition concentration ic50 value of 3 nm, as well as janus kinases (jaks), abelson kinase (bcrabl t315i) and flt-3. at9283 has been found to be therapeutic in leukemic cells, myeloproliferative disorders and multiple solid tumor cell lines. study results have shown that at9283 exhibits anti-proliferative activity and induces polyploidy and apoptosis in aggressive b-cell nhl cell lines associated with inhibition of aurora kinase b.qi w, liu x, cooke ls, persky do, miller tp, squires m, mahadevan d. at9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive b-cell lymphomas. int j cancer. 2012 jun 15;130(12):2997-3005. doi: 10.1002/ijc.26324. epub 2011 nov 19.arkenau ht, plummer r, molife lr, olmos d, yap ta, squires m, lewis s, lock v, yule m, lyons j, calvert h, judson i. a phase i dose escalation study of at9283, a small molecule inhibitor of aurora kinases, in patients with advanced solid malignancies. ann oncol. 2012 may;23(5):1307-13. doi: 10.1093/annonc/mdr451. epub 2011 oct 19.

target

Aurora A

AT9283 Preparation Products And Raw materials

Raw materials

Preparation Products

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AT9283 Suppliers

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View Lastest Price from AT9283 manufacturers

Career Henan Chemical Co

Product: AT9283 896466-04-9
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

896466-04-9, AT9283Related Search:

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1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea AT9283

AT9283, >=98%

N-cyclopropyl-N'-[3-[5-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]Urea

Urea, N-cyclopropyl-N'-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-

1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea

CS-48

AT-9283; AT 9283

J-504568

AT9283 AKSci SYN1011 AT-9283

896466-04-9

Inhibitor

Inhibitors