Foretinib (GSK1363089)

Description

Product Name: Foretinib (GSK1363089)
CAS No.: 849217-64-7
Chemical Name: Foretinib (GSK1363089)
Synonyms: Foretinib;XL880;EXEL-2880;GSK089;GSK 1363089;XL-880,Foretinib;EXEL-2880/XL-880;Foretinib, >=98%;XL880(GSK1363089);Foretinib (XL-880)
CBNumber: CB02490083
Molecular Formula: C34H34F2N4O6
Formula Weight: 632.65
MOL File: 849217-64-7.mol

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Foretinib (GSK1363089) Property

Melting point:: >98°C (dec.)
Boiling point:: 828.5±65.0 °C(Predicted)
Density: 1.372
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO (Slightly), Ethanol (Slightly)
pka: 13.14±0.70(Predicted)
form: Yellow powder.
color: Pale Yellow to Yellow
CAS DataBase Reference: 849217-64-7

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P314Get medical advice/attention if you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16249
Product name: Foretinib
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16249
Product name: Foretinib
Purity: ≥98%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 16249
Product name: Foretinib
Purity: ≥98%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 16249
Product name: Foretinib
Purity: ≥98%
Packaging: 25mg
Price: $230
Updated: 2024/03/01

Tocris

Product number: 6056
Product name: GSK1363089
Purity: ≥98%(HPLC)
Packaging: 10
Price: $177
Updated: 2021/12/16

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Foretinib (GSK1363089) Chemical Properties,Usage,Production

Description

Foretinib (GSK1363089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.

Description

Foretinib is a multikinase inhibitor that targets MET and VEGFR2 and also exhibits an inhibitory effect against KIT, Flt-3, PDGFRb, and Tie-2.

Uses

XL880 (GSK1363089, EXEL-2880) is an ATP-competitive inhibitor of MET and KDR with IC50 of 0.4 nM and 0.9 nM, respectively.

Uses

Foretinib (GSK1363089) is an ATP-competitive inhibitor of hepatocyte growth factor (HGF) and Vascular endothelial growth factor (VEGF) Receptor Tyrosine Kinases.

Definition

ChEBI: N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide is an aromatic ether.

Clinical Use

Foretinib has also shown to be effective against ROS1 mutations especially when acquired with crizotinib resistance. A clinical trial investigating the dosing and safety profile of combining foretinib and erlotinib was designed for advanced pretreated NSCLC patients.

in vitro

In vitro, foretinib blocks activation of MET and VEGFR2-induced signaling pathways. In vivo experiments show a dose-dependent decrease in tumor burden in a lung metastasis experimental model.

target

Met

References

[1] qian f1, engst s, yamaguchi k, yu p, won ka, mock l, lou t, tan j, li c, tam d, lougheed j, yakes fm, bentzien f, xu w, zaks t, wooster r,greshock j, joly ah. inhibition of tumor cell growth, invasion, and metastasis by exel-2880 (xl880, gsk1363089), a novel inhibitor of hgf and vegf receptor tyrosine kinases. cancer res. 2009 oct 15;69(20):8009-16. doi: 10.1158/0008-5472.can-08-4889.

Foretinib (GSK1363089) Preparation Products And Raw materials

Raw materials

Preparation Products

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Foretinib (GSK1363089) Suppliers

China 150 India 2 United Kingdom 3 United States 23 Global 178

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View Lastest Price from Foretinib (GSK1363089) manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Foretinib (GSK1363089) 849217-64-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Career Henan Chemical Co

Product: Foretinib (GSK1363089) 849217-64-7
Price: US $2.00/kg
Min. Order: 1 kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

849217-64-7, Foretinib (GSK1363089)Related Search:

XL-765,SAR245409 XL888 XL-388 Everolimus Bortezomib Cabozantinib Dasatinib Crizotinib Olaparib

Foretinib

GSK 1363089

EXEL-2880

XL880

N-[3-Fluoro-4-[[6-(methyloxy)-7-[[3-(morpholin-4-yl)propyl]oxy]quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

N-[3-Fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

XL-880,Foretinib

XL880(GSK1363089)

FORETINIB GLAXOSMITHKLINE PAPILLARY RENAL CELL CARCINOMA PHASE IIRSCH. TRIANGLE PARK, NC (SEE ALSO HEAD/NECK) (888) 825-5249

foretinib N1-{3-fluoro-4-[(6-(Methyloxy)-7-{[3-(4-Morpholinyl)propyl]oxy}-4-quinolinyl)oxy]phenyl}-N1'-(4-fluorophenyl)-1,1-cyclopropanedicarboxaMide

Foretinib (GSK1363089, XL880)

GSK089

GSK1363089; FORETINIB; EXEL-2880

Foretinib, Free Base

EXEL-2880/XL-880

N-(3-fluoro-4-(6-Methoxy-7-(3-Morpholinopropoxy)quinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxaMide

N1'-[3-fluoro-4-[[6-Methoxy-7-(3-Morpholinopropoxy)-4-quinolyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxaMide

GSK1363089/foretinib

N-(3-Fluoro-4-((6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yl)-oxy)phenyl)-N-(4-fluorophenyl)cyc

Foretinib (GSK1363089)

N-[3-Fluoro-4-[[6-(methyloxy)-7-[[3-(morpholin-4-yl)propyl]oxy]quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1

Foretinib, >=98%

Foretinib (XL-880)

1-N'-[3-FLUORO-4-({6-METHOXY-7-[3-(MORPHOLIN-4-YL)PROPOXY]QUINOLIN-4-YL}OXY)PHENYL]-1-N-(4-FLUOROPHENYL)CYCLOPROPANE-1,1-DICARBOXAMIDE

Foretinib (XL880,EXEL-2880)

N-(3-Fluoro-4-((6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yl)-oxy)phenyl)-N-(4-fluorophenyl)

XL880 (GSK1363089, Foretinib, EXEL-2880)

XL-880;EXEL-2880;XL 880

XL-880;GSK089;EXEL-2880;XL 880;GSK-089; GSK 1363089; GSK-1363089

XL880; XL 880; XL-880; GSK1363089; GSK 1363089; GSK-1363089; GSK089; EXEL2880; FORETINIB.

1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-

Foretinib (GSK1363089) USP/EP/BP

N1'-[3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinol...

849217-64-7

C34H34F2N4O6

Inhibitors