Eculizumab

ChemicalBook > CAS DataBase List > Eculizumab

Product Name: Eculizumab
CAS No.: 219685-50-4
Chemical Name: Eculizumab
Synonyms: H5G1.1;Alexion;Soliris;Eculizumab;ECULIZUMABUM;Unii-A3ulp0F556;H5G1.1Vhc H5G1.1vlc;Eculizumab USP/EP/BP;Eculizumab, stock solution;Eculizumab (anti-Complement C5)
CBNumber: CB02491712
Formula Weight: 0
MOL File: Mol file

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Eculizumab Property

storage temp.: Store at -20°C
form: Liquid
color: Colorless to light yellow
CAS DataBase Reference: 219685-50-4

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Safety

Hazardous Substances Data: 219685-50-4(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0007496
Product name: ECULIZUMAB
Purity: 95.00%
Packaging: 5MG
Price: $498.98
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BE165588
Product name: Eculizumab
Packaging: 1mg
Price: $500
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BE165588
Product name: Eculizumab
Packaging: 2mg
Price: $700
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BE165588
Product name: Eculizumab
Packaging: 5mg
Price: $1000
Updated: 2021/12/16

DC Chemicals

Product number: 013343
Product name: Eculizumab
Packaging: 002
Price: $1200
Updated: 2021/12/16

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Eculizumab Chemical Properties,Usage,Production

Description

Eculizumab, a fully humanized anti-C5 monoclonal antibody, was introduced for treating patients with PNH to reduce hemolysis. It is the first therapy to be approved for this rare and life-threatening form of hemolytic anemia. PNH is a clonal hematopoietic stem-cell disorder that is characterized by the production of abnormal red blood cells (RBCs) with a deficiency of surface proteins that protect the cells against attack by the body’s complement system. Complement-mediated destruction of the susceptible RBCs results in intravascular hemolysis, the primary clinical manifestation in all PNH patients. Previously, patients with PNH have mainly been managed supportively, with red cell transfusions as required, and treatments such as folate and iron supplementation, anticoagulation for thrombotic disease, and the occasional use of steroids during hemolytic crises. Allogenic stem cell transplantation is currently the only curative option for PNH; however, it is associated with significant morbidity and mortality. Eculizumab therapy is aimed at preventing red cell lysis through blockade of complement activation process and the production of the membrane attack complex. Eculizumab specifically binds to the human complement protein C5 with high affinity (IC₅₀ ＝ 2 nM) and inhibits its cleavage to C5a and C5b, which is a key step in the pathway leading to the membrane attack complex C5b-C9.
Eculizumab has been granted orphan drug status from both the FDA and European regulatory agencies.The most serious adverse reaction associated with eculizumab therapy is meningococcal infections. Eculizumab is contraindicated in patients who are not vaccinated against Neisseria meningitidis or who have N. meningitidis infections. The most common adverse reactions with eculizumab include headache (44%), nasopharyngitis (23%), back pain (19%), and nausea (16%).

Originator

Alexion (US)

Uses

Treatment of autoimmune disease such as rheumatoid arthritis, membranous nephritis, lupus nephritis, dermatomyositis, and autoimmune hemolytic anemias.

brand name

Soliris

General Description

Eculizumab (Soliris) is a monoclonal antibodythat binds to the terminal complement protein C5 inRBCs. This blocks the cleavage of C5 and halts the processof complement-mediated cell destruction of the RBCs.Eculizumab has been shown to be effective in treating PNHand in March 2007 was approved by the FDA for treatingPNH.

Clinical Use

Recombinant monoclonal antibody:
Paroxysmal nocturnal haemoglobinuria (PNH)
Atypical haemolytic uraemic syndrome (aHUS)
Refractory generalized myasthenia gravis (gMG) in patients who are anti-acetylcholine receptor (AChR) antibody-positive (MG)

Metabolism

Human antibodies undergo endocytotic digestion in the cells of the reticuloendothelial system. Eculizumab contains only naturally occurring amino acids and has no known active metabolites. Human antibodies are predominately catabolised by lysosomal enzymes to small peptides and amino acids.

Eculizumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Eculizumab Suppliers

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View Lastest Price from Eculizumab manufacturers

Career Henan Chemica Co

Product: Eculizumab 219685-50-4
Price: US $1.80/KG
Min. Order: 1g
Purity: 98%
Supply Ability: 1KG/10KG/100KG
Release date: 2020-11-02

Hangzhou Huarong Pharm Co., Ltd.

Product: Eculizumab 219685-50-4
Price: US $0.00-0.00/g
Min. Order: 100mg
Purity: 99%
Supply Ability: 100KG
Release date: 2021-09-15

Dideu Industries Group Limited

Product: Eculizumab 219685-50-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-17

219685-50-4, EculizumabRelated Search:

Adalimumab Ustekinumab Nivolumab Bevacizumab Daratumumab OMALIZUMAB Lambrolizumab Dulaglutide Infliximab Rituximab palivizumab Immunoglobulin G4,anti-(human integrin R4) (human-mouse monoclonal AN100226 c4-chain),disulfide with human-mouse monoclonal AN100226 light chain,dimer Atezolizumab Denosumab CETUXIMAB Evolocumab Ramucirumab ipilimumab

Alexion

Eculizumab

H5G1.1

H5G1.1Vhc H5G1.1vlc

Soliris

Unii-A3ulp0F556

ECULIZUMABUM

IMMunoglobulin,anti-(huMan coMpleMent C5 a-chain) (huMan-Mouse Monoclonal 5G1.1 heavy chain), disulfide withhuMan-Mouse Monoclonal 5G1.1 light chain, diMer (9CI)

Eculizumab, stock solution

ECULIZUMAB COMPLEMENT C5 219685-50-4

Eculizumab USP/EP/BP

Research Grade Eculizumab(DHB90002)

inhibit,C5a,C5b,haemolysis,membrane attack complex,humanized monoclonal antibody,Anti-Human C5, Humanized Antibody,Complement System,Eculizumab,complement C5,Inhibitor,MAC

Eculizumab (anti-Complement C5)

219685-50-4