ChemicalBook > CAS DataBase List > tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate

tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate

Product Name
tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate
CAS No.
1095708-32-9
Chemical Name
tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate
Synonyms
Boc-2-AMinopyridine-4-boronic acid pinacol ester;2-boc-aminopyridine-4-borate frequency alcohol ester;2-(tert-Butoxycarbonylamino)pyridine-4-boronic acid pinacol ...;2-(tert-ButoxycarbonylaMino)pyridine-4-boronic acid pinacol ester;(2-((TERT-BUTOXYCARBONYL)AMINO)PYRIDIN-4-YL)BORONIC ACID PINACOL ESTER;tert-butyl N-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate;2-(tert-Butoxycarbonylamino)pyridine-4-boronic acid pinacol ester - [A12056];N-tert-butyl-N-[3-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbaMate;ert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate;tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate
CBNumber
CB02500414
Molecular Formula
C16H25BN2O4
Formula Weight
320.19
MOL File
1095708-32-9.mol
More
Less

tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate Property

Boiling point:
400.7±30.0 °C(Predicted)
Density 
1.10
storage temp. 
Sealed in dry,Store in freezer, under -20°C
pka
12.66±0.70(Predicted)
Appearance
White to off-white Solid
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TRC
Product number
B621203
Product name
Boc-2-aminopyridine-4-boronicAcidPinacolEster
Packaging
100mg
Price
$85
Updated
2021/12/16
TRC
Product number
B621203
Product name
Boc-2-aminopyridine-4-boronicAcidPinacolEster
Packaging
25mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
093840
Product name
tert-Butyl (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate
Purity
95+%
Packaging
250mg
Price
$515
Updated
2021/12/16
AK Scientific
Product number
Y7027
Product name
tert-Butyl4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylcarbamate
Packaging
5g
Price
$736
Updated
2021/12/16
Synthonix
Product number
A12056
Product name
2-(tert-Butoxycarbonylamino)pyridine-4-boronicacidpinacolester
Purity
97.0%
Packaging
10g
Price
$930
Updated
2021/12/16
More
Less

tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate Chemical Properties,Usage,Production

Synthesis

207799-10-8

73183-34-3

1095708-32-9

A reaction mixture was prepared in dimethyl sulfoxide (8 mL) with 2-Boc amine-4-bromopyridine (0.494 g, 1.81 mmol), pinacol ester of bisboronic acid (1.4 g, 5.51 mmol) and potassium acetate (0.535 g, 5.45 mmol). The mixture was purged with nitrogen for 10 min to deoxygenate. Subsequently, [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (0.150 g, 0.184 mmol) was added and again purged with nitrogen for 5 min. Under nitrogen protection, the reaction mixture was heated to 85 °C and stirred for 1 hour. Upon completion of the reaction, the mixture was diluted with ethyl acetate (15 mL) and washed with 0.2 M aqueous hydrochloric acid (10 mL). Note that some of the product may be present in the aqueous layer. Carefully adjust the pH of the aqueous layer to about 6 with saturated aqueous sodium carbonate, and then extract the product from the aqueous layer with ethyl acetate (10 mL). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to afford 2-(Boc-amino)pyridine-4-boronic acid pinacol ester as a white solid (0.44 g, 76% yield). The product was characterized by 1H NMR (DMSO-d6) and LCMS: 1H NMR (DMSO-d6) δ 1.29 (s, 12H), 1.45 (s, 9H), 7.15-7.17 (d, 1H), 8.07 (s, 1H), 8.24-8.25 (d, 1H), 9.77 (s, 1H); LCMS Rt = 0.68 min, MS m/z 183.1 [M+H]+.

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 13, p. 5613 - 5637
[2] Patent: WO2012/4714, 2012, A2. Location in patent: Page/Page column 62
[3] Patent: US2014/194443, 2014, A1. Location in patent: Paragraph 0543-0545
[4] Patent: WO2014/108337, 2014, A1. Location in patent: Page/Page column 69; 70
[5] Patent: US2010/179154, 2010, A1. Location in patent: Page/Page column 29

tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate Suppliers

China 97 India 1 United States 7 Global 105
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
QINGDAO CARELONGPHARMATECH CO.,LTD
Tel
0532-0532-88191853 13061484198
Fax
+86-532-88191853
Email
sales@carelongchem.com
Country
China
ProdList
437
Advantage
57
Wuhan ariel chemical Co., LTD.
Tel
18986259541
Fax
027-87840182
Email
sales@3stc.com
Country
China
ProdList
3763
Advantage
58
Pharmsynth Pharmaceutical (Chengdu) Technology Co.,LTD
Tel
15528092102
Fax
On Line QQ 2415375924
Email
Pharmsynth@hotmail.com
Country
China
ProdList
116
Advantage
60
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
shanghai aokchem co., ltd
Tel
021-68712331 39130253
Fax
18621350903
Email
aokchem@gmail.com
Country
China
ProdList
332
Advantage
58
Wuhan Kaymke Chemical Co., Ltd.,
Tel
027-027-87342388 18086026008
Fax
027-87342388
Email
sales@kaymke.com
Country
China
ProdList
3731
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
15026594951
Fax
0556-5030632
Email
rs@raise-chem.com
Country
China
ProdList
4454
Advantage
55
More
Less

View Lastest Price from tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate manufacturers

Career Henan Chemical Co
Product
tert-butyl N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate 1095708-32-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10 tons/month
Release date
2020-01-09

1095708-32-9, tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate Related Search:

1-(BOC-AMINOMETHYL)-3,3-DFLUOROCYCLOBUTANE-1-METHAMINE 3,5-DIMETHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER 4-Isoquinolineboronic acid 4-CHLORO-(N-BOC)ANILINE 97 (4-Bromo-2-fluoro-5-methyl-phenyl)-carbamic acid tert-butyl ester N-BOC-4-broMo-3-Methylaniline 2-BOC-AMINO-4-BROMOTOLUENE (6-BROMO-2-PYRIDINYL)-CARBAMIC ACID,1,1-DIMETHYLETHYL ESTER (5-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER CARBAMIC ACID, (5-BROMO-4-METHYL-2-PYRIDINYL)-,1,1-DIMETHYLETHYL ESTER (2-Bromo-5-methyl-phenyl)-carbamic acid tert-butyl ester tert-butyl 4-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylcarbaMate Tert-butyl (4-bromo-2,3-dimethylphenyl)carbamate tert-butyl N-[3-(4-amino-1H-pyrazol-1-yl)propyl]carbamate N-(3-Iodo-5-methylpyridin-2-yl)pivalamide tert-Butyl (2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)biscarbamate Carbamic acid, N-(4-bromo-2,5-difluorophenyl)-, 1,1-dimethylethyl ester Carbamic acid, N-(4-bromo-2,6-difluorophenyl)-, 1,1-dimethylethyl ester

  • tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate
  • N-tert-butyl-N-[3-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbaMate
  • 2-(tert-ButoxycarbonylaMino)pyridine-4-boronic acid pinacol ester
  • Boc-2-AMinopyridine-4-boronic acid pinacol ester
  • tert-butyl N-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate
  • [4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-carbamic acid tert-butyl ester 97%
  • (2-((TERT-BUTOXYCARBONYL)AMINO)PYRIDIN-4-YL)BORONIC ACID PINACOL ESTER
  • tert-butyl (4-(hydroxy((3-hydroxy-2,3-dimethylbutan-2-yl)oxy)boranyl)pyridin-2-yl)carbamate
  • tert-butyl N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate
  • Carbamic acid, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-, 1,1-dimethylethyl ester
  • 2-(tert-Butoxycarbonylamino)pyridine-4-boronic acid pinacol ...
  • 1,1-Dimethylethyl N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]carbamate
  • 2-boc-aminopyridine-4-borate frequency alcohol ester
  • ert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate
  • 2-(tert-Butoxycarbonylamino)pyridine-4-boronic acid pinacol ester - [A12056]
  • 1095708-32-9