(5-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER

Product Name: (5-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.: 361550-43-8
Chemical Name: (5-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms: Zinc04352716;5-(Boc-amino)-3-bromopyridine;3-(Boc-amino)-5-bromopyridine;5-Bromo-3-(Boc-amino)-pyridine;3-(Boc-amino)-5-bromopyridine 97%;tert-Butyl 5-bromopyridine-3-carbamate;TERT-BUTYL 5-BROMOPYRIDIN-3-YLCARBAMATE;ert-Butyl(5-bromopyridin-3-yl)carbamate;tert-butyl N-(5-bromo-3-pyridyl)carbamate;tert-Butyl N-(5-broMopyridin-3-yl)carbaMate
CBNumber: CB1310764
Molecular Formula: C10H13BrN2O2
Formula Weight: 273.13
MOL File: 361550-43-8.mol

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(5-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Property

Melting point:: 143-148°C
Boiling point:: 286.5±25.0 °C(Predicted)
Density: 1.453±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 12.26±0.70(Predicted)
form: solid

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 740330
Product name: 3-(Boc-amino)-5-bromopyridine
Purity: 97%
Packaging: 10g
Price: $206
Updated: 2023/06/20

Sigma-Aldrich

Product number: 740330
Product name: 3-(Boc-amino)-5-bromopyridine
Purity: 97%
Packaging: 1g
Price: $34.8
Updated: 2022/05/15

Sigma-Aldrich

Product number: ADE000362
Product name: 3-(Boc-amino)-5-bromopyridine
Purity: Aldrich
Packaging: 1g
Price: $463
Updated: 2023/06/20

Biosynth Carbosynth

Product number: FB139920
Product name: tert-Butyl (5-bromopyridin-3-yl)carbamate
Packaging: 25g
Price: $500
Updated: 2021/12/16

AK Scientific

Product number: W5761
Product name: tert-Butyl(5-bromopyridin-3-yl)carbamate
Packaging: 25g
Price: $427
Updated: 2021/12/16

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(5-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

20826-04-4

75-65-0

361550-43-8

5-Bromonicotinic acid (10 g, 49.5 mmol) was dissolved in tert-butanol (100 mL) at 20 °C and triethylamine (15.2 g, 150 mmol) and DPPA (20.4 g, 74 mmol) were added. The mixture was stirred in toluene (100 mL) at 65 °C for 40 min, followed by heating to 100 °C under nitrogen protection for 22 h of reaction. After completion of the reaction, the mixture was cooled and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using ethyl acetate/hexane as eluent to afford tert-butyl 5-bromopyridine-3-carboxylate (10.52 g, 78%) as a white solid.1H NMR (300 MHz, CDCl3) δ 8.32 (m, 3H), 6.97 (brs, 1H), 1.53 (s, 9H); MS (ES) m/z: 273, 275 (M+H+). Calculated analytical value C10H13N2O2Br: C, 43.98; H, 4.80; N, 10.26. Measured value: C, 43.88; H, 4.52; N, 10.20.

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 2, p. 695 - 709
[2] Journal of Medicinal Chemistry, 2005, vol. 48, # 14, p. 4535 - 4546
[3] Patent: WO2004/9562, 2004, A1. Location in patent: Page 31-33
[4] Patent: WO2006/82373, 2006, A1. Location in patent: Page/Page column 107
[5] Patent: US2008/194552, 2008, A1. Location in patent: Page/Page column 31

(5-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(5-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Suppliers

China 102 India 1 United Kingdom 1 United States 19 Global 123

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View Lastest Price from (5-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER manufacturers

Dideu Industries Group Limited

Product: (5-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER 361550-43-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-23

Shaanxi Dideu Medichem Co. Ltd

Product: (5-Bromo-pyridin-3-yl)-carbamic acid tert-butyl ester 361550-43-8
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-12

361550-43-8, (5-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

4-CHLORO-(N-BOC)ANILINE 97 (4-Bromo-2-fluoro-5-methyl-phenyl)-carbamic acid tert-butyl ester N-BOC-4-broMo-3-Methylaniline 2-BOC-AMINO-4-BROMOTOLUENE (6-BROMO-2-PYRIDINYL)-CARBAMIC ACID,1,1-DIMETHYLETHYL ESTER tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate (5-NITRO-1,2-BENZISOXAZOL-3-YL)CARBAMIC ACID 1,1-DIMETHYL ETHYL ESTER RARECHEM AL BW 2469 2-Pyridinemethanol,5-chloro-(9CI) (2-Bromo-5-methyl-phenyl)-carbamic acid tert-butyl ester CARBAMIC ACID, (5-BROMO-4-METHYL-2-PYRIDINYL)-,1,1-DIMETHYLETHYL ESTER (5-Bromo-1H-indol-3-yl)-acetic acid methyl ester (5-Bromopyrimidin-2-yl)acetic acid ethyl ester tert-butyl 4-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylcarbaMate Carbamic acid, N-(4-bromo-2,5-difluorophenyl)-, 1,1-dimethylethyl ester N-(3-Iodo-5-methylpyridin-2-yl)pivalamide tert-Butyl (2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)biscarbamate Carbamic acid, N-(4-bromo-2,6-difluorophenyl)-, 1,1-dimethylethyl ester

(5-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER

TERT-BUTYL 5-BROMOPYRIDIN-3-YLCARBAMATE

tert-Butyl N-(5-broMopyridin-3-yl)carbaMate

3-(Boc-amino)-5-bromopyridine

5-(Boc-amino)-3-bromopyridine

tert-Butyl 5-bromopyridine-3-carbamate

5-Bromo-3-(Boc-amino)-pyridine

Carbamic acid, (5-bromo-3-pyridinyl)-, 1,1-dimethylethyl ester

Zinc04352716

Carbamic acid, N-(5-bromo-3-pyridinyl)-, 1,1-dimethylethyl ester

3-(Boc-amino)-5-bromopyridine 97%

ert-Butyl(5-bromopyridin-3-yl)carbamate

(5-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER ISO 9001：2015 REACH

tert-butyl N-(5-bromo-3-pyridyl)carbamate

361550-43-8