(6-BROMO-2-PYRIDINYL)-CARBAMIC ACID,1,1-DIMETHYLETHYL ESTER

Product Name: (6-BROMO-2-PYRIDINYL)-CARBAMIC ACID,1,1-DIMETHYLETHYL ESTER
CAS No.: 344331-90-4
Chemical Name: (6-BROMO-2-PYRIDINYL)-CARBAMIC ACID,1,1-DIMETHYLETHYL ESTER
Synonyms: Cholest-5-en-3-ol,(7α)-;2-(BOC-AMino)-6-broMopyridine;N-Boc-2-AMino-6-broMopyridine;6-BROMO-2-(N-BOC AMINO) PYRIDNE;tert-Butyl 6-bromopyridin-2-ylcarbamate;t-butyl N-(6-bromo-2-pyridinyl)carbamate;6-BROMO-2-TERT-BUTOXYCARBONYLAMINO-PYRIDINE;tert-butyl N-(6-bromopyridin-2-yl)carbamate;Benzenemethanesulfonylchloride,9-(trifluoromethyl)-;(6-BroMo-pyridin-2-yl)-carbaMic acid tert-butyl ester
CBNumber: CB4218474
Molecular Formula: C10H13BrN2O2
Formula Weight: 273.13
MOL File: 344331-90-4.mol

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(6-BROMO-2-PYRIDINYL)-CARBAMIC ACID,1,1-DIMETHYLETHYL ESTER Property

Boiling point:: 299.3±25.0 °C(Predicted)
Density: 1.453±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 11.89±0.70(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B603125
Product name: 2-(Boc-amino)-6-bromopyridine
Packaging: 250mg
Price: $70
Updated: 2021/12/16

Apolloscientific

Product number: OR959588
Product name: 2-(Boc-Amino)-6-bromopyridine
Packaging: 1g
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: OR959588
Product name: 2-(Boc-Amino)-6-bromopyridine
Packaging: 250mg
Price: $34
Updated: 2021/12/16

Apolloscientific

Product number: OR959588
Product name: 2-(Boc-Amino)-6-bromopyridine
Packaging: 5g
Price: $229
Updated: 2021/12/16

Matrix Scientific

Product number: 081258
Product name: tert-Butyl 6-bromopyridin-2-ylcarbamate
Purity: 97%
Packaging: 1g
Price: $341
Updated: 2021/12/16

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(6-BROMO-2-PYRIDINYL)-CARBAMIC ACID,1,1-DIMETHYLETHYL ESTER Chemical Properties,Usage,Production

Synthesis

19798-81-3

24424-99-5

344331-90-4

Step 1. Synthesis of 6-bromo-2-Boc-aminopyridine: To a solution of dichloromethane (24 mL) containing 6-bromopyridin-2-amine (3 g, 17.34 mmol), triethylamine (3.14 mL, 22.54 mmol), and DMAP (0.424 g, 3.47 mmol) was slowly added a solution of dichloromethane (6 mL) containing di-tert-butyl dicarbonate (4.83 mL, 20.81 mmol). 20.81 mmol) to a solution of dichloromethane (6 mL). The reaction mixture was stirred at room temperature for about 24 hours. Upon completion of the reaction, the reaction mixture was diluted with water, saturated saline and ethyl acetate. The aqueous layer was separated and extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography to give 6-bromo-2-tert-butoxycarbonylaminopyridine as a white solid. Yield: 1.67 g. LCMS (m/z): 274.9 [M+H]+; Retention time: 0.54 min (major peak), 0.95 min.

References

[1] Patent: WO2012/101066, 2012, A1. Location in patent: Page/Page column 77
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 24, p. 8709 - 8715
[3] Patent: WO2017/205536, 2017, A2. Location in patent: Page/Page column 193; 194
[4] Patent: WO2004/113331, 2004, A1. Location in patent: Page 68
[5] Patent: WO2006/53791, 2006, A2. Location in patent: Page/Page column 39-40

(6-BROMO-2-PYRIDINYL)-CARBAMIC ACID,1,1-DIMETHYLETHYL ESTER Preparation Products And Raw materials

Raw materials

Ammonium hydroxide 2,6-Dibromopyridine Acetic anhydride

Preparation Products

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(6-BROMO-2-PYRIDINYL)-CARBAMIC ACID,1,1-DIMETHYLETHYL ESTER Suppliers

China 87 India 4 United Kingdom 1 United States 12 Global 104

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344331-90-4, (6-BROMO-2-PYRIDINYL)-CARBAMIC ACID,1,1-DIMETHYLETHYL ESTERRelated Search:

Carbamic acid, N-(4-bromo-2,6-difluorophenyl)-, 1,1-dimethylethyl ester Tert-butyl (4-bromo-2,3-dimethylphenyl)carbamate 4-CHLORO-(N-BOC)ANILINE 97 (4-Bromo-2-fluoro-5-methyl-phenyl)-carbamic acid tert-butyl ester N-BOC-4-broMo-3-Methylaniline 2-BOC-AMINO-4-BROMOTOLUENE Carbamic acid, N-(4-bromo-2,5-difluorophenyl)-, 1,1-dimethylethyl ester (5-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER N-(3-Iodo-5-methylpyridin-2-yl)pivalamide tert-Butyl (2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)biscarbamate tert-Butyl[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin -2-yl]carbamate (2-Bromo-5-methyl-phenyl)-carbamic acid tert-butyl ester CARBAMIC ACID, (5-BROMO-4-METHYL-2-PYRIDINYL)-,1,1-DIMETHYLETHYL ESTER TERT-BUTYL 4-BROMO-2-CHLOROPHENYLCARBAMATE Carbamic acid, (3-chloro-4-fluorophenyl)-, 1,1-dimethylethyl ester 2-(Boc-amino)-5-bromopyridine tert-butyl 4-Methyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylcarbaMate tert-butyl (4-Bromo-2,6-difluorophenyl)biscarbamate

6-BROMO-2-TERT-BUTOXYCARBONYLAMINO-PYRIDINE

(6-BROMO-2-PYRIDINYL)-CARBAMIC ACID,1,1-DIMETHYLETHYL ESTER

N-Boc-2-AMino-6-broMopyridine

Carbamic acid,N-(6-bromo-2-pyridinyl)-,1,1-dimethylethyl ester

tert-Butyl 6-bromopyridin-2-ylcarbamate

t-butyl N-(6-bromo-2-pyridinyl)carbamate

(6-BroMo-pyridin-2-yl)-carbaMic acid tert-butyl ester

2-(BOC-AMino)-6-broMopyridine

tert-butyl N-(6-bromopyridin-2-yl)carbamate

Cholest-5-en-3-ol,(7α)-

Benzenemethanesulfonylchloride,9-(trifluoromethyl)-

6-BROMO-2-(N-BOC AMINO) PYRIDNE

344331-90-4

pharmacetical