AEE788

ChemicalBook > CAS DataBase List > AEE788

Description

Product Name: AEE788
CAS No.: 497839-62-0
Chemical Name: AEE788
Synonyms: AEE788;CS-375;NVP-AEE788;AEE 788AEE-788;AEE788 USP/EP/BP;AEE788 (NVP-AEE788);AEE788 (NVP-AEE788);AEE-788;AEE 788;NVP-AEE 788;(R)-6-(4-((4-Ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4;6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl) -N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;(R)-6-(4-((4-Ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CBNumber: CB02500944
Molecular Formula: C27H32N6
Formula Weight: 440.58
MOL File: 497839-62-0.mol

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AEE788 Property

storage temp.: -20°C
solubility: ≥22.05 mg/mL in DMSO; insoluble in H2O; ≥14.4 mg/mL in EtOH with ultrasonic
form: powder
color: white to beige
CAS DataBase Reference: 497839-62-0

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Safety

RTECS: UY8836200

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1400
Product name: AEE788
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $129
Updated: 2022/05/15

Cayman Chemical

Product number: 18416
Product name: AEE788
Purity: ≥98%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 18416
Product name: AEE788
Purity: ≥98%
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 18416
Product name: AEE788
Purity: ≥98%
Packaging: 10mg
Price: $220
Updated: 2024/03/01

Cayman Chemical

Product number: 18416
Product name: AEE788
Purity: ≥98%
Packaging: 25mg
Price: $456
Updated: 2024/03/01

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AEE788 Chemical Properties,Usage,Production

Description

AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2.

Description

AEE788 is an inhibitor of both epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) receptor tyrosine kinase family members. It can inhibit EGFR and VEGFR tyrosine kinases with IC₅₀ values of 2, 6, 77, and 59 nM for EGFR, ErbB2, KDR, and FLT1, respectively. AEE788 demonstrates antiproliferative activity against a range of EGFR and ErbB2-overexpressing cell lines and can inhibit the proliferation of EGF- and VEGF-stimulated human umbilical vein endothelial cells. It also has been shown to have antitumor and anti-angiogenic activity in numerous animal models of cancer.

Uses

AEE788 is a novel multitargeted human epidermal receptor (HER) 1/2 and vascular endothelial growth factor receptor (VEGFR) 1/2 receptor family tyrosine kinases inhibitor with IC50 of 2, 6, 77, 59 nM for EGFR, ErbB2, KDR, and Flt-1.

Uses

AEE788 is an inhibitor of both epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) receptor tyrosine kinase family members. It can inhibit EGFR and VEGFR tyrosine kinases with IC50 values of 2, 6, 77, and 59 nM for EGFR, ErbB2, KDR, and FLT1, respectively. AEE788 demonstrates antiproliferative activity against a range of EGFR and ErbB2-overexpressing cell lines and can inhibit the proliferation of EGF- and VEGF-stimulated human umbilical vein endothelial cells. It also has been shown to have antitumor and anti-angiogenic activity in numerous animal models of cancer.[Cayman Chemical]

Uses

A novel dual receptor tyrosine kinase inhibitor of the EGF and the VEGF receptor, for treatment of human HCC cell lines and in a s.c. xenograft model.

Definition

ChEBI: AEE788 is a 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine which adopts an R-configuration. It is a potent inhibitor of human EGFR, VEGFR and HER2 receptor tyrosine kinases and exhibits anticancer and antiangiogenic activity. It has a role as an epidermal growth factor receptor antagonist, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, an antineoplastic agent, an angiogenesis inhibitor, a trypanocidal drug and an apoptosis inducer.

storage

Store at -20°C

References

[1] venkatesan p, bhutia sk, singh ak et al. aee788 potentiates celecoxib-induced growth inhibition and apoptosis in human colon cancer cells. life sci. 2012 oct 22;91(15-16):789-99.
[2] park yw, younes mn, jasser sa et al. aee788, a dual tyrosine kinase receptor inhibitor, induces endothelial cell apoptosis in human cutaneous squamous cell carcinoma xenografts in nude mice. clin cancer res. 2005 mar 1;11(5):1963-73.
[3] traxler p, allegrini pr, brandt r et al. aee788: a dual family epidermal growth factor receptor/erbb2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. cancer res. 2004 jul 15;64(14):4931-41.
[4] evans ah, pancholi s, farmer i et al. egfr/her2 inhibitor aee788 increases er-mediated transcription in her2/er-positive breast cancer cells but functions synergistically with endocrine therapy. br j cancer. 2010 apr 13;102(8):1235-43.
[5] meco d, servidei t, zannoni gf et al. dual inhibitor aee788 reduces tumor growth in preclinical models of medulloblastoma. transl oncol. 2010 oct 1;3(5):326-35.

AEE788 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AEE788 manufacturers

Career Henan Chemical Co

Product: AEE788 497839-62-0
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-12

497839-62-0, AEE788Related Search:

HEPES Ceritinib MK-2206 2HCl Fingolimod hydrochloride Lapatinib Ditosylate XL147 Canertinib

AEE788 (NVP-AEE788);AEE-788;AEE 788;NVP-AEE 788

(R)-6-(4-((4-Ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4

AEE788

(R)-6-(4-((4-Ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, 6-[4-[(4-ethyl-1-piperazinyl)Methyl]phenyl]-N-[(1R)-1-phenylethyl]-

[6-[4-(4-ethyl-piperazine-1-ylMethyl)-phenyl]-7H-pyrrolo[2,3-d]pyrinidinpyriMidin-4-yl]-((R)-1-phenyl-ethyl)-aMine

AEE 788AEE-788

[6-[4-[(4-Ethylpiperazin-1-yl)Methyl]phenyl]-7H-pyrrolo[2,3-d]pyriMidin -4-yl]-((R)-1-phenylethyl)aMine

AEE788 (NVP-AEE788)

NVP-AEE788

6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine AEE 788

6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl) -N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

6-(4-((4-ethyl-1-piperazinyl)methyl)phenyl)-N-((1R)-1-phenylethyl)-1H-Pyrrolo(2,3-D)pyrimidin-4-amine

CS-375

AEE788 USP/EP/BP

497839-62-0

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