Methyl-5-(bromomethyl)pyrazine-2-carboxylate

Product Name: Methyl-5-(bromomethyl)pyrazine-2-carboxylate
CAS No.: 193966-70-0
Chemical Name: Methyl-5-(bromomethyl)pyrazine-2-carboxylate
Synonyms: pyrazine-2-carboxylate;Methyl 5-(bromomethyl);Methyl-5-(bromomethyl)pyrazine-2-carboxylate
CBNumber: CB02504856
Molecular Formula: C7H7BrN2O2
Formula Weight: 231.04668
MOL File: 193966-70-0.mol

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Methyl-5-(bromomethyl)pyrazine-2-carboxylate Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid
InChI: InChI=1S/C7H7BrN2O2/c1-12-7(11)6-4-9-5(2-8)3-10-6/h3-4H,2H2,1H3
InChIKey: OIGRHUBIDWZLHR-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)=NC=C(CBr)N=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M296965
Product name: Methyl5-(Bromomethyl)pyrazine-2-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: W4143
Product name: Methyl-5-(bromomethyl)pyrazine-2-carboxylate
Packaging: 100mg
Price: $79
Updated: 2021/12/16

AK Scientific

Product number: W4143
Product name: Methyl-5-(bromomethyl)pyrazine-2-carboxylate
Packaging: 250mg
Price: $118
Updated: 2021/12/16

AK Scientific

Product number: J96947
Product name: Methyl-5-(bromomethyl)pyrazine-2-carboxylate
Packaging: 1g
Price: $244
Updated: 2021/12/16

Matrix Scientific

Product number: 074626
Product name: Methyl 5-(bromomethyl)pyrazine-2-carboxylate
Purity: 95+%
Packaging: 500mg
Price: $305
Updated: 2021/12/16

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Methyl-5-(bromomethyl)pyrazine-2-carboxylate Chemical Properties,Usage,Production

Synthesis

41110-33-2

193966-70-0

Methyl 5-methylpyrazine-2-carboxylate (0.5 g, 3.28 mmol) was dissolved in acetic acid (5 mL) at room temperature and bromine (0.9 mL, 3.6 mmol) was added slowly. The reaction mixture was heated to 80 °C and kept for 45 min. Upon completion of the reaction, it was concentrated under reduced pressure to remove the acetic acid. The residue was adjusted to basicity with saturated sodium bicarbonate solution and subsequently extracted with ethyl acetate. The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford methyl 5-bromomethylpyrazine-2-carboxylate (0.3 g, 40% yield) as a brown liquid using hexane solution of 20% ethyl acetate as eluent. Mass spectrometry analysis (ESI): calculated value [M+H]+ 230.97, measured value [M+H]+ 231.0.

References

[1] Patent: WO2015/48503, 2015, A2. Location in patent: Paragraph 0138
[2] Patent: WO2017/18803, 2017, A1. Location in patent: Paragraph 2039; 2040; 2041
[3] Patent: EP1389460, 2004, A1. Location in patent: Page/Page column 36
[4] ACS Combinatorial Science, 2012, vol. 14, # 3, p. 164 - 169
[5] Medicinal Chemistry Research, 2015, vol. 24, # 7, p. 2986 - 2992

Methyl-5-(bromomethyl)pyrazine-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl-5-(bromomethyl)pyrazine-2-carboxylate Suppliers

China 41 India 1 United States 6 Global 48

Pure Chemistry Scientific Inc.

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Combi-Blocks Inc.

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Matrix Scientific

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View Lastest Price from Methyl-5-(bromomethyl)pyrazine-2-carboxylate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Methyl 5-(bromomethyl)pyrazine-2-carboxylate 193966-70-0
Price: US $1.10-9.90/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-18

Career Henan Chemical Co

Product: Methyl-5-(bromomethyl)pyrazine-2-carboxylate 193966-70-0
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-14

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Methyl-5-(bromomethyl)pyrazine-2-carboxylate

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pyrazine-2-carboxylate

193966-70-0