methyl 4-cyano-2-methylbenzoate
Uses- Product Name
- methyl 4-cyano-2-methylbenzoate
- CAS No.
- 103261-67-2
- Chemical Name
- methyl 4-cyano-2-methylbenzoate
- Synonyms
- methyl 4-cyano-2-methylbenzoate;methyl 4-cyano-2-methylbenzoate 97%;4-cyano-2-methylBenzoic acid methyl ester;Benzoic acid, 4-cyano-2-methyl-, methyl ester;Methyl4-cyano2-methylbenzoateMethyl4-cyano2-methylbenzoate
- CBNumber
- CB02514738
- Molecular Formula
- C10H9NO2
- Formula Weight
- 175.18
- MOL File
- 103261-67-2.mol
methyl 4-cyano-2-methylbenzoate Property
- Boiling point:
- 302.7±30.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to brown Solid
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B495053
- Product name
- Methyl4-Cyano-2-methylbenzoate
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 0775AA
- Product name
- Methyl4-cyano-2-methylbenzoate
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
- Product number
- OR916717
- Product name
- Methyl 4-cyano-2-methylbenzoate
- Packaging
- 1g
- Price
- $176
- Updated
- 2021/12/16
- Product number
- CHM0393161
- Product name
- METHYL-4-CYANO-2-METHYLBENZOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.3
- Updated
- 2021/12/16
- Product number
- OR916717
- Product name
- Methyl 4-cyano-2-methylbenzoate
- Packaging
- 5g
- Price
- $649
- Updated
- 2021/12/16
methyl 4-cyano-2-methylbenzoate Chemical Properties,Usage,Production
Uses
Methyl 4-cyano-2-methylbenzoate is a carboxylate derivative and can be used as an intermediate in organic synthesis.
Synthesis
557-21-1
99548-55-7
103261-67-2
Example 3.6: Preparation of methyl 4-bromo-2-methylbenzoate; Methyl 4-bromo-2-methylbenzoate (108 g, 471 mmol) was dissolved in N,N-dimethylformamide (4 L) under nitrogen protection followed by the addition of zinc(II) cyanide (88.5 g, 753.6 mmol) and tetrakis(triphenylphosphine)palladium(0) (65 g, 56.60 mmol). The reaction mixture was stirred at 100 °C for 16 hours. After completion of the reaction, the reaction mixture was diluted with toluene for phase separation. The aqueous phase was extracted twice with toluene. All organic phases were combined and washed sequentially with brine and saturated aqueous ammonium hydroxide solution, dried over anhydrous sodium sulfate and concentrated. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate/cyclohexane, 1:5, v/v) to afford methyl 4-cyano-2-methylbenzoate (73 g, 89% yield).1H NMR (400 MHz, CDCl3): δ 7.78 (d, 1H), 7.52 (m, 2H), 3.92 (s, 3H), 2.62 (s, 3H).
References
[1] Patent: WO2010/127926, 2010, A1. Location in patent: Page/Page column 46
[2] Patent: WO2010/127928, 2010, A1. Location in patent: Page/Page column 32
[3] ChemBioChem, 2016, vol. 17, # 8, p. 759 - 767
[4] Patent: US2012/129832, 2012, A1. Location in patent: Page/Page column 11-12
[5] Patent: WO2013/75083, 2013, A1. Location in patent: Paragraph 00467; 00469
methyl 4-cyano-2-methylbenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
methyl 4-cyano-2-methylbenzoate Suppliers
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 010-59484199 18611897322
- sales@eternalchem.com
- Country
- China
- ProdList
- 4383
- Advantage
- 60
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 025-85205967 13951876367
- Fax
- 025-85205967
- shengsaichem@163.com
- Country
- China
- ProdList
- 818
- Advantage
- 58
- Tel
- 0512-62857507
- Fax
- +86-512-62857507
- sales@sinorarechem.com
- Country
- China
- ProdList
- 998
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 15210642910
- moon5.1days@126.com
- Country
- China
- ProdList
- 202
- Advantage
- 56
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 0571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 14912
- Advantage
- 59
- Tel
- 13598610367
- Fax
- QQ:2468833170
- 2841375912@qq.com
- Country
- China
- ProdList
- 2789
- Advantage
- 52
- Tel
- 025-66028182 18626450290
- yftan@aikonchem.com
- Country
- China
- ProdList
- 16679
- Advantage
- 50
- Tel
- 13912302692 13912302692;
- Fax
- 0519-88064678
- sales@anxuanchem.com
- Country
- China
- ProdList
- 4828
- Advantage
- 58
- Tel
- 18-086626237 18086626237
- Fax
- qq:2693528373
- 2693528373@qq.com
- Country
- China
- ProdList
- 2973
- Advantage
- 56
- Tel
- 13817485796
- Fax
- QQ:895624079
- tim@wisacheampharm.com
- Country
- China
- ProdList
- 3593
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 0317-5296180 15533709196
- Fax
- 0317-5106596
- sale@enkepharma.com
- Country
- China
- ProdList
- 2267
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 18621295758
- Fax
- -QQ:1449085402
- 1449085402@qq.com
- Country
- China
- ProdList
- 1951
- Advantage
- 55
- Tel
- 0539-6362799 20）
- Fax
- 0539-6362799（To 20）
- Country
- China
- ProdList
- 9998
- Advantage
- 58
- Tel
- +86-（0）57185586718; +8613336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29735
- Advantage
- 60
- Tel
- 400-8210725 400821072
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 028-87439248 19150327610
- Fax
- 028-87439248
- 553691721@qq.com
- Country
- China
- ProdList
- 64
- Advantage
- 58
- Tel
- 400-6387771-6039 18920764717
- sales@heowns.com
- Country
- China
- ProdList
- 23771
- Advantage
- 60
- Tel
- 13370351217 kungfu1217@1
- Fax
- QQ1400885609
- kungfu1217@163.com
- Country
- China
- ProdList
- 2720
- Advantage
- 58
- Tel
- 17317130613
- Fax
- QQ3358272972
- 3358272972@qq.com
- Country
- China
- ProdList
- 3277
- Advantage
- 58
- Tel
- 021-000000
- admin@jingshipharmatech.com
- Country
- China
- ProdList
- 9852
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 021-33758897
- sales@scochem.com
- Country
- China
- ProdList
- 1596
- Advantage
- 58
- Tel
- +86-188369842 +86-15618151133
- Fax
- QQ188369842
- 188369842@qq.com
- Country
- China
- ProdList
- 1959
- Advantage
- 58
- Tel
- 13062833949
- Fax
- QQ: 2073772974
- fred.wen@crcorporation.cn
- Country
- China
- ProdList
- 853
- Advantage
- 58
- Tel
- 0512-65816829 18662214788
- Fax
- 0512-65816829
- info@rovathin.com.cn
- Country
- China
- ProdList
- 9987
- Advantage
- 58
- Tel
- +86-400-0216110 +86-15958047586
- Fax
- 0086-21-33275002
- sales@allfluoro.com
- Country
- China
- ProdList
- 11385
- Advantage
- 58
- Tel
- +8613062833949
- fred.wen@crcorporation.cn
- Country
- China
- ProdList
- 8645
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
- Tel
- +86-27-50766799 +8618062016861
- contact@labnetwork.com
- Country
- China
- ProdList
- 19987
- Advantage
- 58
- Tel
- +8617013299288
- dj@sgtlifesciences.com
- Country
- China
- ProdList
- 12373
- Advantage
- 58
- Tel
- +86-0086-577-64498589 +86-15355981851
- Fax
- 0086-577-56994596
- sales@win-winchemical.com
- Country
- China
- ProdList
- 14359
- Advantage
- 58
- Tel
- 0531-0531-69900633 19963472814
- changyuan20@163.com
- Country
- China
- ProdList
- 2742
- Advantage
- 58
- Tel
- 0371-63284658 18135795563
- Fax
- QQ:2885349392
- 2885349392@qq.com
- Country
- China
- ProdList
- 9989
- Advantage
- 58
- Tel
- 15021845385
- 765325601@qq.com
- Country
- China
- ProdList
- 3609
- Advantage
- 58
- Tel
- 021-50795510 4000665055
- sales@accelachem.com
- Country
- China
- ProdList
- 10467
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- +86-021-021-50872116 +8613122107989
- contact@fuxinpharm.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- +8613580539051
- joe@yuhengpharm.com
- Country
- CHINA
- ProdList
- 21142
- Advantage
- 58
- Tel
- 0573-0573-82672231 13757365595
- Fax
- QQ：715584339
- regen_chemical1@163.com
- Country
- China
- ProdList
- 4839
- Advantage
- 58
- Tel
- 15002184385 15021598081 15002184385
- product001@xiushipharm.com
- Country
- China
- ProdList
- 4719
- Advantage
- 58
- Tel
- 18252089365
- Krain_kerun@163.com
- Country
- China
- ProdList
- 2507
- Advantage
- 58
- Tel
- 17366295326
- Fax
- QQ360829978
- puxinpharma_2017@126.com
- Country
- China
- ProdList
- 2444
- Advantage
- 58
- Tel
- +86-02787215551 +86-19945035818
- Fax
- 027-87215551
- 2936752263@qq.com
- Country
- China
- ProdList
- 7984
- Advantage
- 58