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Di-tert-butyl Chloromethyl Phosphate

Product Name
Di-tert-butyl Chloromethyl Phosphate
CAS No.
229625-50-7
Chemical Name
Di-tert-butyl Chloromethyl Phosphate
Synonyms
Di-tert-butyl Chloromethyl Phosphate;Phosphoric acid di-tert-butyl chloromethyl ester;Fostemsavir-SM;Foscarbidopa Impurity 20;Di-t-butyl chloromethyl phosphate;ditetrabutyl chloromethyl phosphate;Chloromethyl di-tert-butyl phosphate;Di-tert-butyl chloromethyl phosphate 95%;Di tertiary butyl chloromethyl phosphite;PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER
CBNumber
CB02515861
Molecular Formula
C9H20ClO4P
Formula Weight
258.68
MOL File
229625-50-7.mol
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Di-tert-butyl Chloromethyl Phosphate Property

Boiling point:
272.9±23.0 °C(Predicted)
Density 
1.115±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Benzene (Slightly), Methanol (Slightly)
form 
clear liquid
color 
Colorless to Light yellow
Stability:
Moisture Sensitive
InChI
InChI=1S/C9H20ClO4P/c1-8(2,3)13-15(11,12-7-10)14-9(4,5)6/h7H2,1-6H3
InChIKey
LNJAJHJFSKUCIR-UHFFFAOYSA-N
SMILES
P(OC(C)(C)C)(OC(C)(C)C)(OCCl)=O
CAS DataBase Reference
229625-50-7
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36/37
HS Code 
29199000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D428028
Product name
Di-tert-butylChloromethylPhosphate(stabilizedwithK2CO3)
Packaging
50mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD137343
Product name
Di-tert-butyl chloromethyl phosphate
Packaging
500mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
092558
Product name
Di-tert-butyl (chloromethyl) phosphate (stabilized with potassium carbonate)
Purity
95+%
Packaging
1g
Price
$87
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD137343
Product name
Di-tert-butyl chloromethyl phosphate
Packaging
1g
Price
$95
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD137343
Product name
Di-tert-butyl chloromethyl phosphate
Packaging
2g
Price
$160
Updated
2021/12/16
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Di-tert-butyl Chloromethyl Phosphate Chemical Properties,Usage,Production

Description

Di-tert-butyl (chloromethyl) phosphate has become one of the most common reagents to prepare phosphon-oxymethyl pro-drugs, generally by direct alkylation of hydroxyl or amino groups. Its synthesis was first reported in 1999 via a reaction of di-tert-butyl tetramethylammonium phosphate with chloroiodomethane. This approach required the use of the corresponding tetramethylammonium phosphate and a vast excess (>11 equiv) of chloroiodomethane to minimize the formation of tetra-tert-butyl methylene bisphosphate[1].

Uses

Used as an intermediate for laboratory research.

Synthesis

Di-tert-butyl (chloromethyl) phosphate, a key compound in the formation of many phosphon-oxymethyl pro-drugs,  is prepared by reacting chloromethyl chlorosulfate (CMCS) with di-tert-butyl potassium phosphate (DTBPP) .

References

[1] Bin Zheng*. “Development of Efficient Processes for the Preparation of Di-tert-butyl Potassium Phosphate and Di-tert-butyl (Chloromethyl) Phosphate.” Organic Process Research & Development 18 5 (2014): 636–642.

Di-tert-butyl Chloromethyl Phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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Di-tert-butyl Chloromethyl Phosphate Suppliers

Canada 2 China 158 Europe 1 India 14 Japan 1 United Kingdom 2 United States 9 Global 187
BTC pharm India
Tel
+918790379245
Email
banny.janga@btcpharm.com
Country
India
ProdList
1262
Advantage
58
TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
Biokemix
Tel
--
Fax
--
Email
biokemix@yes-boss.com
Country
India
ProdList
486
Advantage
50
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View Lastest Price from Di-tert-butyl Chloromethyl Phosphate manufacturers

Wuhan Konberd Biotech Co., Ltd
Product
Di-tert-butyl Chloromethyl Phosphate 229625-50-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
95+%
Supply Ability
100
Release date
2023-03-07
Hebei Chuanghai Biotechnology Co,.LTD
Product
Di-Tert-Butyl Chloromethyl Phosphate 229625-50-7
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-23
Hebei Mojin Biotechnology Co., Ltd
Product
Di-tert-butyl Chloromethyl Phosphate 229625-50-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2024-09-26

229625-50-7, Di-tert-butyl Chloromethyl PhosphateRelated Search:

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