Di-tert-butyl Chloromethyl Phosphate

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Di-tert-butyl Chloromethyl Phosphate

Product Name: Di-tert-butyl Chloromethyl Phosphate
CAS No.: 229625-50-7
Chemical Name: Di-tert-butyl Chloromethyl Phosphate
Synonyms: Di-tert-butyl Chloromethyl Phosphate;Phosphoric acid di-tert-butyl chloromethyl ester;Fostemsavir-SM;Foscarbidopa Impurity 20;Di-t-butyl chloromethyl phosphate;ditetrabutyl chloromethyl phosphate;Chloromethyl di-tert-butyl phosphate;PHOSPHORIC ACID DERIVATIVE229625-50-7;Di-tert-butyl chloromethyl phosphate 95%;Di tertiary butyl chloromethyl phosphite
CBNumber: CB02515861
Molecular Formula: C9H20ClO4P
Formula Weight: 258.68
MOL File: 229625-50-7.mol

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Di-tert-butyl Chloromethyl Phosphate Property

Boiling point:: 272.9±23.0 °C(Predicted)
Density: 1.115±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: Benzene (Slightly), Methanol (Slightly)
form: clear liquid
color: Colorless to Light yellow
Stability:: Moisture Sensitive
InChI: InChI=1S/C9H20ClO4P/c1-8(2,3)13-15(11,12-7-10)14-9(4,5)6/h7H2,1-6H3
InChIKey: LNJAJHJFSKUCIR-UHFFFAOYSA-N
SMILES: P(OC(C)(C)C)(OC(C)(C)C)(OCCl)=O
CAS DataBase Reference: 229625-50-7

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36/37
HS Code: 29199000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D428028
Product name: Di-tert-butylChloromethylPhosphate(stabilizedwithK2CO3)
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD137343
Product name: Di-tert-butyl chloromethyl phosphate
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 092558
Product name: Di-tert-butyl (chloromethyl) phosphate (stabilized with potassium carbonate)
Purity: 95+%
Packaging: 1g
Price: $87
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD137343
Product name: Di-tert-butyl chloromethyl phosphate
Packaging: 1g
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD137343
Product name: Di-tert-butyl chloromethyl phosphate
Packaging: 2g
Price: $160
Updated: 2021/12/16

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Di-tert-butyl Chloromethyl Phosphate Chemical Properties,Usage,Production

Description

Di-tert-butyl (chloromethyl) phosphate has become one of the most common reagents to prepare phosphon-oxymethyl pro-drugs, generally by direct alkylation of hydroxyl or amino groups. Its synthesis was first reported in 1999 via a reaction of di-tert-butyl tetramethylammonium phosphate with chloroiodomethane. This approach required the use of the corresponding tetramethylammonium phosphate and a vast excess (>11 equiv) of chloroiodomethane to minimize the formation of tetra-tert-butyl methylene bisphosphate[1].

Uses

Used as an intermediate for laboratory research.

Synthesis

Di-tert-butyl (chloromethyl) phosphate, a key compound in the formation of many phosphon-oxymethyl pro-drugs, is prepared by reacting chloromethyl chlorosulfate (CMCS) with di-tert-butyl potassium phosphate (DTBPP) .

References

[1] Bin Zheng*. “Development of Efficient Processes for the Preparation of Di-tert-butyl Potassium Phosphate and Di-tert-butyl (Chloromethyl) Phosphate.” Organic Process Research & Development 18 5 (2014): 636–642.

Di-tert-butyl Chloromethyl Phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Di-tert-butyl Chloromethyl Phosphate manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: Di-tert-butyl Chloromethyl Phosphate 229625-50-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2024-09-26

Wuhan Konberd Biotech Co., Ltd

Product: Di-tert-butyl Chloromethyl Phosphate 229625-50-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 95+%
Supply Ability: 100
Release date: 2023-03-07

PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD

Product: Di-tert-butyl Chloromethyl Phosphate 229625-50-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 MT
Release date: 2024-05-13

229625-50-7, Di-tert-butyl Chloromethyl PhosphateRelated Search:

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229625-50-7

C9H20ClO4P

intermediates

SiChem