MC1568

Product Name: MC1568
CAS No.: 852475-26-4
Chemical Name: MC1568
Synonyms: MC1568;CS-349;CS-2095;MC1568 ，S1484;MC 1568, >=98%;MC 1568;MC-1568;MC1568 USP/EP/BP;MC1568, 10 mM in DMSO;MC1568;MC 1568;MC-1568;3-[4-[3-(3-Fluorophenyl)-3-oxo-1-propenyl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide
CBNumber: CB02517946
Molecular Formula: C17H15FN2O3
Formula Weight: 314.31
MOL File: 852475-26-4.mol

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MC1568 Property

Melting point:: 212-215 °C(Solv: acetonitrile (75-05-8); methanol (67-56-1))
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥10mg/mL
pka: 8.91±0.23(Predicted)
form: powder
color: orange
InChIKey: QRDAPCMJAOQZSU-KQQUZDAGSA-N
CAS DataBase Reference: 852475-26-4

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M1824
Product name: MC1568
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $217
Updated: 2025/07/31

Sigma-Aldrich

Product number: M1824
Product name: MC1568
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $865
Updated: 2025/07/31

Cayman Chemical

Product number: 16265
Product name: MC 1568
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16265
Product name: MC 1568
Purity: ≥95%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 16265
Product name: MC 1568
Purity: ≥95%
Packaging: 10mg
Price: $139
Updated: 2024/03/01

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MC1568 Chemical Properties,Usage,Production

Description

While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling. Class IIa HDACs, which includes HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology. MC 1568 is a selective inhibitor of class IIa HDACs, with greater than 170-fold selectivity over class I HDACs, including HDAC1. It has been used in cells (1-10 μM) and in mice to elucidate the roles of class IIa HDACs in cell proliferation and differentiation, apoptosis, myogenesis, adipogenesis, and fibrosis.

Uses

While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling. Class IIa HDACs, which includes HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology. MC 1568 is a selective inhibitor of class IIa HDACs, with greater than 170-fold selectivity over class I HDACs, including HDAC1. It has been used in cells (1-10 μM) and in mice to elucidate the roles of class IIa HDACs in cell proliferation and differentiation, apoptosis, myogenesis, adipogenesis, and fibrosis.[Cayman Chemical]

Uses

A selective class II (IIa) histone deacetylase (HDAC II) inhibitor. It exhibits tissue-selective inhibition between members of class II acetylases in vivo, particularly in skeletal muscle and the heart. It arrests myogenesis through the stabilization of myocyte enhancer factor 2D (MEF2D)-HDAC3/4 complex.

Definition

ChEBI: 3-[4-[3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methyl-2-pyrrolyl]-N-hydroxy-2-propenamide is a carbonyl compound.

Biochem/physiol Actions

MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor.

storage

+4°C

References

[1] ANTONELLO MAI. Class II (IIa)-Selective Histone Deacetylase Inhibitors. 1. Synthesis and Biological Evaluation of Novel (Aryloxopropenyl)pyrrolyl Hydroxyamides[J]. Journal of Medicinal Chemistry, 2005, 48 9: 3344-3353. DOI: 10.1021/jm049002a
[2] ANTONELLO MAI. Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia.[J]. Molecular Pharmacology, 2007, 72 5: 1111-1123. DOI: 10.1124/mol.107.036772
[3] ANGELA NEBBIOSO. Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes.[J]. EMBO Reports, 2009, 10 7: 776-782. DOI: 10.1038/embor.2009.88
[4] VANESSA DUONG. Specific activity of class II histone deacetylases in human breast cancer cells.[J]. Molecular Cancer Research, 2008, 6 12: 1908-1919. DOI: 10.1158/1541-7786.mcr-08-0299
[5] ANGELA NEBBIOSO. HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation.[J]. Journal of molecular endocrinology, 2010, 45 4: 219-228. DOI: 10.1677/jme-10-0043
[6] GUAN WANG. Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer.[J]. PLoS ONE, 2012: e52095. DOI: 10.1371/journal.pone.0052095
[7] INGE MANNAERTS. Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29.[J]. PLoS ONE, 2013: e55786. DOI: 10.1371/journal.pone.0055786
[8] FRANCESCO SPALLOTTA. Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia.[J]. The Journal of Biological Chemistry, 2013, 288 32: 22915-22929. DOI: 10.1074/jbc.m113.484337

MC1568 Preparation Products And Raw materials

Raw materials

Preparation Products

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MC1568 Suppliers

Canada 1 China 110 China Hong Kong 1 India 2 United Kingdom 2 United States 20 Global 136

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

ChemCell Biomedicine Co.,Ltd.

Tel: 020-13556033878 2965585218 13556033878
Fax: 0086-0757-85406358
Email: chemcell@hotmail.com
Country: China
ProdList: 369
Advantage: 52

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
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NCE Biomedical Co.,Ltd.

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Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
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View Lastest Price from MC1568 manufacturers

Career Henan Chemical Co

Product: MC1568 852475-26-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

852475-26-4, MC1568Related Search:

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3-[4-(3-(3-Fluorophenyl)-3-oxo-1-propen-1-yl)-1-Methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenaMide

(E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide

3-[4-[3-(3-Fluorophenyl)-3-oxo-1-propenyl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide MC1568

MC 1568 3-[4-[3-(3-Fluorophenyl)-3-oxo-1-propenyl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide

(E)-3-(5-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide

3-[5-(3-(3-Fluorophenyl)-3-oxopropen-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide

MC 1568, >=98%

(E)-3-(5-((E)-3-(3-fluorophenyl)-3-oxoprop-1-en-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide

(E)-3-(4-((E)-3-(3-Fluorophenyl)-3-oxoprop-1-en-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacryla

MC1568

3-[4-[3-(3-Fluorophenyl)-3-oxo-1-propenyl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide

MC 1568;MC-1568

CS-2095

CS-349

MC1568;MC 1568;MC-1568

(E)-3-[4-[(E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methylpyrrol-2-yl]-N-hydroxyprop-2-enamide

2-Propenamide, 3-[5-[(1E)-3-(3-fluorophenyl)-3-oxo-1-propen-1-yl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-, (2E)-

MC1568 USP/EP/BP

MC1568, 10 mM in DMSO

MC1568 ，S1484

852475-26-4

Inhibitor

Aromatics

API

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Selective inhibitor of class II (IIa) histone deacetylase (HDAC).