MC1568

Product Name: MC1568
CAS No.: 852475-26-4
Chemical Name: MC1568
Synonyms: MC1568;CS-349;CS-2095;MC 1568, >=98%;MC 1568;MC-1568;MC1568 USP/EP/BP;MC1568;MC 1568;MC-1568;3-[4-[3-(3-Fluorophenyl)-3-oxo-1-propenyl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide;3-[5-(3-(3-Fluorophenyl)-3-oxopropen-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide;(E)-3-(4-((E)-3-(3-Fluorophenyl)-3-oxoprop-1-en-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacryla
CBNumber: CB02517946
Molecular Formula: C17H15FN2O3
Formula Weight: 314.31
MOL File: 852475-26-4.mol

More

Less

MC1568 Property

Melting point:: 212-215 °C(Solv: acetonitrile (75-05-8); methanol (67-56-1))
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥10mg/mL
pka: 8.91±0.23(Predicted)
form: powder
color: orange
InChIKey: QRDAPCMJAOQZSU-KQQUZDAGSA-N
CAS DataBase Reference: 852475-26-4

More

Less

Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M1824
Product name: MC1568
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $211
Updated: 2024/03/01

Sigma-Aldrich

Product number: M1824
Product name: MC1568
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $841
Updated: 2024/03/01

Cayman Chemical

Product number: 16265
Product name: MC 1568
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16265
Product name: MC 1568
Purity: ≥95%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 16265
Product name: MC 1568
Purity: ≥95%
Packaging: 10mg
Price: $139
Updated: 2024/03/01

More

Less

MC1568 Chemical Properties,Usage,Production

Description

While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling. Class IIa HDACs, which includes HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology. MC 1568 is a selective inhibitor of class IIa HDACs, with greater than 170-fold selectivity over class I HDACs, including HDAC1. It has been used in cells (1-10 μM) and in mice to elucidate the roles of class IIa HDACs in cell proliferation and differentiation, apoptosis, myogenesis, adipogenesis, and fibrosis.

Uses

While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling. Class IIa HDACs, which includes HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology. MC 1568 is a selective inhibitor of class IIa HDACs, with greater than 170-fold selectivity over class I HDACs, including HDAC1. It has been used in cells (1-10 μM) and in mice to elucidate the roles of class IIa HDACs in cell proliferation and differentiation, apoptosis, myogenesis, adipogenesis, and fibrosis.[Cayman Chemical]

Uses

A selective class II (IIa) histone deacetylase (HDAC II) inhibitor. It exhibits tissue-selective inhibition between members of class II acetylases in vivo, particularly in skeletal muscle and the heart. It arrests myogenesis through the stabilization of myocyte enhancer factor 2D (MEF2D)-HDAC3/4 complex.

Definition

ChEBI: 3-[4-[3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methyl-2-pyrrolyl]-N-hydroxy-2-propenamide is a carbonyl compound.

Biochem/physiol Actions

MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor.

storage

+4°C

MC1568 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

MC1568 Suppliers

Canada 1 China 87 China Hong Kong 1 India 2 United Kingdom 2 United States 20 Global 113

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15421
Advantage: 60

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5700
Advantage: 66

ChemCell Biomedicine Co.,Ltd.

Tel: 020-13556033878 2965585218 13556033878
Fax: 0086-0757-85406358
Email: chemcell@hotmail.com
Country: China
ProdList: 369
Advantage: 52

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9872
Advantage: 52

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1494
Advantage: 55

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9901
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

More

Less

View Lastest Price from MC1568 manufacturers

Career Henan Chemical Co

Product: MC1568 852475-26-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

852475-26-4, MC1568Related Search:

Tacedinaline Mocetinostat (MGCD0103) Vorinostat Belinostat (PXD101) Entinostat Givinostat (ITF2357)

3-[4-(3-(3-Fluorophenyl)-3-oxo-1-propen-1-yl)-1-Methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenaMide

(E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide

3-[4-[3-(3-Fluorophenyl)-3-oxo-1-propenyl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide MC1568

MC 1568 3-[4-[3-(3-Fluorophenyl)-3-oxo-1-propenyl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide

(E)-3-(5-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide

3-[5-(3-(3-Fluorophenyl)-3-oxopropen-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide

MC 1568, >=98%

(E)-3-(5-((E)-3-(3-fluorophenyl)-3-oxoprop-1-en-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide

(E)-3-(4-((E)-3-(3-Fluorophenyl)-3-oxoprop-1-en-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacryla

MC1568

3-[4-[3-(3-Fluorophenyl)-3-oxo-1-propenyl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide

MC 1568;MC-1568

CS-2095

CS-349

MC1568;MC 1568;MC-1568

(E)-3-[4-[(E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methylpyrrol-2-yl]-N-hydroxyprop-2-enamide

2-Propenamide, 3-[5-[(1E)-3-(3-fluorophenyl)-3-oxo-1-propen-1-yl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-, (2E)-

MC1568 USP/EP/BP

852475-26-4

Inhibitor

Aromatics

API

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Selective inhibitor of class II (IIa) histone deacetylase (HDAC).