ChemicalBook > CAS DataBase List > N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
- Product Name
- N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
- CAS No.
- 444731-75-3
- Chemical Name
- N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
- Synonyms
- BNKY007-PZ02;Pazopanib Impurity 22;Pazopanib Impurity 34;Pazopanib intermediate;Pazopanib ( PAZ ) N - Methyl compound;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethylindazol-6-amine;N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-2H-indazol-6-aMine;N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine;N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-1H-indazol-6-amine;2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-N,2,3-triMethyl-
- CBNumber
- CB02526159
- Molecular Formula
- C14H14ClN5
- Formula Weight
- 287.75
- MOL File
- 444731-75-3.mol
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N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Property
- Melting point:
- 167-173℃
- Boiling point:
- 524.4±35.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
- pka
- 2.82±0.30(Predicted)
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 444731-75-3
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Alfa Aesar
- Product number
- H33611
- Product name
- 6-[N-(2-chloro-4-pyrimidinyl)methylamino]-2,3-dimethyl-2H-indazole, 96%
- Packaging
- 500mg
- Price
- $102
- Updated
- 2023/06/20
TRC
- Product number
- C380090
- Product name
- N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine
- Packaging
- 1g
- Price
- $155
- Updated
- 2021/12/16
TRC
- Product number
- C380090
- Product name
- N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine
- Packaging
- 10g
- Price
- $1210
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 139007
- Product name
- N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine
- Purity
- 95%+
- Packaging
- 1g
- Price
- $1554
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 139007
- Product name
- N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine
- Purity
- 95%+
- Packaging
- 2.500g
- Price
- $3386
- Updated
- 2021/12/16
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N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Chemical Properties,Usage,Production
Chemical Properties
Light Beige to Beige Solid
Uses
N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
Synthesis
A flask was charged with N,2,3-trimethyl-2H-indazol-6-amine (1 eq.), 2,4-dichloropyrimidine (1.5 eq.), sodium bicarbonate (2 eq.) and N, N-dimethylformamide. The reaction mixture was stirred at 85 °C until completion of the reaction. Then, water was added and stirred for 3 h. Product crystals were collected by filtration, washed with water, and then dried to get N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine as off-white/beige powder (Yield: 97%).
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Preparation Products And Raw materials
Raw materials
Preparation Products
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N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58
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View Lastest Price from N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine manufacturers
Hebei Zhuanglai Chemical Trading Co Ltd
- Product
- N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 444731-75-3
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-11-13
Nanjing Fred Technology Co., Ltd
- Product
- N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine 444731-75-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- ton
- Release date
- 2023-11-15
Hebei Ganmiao New material Technology Co., LTD
- Product
- N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 444731-75-3
- Price
- US $10.00-7.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 20ton
- Release date
- 2024-06-06
444731-75-3, N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMineRelated Search:
5-BROMO-3-METHYLINDOLE
2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI)
1,3-DiMethyl-6-aMino-1H-indazole
4(1H)-Pyrimidinone, 2-chloro- (9CI)
5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
Pazopanib-d6
2,3-dimethyl-2H-indazol-6-amine hydrochloride
Pazopanib Impurity 9
Pazopanib
Pazopanib Related Compound 2
1,3-Dimethyl-6-nitro-1H-indazole
Pazopanib Related Compound 3
3-Methyl-6-nitro-2H-indazole
4-Acetoxy-3-acetoxymethylacetophenone
(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
(4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid
Pazopanib Impurity 10