Benzoic acid,5-broMo-2-(trifluoroMethyl)-,Methyl ester
- Product Name
- Benzoic acid,5-broMo-2-(trifluoroMethyl)-,Methyl ester
- CAS No.
- 842136-32-7
- Chemical Name
- Benzoic acid,5-broMo-2-(trifluoroMethyl)-,Methyl ester
- Synonyms
- Methyl 5-bromo-2-(trifluoromethyl);Methyl 5-broMo-2-(trifluoroMethyl)benzoate;Benzoic acid,5-broMo-2-(trifluoroMethyl)-,Methyl ester
- CBNumber
- CB02550040
- Molecular Formula
- C9H6BrF3O2
- Formula Weight
- 283.04
- MOL File
- 842136-32-7.mol
Benzoic acid,5-broMo-2-(trifluoroMethyl)-,Methyl ester Property
- Boiling point:
- 280.9±40.0 °C(Predicted)
- Density
- 1.598±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- liquid
- color
- Clear, faint to light yellow
Safety
- HS Code
- 2916310090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M296553
- Product name
- Methyl5-Bromo-2-(trifluoromethyl)benzoate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- HCH0369505
- Product name
- METHYL-5-BROMO-2-(TRIFLUOROMETHYL)BENZOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.8
- Updated
- 2021/12/16
- Product number
- 2940AC
- Product name
- Methyl5-bromo-2-(trifluoromethyl)benzoate
- Packaging
- 5g
- Price
- $517
- Updated
- 2021/12/16
- Product number
- PC500761
- Product name
- Methyl5-bromo-2-(trifluoromethyl)benzoate
- Packaging
- 5g
- Price
- $1008
- Updated
- 2021/12/16
- Product number
- 2823-B-03
- Product name
- Methyl 5-bromo-2-(trifluoromethyl)benzoate
- Packaging
- 5G
- Price
- $1112
- Updated
- 2021/12/16
Benzoic acid,5-broMo-2-(trifluoroMethyl)-,Methyl ester Chemical Properties,Usage,Production
Synthesis
680-15-9
181765-86-6
842136-32-7
A. Synthesis of methyl 5-bromo-2-(trifluoromethyl)benzoate. Methyl 5-bromo-2-iodobenzoate (4.65 g, 13.64 mmol) and methyl fluorosulfonyl difluoroacetate (2.6 mL, 20.44 mmol) were dissolved in N-methyl-2-pyrrolidone (10 mL) under nitrogen protection. Copper (I) bromide (235 mg, 1.638 mmol) was subsequently added. The reaction mixture was transferred to a sealed tube and the reaction was stirred at 120 °C for 15 hours. After completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate and washed with saturated aqueous sodium chloride solution. The aqueous phase was back-extracted with ethyl acetate (3 x 25 mL), the organic phases were combined and dried over anhydrous magnesium sulfate. After filtration, the solvent was removed by concentration under reduced pressure. The residue was purified by silica gel column chromatography with hexane solution of 1-5% ethyl acetate as eluent to afford methyl 5-bromo-2-trifluoromethylbenzoate as a colorless oil (2.9 g, 10.25 mmol, 75% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.08 (s, 1H), 8.01 (d, J = 8.20 Hz, 1H), 7.83 (d, J = 8.20 Hz, 1H), 3.90 (s, 3H).
References
[1] Patent: WO2009/89042, 2009, A1. Location in patent: Page/Page column 101
Benzoic acid,5-broMo-2-(trifluoroMethyl)-,Methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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