2-Bromo-5-chloro-3-fluoropyridine
- Product Name
- 2-Bromo-5-chloro-3-fluoropyridine
- CAS No.
- 514797-97-8
- Chemical Name
- 2-Bromo-5-chloro-3-fluoropyridine
- Synonyms
- 2-Bromo-3-fluoro-5-chloropyridine;2-Bromo-5-chloro-3-fluoropyridine;Pyridine, 2-bromo-5-chloro-3-fluoro-;2-Bromo-5-chloro-3-fluoropyridine ISO 9001：2015 REACH
- CBNumber
- CB41459618
- Molecular Formula
- C5H2BrClFN
- Formula Weight
- 210.43
- MOL File
- 514797-97-8.mol
2-Bromo-5-chloro-3-fluoropyridine Property
- Boiling point:
- 190.8±35.0 °C(Predicted)
- Density
- 1.829±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.92±0.20(Predicted)
- form
- solid
- color
- White to off-white
- InChI
- InChI=1S/C5H2BrClFN/c6-5-4(8)1-3(7)2-9-5/h1-2H
- InChIKey
- PYDGFYYLQFJQBZ-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC=C(Cl)C=C1F
Safety
- RIDADR
- UN2811
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B683193
- Product name
- 2-Bromo-5-chloro-3-fluoropyridine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB54502
- Product name
- 2-Bromo-3-fluoro-5-chloropyridine
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- Y9286
- Product name
- 2-Bromo-5-chloro-3-fluoropyridine
- Packaging
- 10g
- Price
- $127
- Updated
- 2021/12/16
- Product number
- 070186
- Product name
- 2-Bromo-5-chloro-3-fluoropyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $135
- Updated
- 2021/12/16
- Product number
- HCH0320735
- Product name
- 2-BROMO-5-CHLORO-3-FLUOROPYRIDINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $135.45
- Updated
- 2021/12/16
2-Bromo-5-chloro-3-fluoropyridine Chemical Properties,Usage,Production
Synthesis
246847-98-3
514797-97-8
Step 1: 2-Amino-3-fluoro-5-chloropyridine (5.0 g, 34 mmol) was slowly added to 48% hydrobromic acid (HBr) solution (20 mL) at 0°C with stirring. Bromine (Br2, 5.24 mL, 102.3 mmol) was then added dropwise to the resulting mixture over 20 min at 0 °C. The reaction mixture was cooled to -10°C. A solution of sodium nitrite (NaNO2, 5.88 g, 85.3 mmol) in water (20 mL) was slowly added to the mixture over a period of 1.5 h and the mixture continued to be stirred for 30 min. Subsequently, a solution of sodium hydroxide (NaOH, 12 g, 306 mmol) in water (20 mL) was added over 30 minutes and the mixture was gradually warmed to room temperature. After completion of the reaction, the mixture was extracted with ether (3 x 100 mL). The combined organic phases were washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to give the title compound 2-bromo-5-chloro-3-fluoropyridine as a pale yellow solid (6.43 g, 90% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.23 (d, J = 2.1 Hz, 1H), 7.48 (dd, J = 7.1,2.1 Hz, 1H).
References
[1] Patent: WO2015/187845, 2015, A1. Location in patent: Paragraph 0218
[2] Patent: WO2016/44323, 2016, A1. Location in patent: Paragraph 0323
2-Bromo-5-chloro-3-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-5-chloro-3-fluoropyridine manufacturers
- Product
- 2-Bromo-5-chloro-3-fluoropyridine 514797-97-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-03
- Product
- 2-Bromo-5-chloro-3-fluoropyridine 514797-97-8
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99
- Supply Ability
- 100kg
- Release date
- 2020-01-07