ChemicalBook > CAS DataBase List > 2-Bromo-5-chloro-3-fluoropyridine

2-Bromo-5-chloro-3-fluoropyridine

Product Name: 2-Bromo-5-chloro-3-fluoropyridine
CAS No.: 514797-97-8
Chemical Name: 2-Bromo-5-chloro-3-fluoropyridine
Synonyms: 2-Bromo-3-fluoro-5-chloropyridine;2-Bromo-5-chloro-3-fluoropyridine;Pyridine, 2-bromo-5-chloro-3-fluoro-;2-Bromo-5-chloro-3-fluoropyridine ISO 9001：2015 REACH
CBNumber: CB41459618
Molecular Formula: C5H2BrClFN
Formula Weight: 210.43
MOL File: 514797-97-8.mol

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2-Bromo-5-chloro-3-fluoropyridine Property

Boiling point:: 190.8±35.0 °C(Predicted)
Density: 1.829±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.92±0.20(Predicted)
form: solid
color: White to off-white
InChI: InChI=1S/C5H2BrClFN/c6-5-4(8)1-3(7)2-9-5/h1-2H
InChIKey: PYDGFYYLQFJQBZ-UHFFFAOYSA-N
SMILES: C1(Br)=NC=C(Cl)C=C1F

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Safety

RIDADR: UN2811
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B683193
Product name: 2-Bromo-5-chloro-3-fluoropyridine
Packaging: 1g
Price: $75
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B12451
Product name: 2-Bromo-5-chloro-3-fluoropyridine
Purity: 95%
Packaging: 1g
Price: $4
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B12451
Product name: 2-Bromo-5-chloro-3-fluoropyridine
Purity: 95%
Packaging: 5g
Price: $15
Updated: 2021/12/16

Apolloscientific

Product number: PC5924
Product name: 2-Bromo-5-chloro-3-fluoropyridine
Packaging: 1g
Price: $43
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-F-03
Product name: 2-Bromo-5-chloro-3-fluoropyridine
Packaging: 1g
Price: $47
Updated: 2021/12/16

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2-Bromo-5-chloro-3-fluoropyridine Chemical Properties,Usage,Production

Synthesis

246847-98-3

514797-97-8

Step 1: 2-Amino-3-fluoro-5-chloropyridine (5.0 g, 34 mmol) was slowly added to 48% hydrobromic acid (HBr) solution (20 mL) at 0°C with stirring. Bromine (Br2, 5.24 mL, 102.3 mmol) was then added dropwise to the resulting mixture over 20 min at 0 °C. The reaction mixture was cooled to -10°C. A solution of sodium nitrite (NaNO2, 5.88 g, 85.3 mmol) in water (20 mL) was slowly added to the mixture over a period of 1.5 h and the mixture continued to be stirred for 30 min. Subsequently, a solution of sodium hydroxide (NaOH, 12 g, 306 mmol) in water (20 mL) was added over 30 minutes and the mixture was gradually warmed to room temperature. After completion of the reaction, the mixture was extracted with ether (3 x 100 mL). The combined organic phases were washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to give the title compound 2-bromo-5-chloro-3-fluoropyridine as a pale yellow solid (6.43 g, 90% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.23 (d, J = 2.1 Hz, 1H), 7.48 (dd, J = 7.1,2.1 Hz, 1H).

References

[1] Patent: WO2015/187845, 2015, A1. Location in patent: Paragraph 0218
[2] Patent: WO2016/44323, 2016, A1. Location in patent: Paragraph 0323

2-Bromo-5-chloro-3-fluoropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Bromo-5-chloro-3-fluoropyridine manufacturers

Dideu Industries Group Limited

Product: 2-Bromo-5-chloro-3-fluoropyridine 514797-97-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-03

Career Henan Chemical Co

Product: 2-Bromo-5-chloro-3-fluoropyridine 514797-97-8
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 100kg
Release date: 2020-01-07

514797-97-8, 2-Bromo-5-chloro-3-fluoropyridineRelated Search:

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2-Bromo-5-chloro-3-fluoropyridine ISO 9001：2015 REACH

514797-97-8

Halides

Heterocycles