(+)-Fluprostenol
- Product Name
- (+)-Fluprostenol
- CAS No.
- 54276-17-4
- Chemical Name
- (+)-Fluprostenol
- Synonyms
- (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoroMethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid;AL 5848;Travoprost 2;Travoprost Acid;(+)-Fluprostenol;Travoprost Acid-d4;[3H]-Travoprost acid;Travoprost free acid;Ttravoprost free acid;Travoprost impurity E
- CBNumber
- CB02551360
- Molecular Formula
- C23H29F3O6
- Formula Weight
- 458.47
- MOL File
- 54276-17-4.mol
(+)-Fluprostenol Property
- Boiling point:
- 608.0±55.0 °C(Predicted)
- Density
- 1.335±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated), Dichloromethane, Acetonitrile
- form
- Solid
- pka
- 4.76±0.10(Predicted)
- color
- Colourless to Pale Yellow Oil
Safety
- HS Code
- 2937500000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H370Causes damage to organs
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P307+P311IF exposed: call a POISON CENTER or doctor/physician.
P314Get medical advice/attention if you feel unwell.
P321Specific treatment (see … on this label).
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 16768
- Product name
- Fluprostenol
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $64
- Updated
- 2024/03/01
- Product number
- 16768
- Product name
- Fluprostenol
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $280
- Updated
- 2024/03/01
- Product number
- 16768
- Product name
- Fluprostenol
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $497
- Updated
- 2024/03/01
- Product number
- 16768
- Product name
- Fluprostenol
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $1084
- Updated
- 2024/03/01
- Product number
- T715620
- Product name
- TravoprostAcid
- Packaging
- 25mg
- Price
- $895
- Updated
- 2021/12/16
(+)-Fluprostenol Chemical Properties,Usage,Production
Uses
A metabolically stable analog of Prostaglandin F2α (P838625) with potent FP receptor agonist activity. An impurity of Travoprost (T715600).
Uses
Fluprostenol is a metabolically stable analog of PGF2α with potent FP receptor agonist activity. Fluprostenol is the optically active enantiomer of fluprostenol and would be expected to have twice the potency as the racemic mixture. Fluprostenol inhibits PGF2α binding to human and rat FP receptors with IC50 values of 3.5 and 7.5 nM, respectively. It is a much more potent luteolytic agent than PGF2α in rats with a minimum fully effective dose of 270 μg/kg to terminate pregnancy. It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3-10 x 10?11 M.[Cayman Chemical]
Definition
ChEBI: Fluprostenol is an organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea. It has a role as an antiglaucoma drug, an antihypertensive agent, a prostaglandin receptor agonist, a female contraceptive drug and an abortifacient. It is a prostaglandins Falpha, a hydroxy monocarboxylic acid and a member of (trifluoromethyl)benzenes.
(+)-Fluprostenol Preparation Products And Raw materials
Raw materials
Preparation Products
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