ChemicalBook > CAS DataBase List > (+)-Fluprostenol

(+)-Fluprostenol

Product Name
(+)-Fluprostenol
CAS No.
54276-17-4
Chemical Name
(+)-Fluprostenol
Synonyms
(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoroMethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid;AL 5848;Travoprost 2;Travoprost Acid;(+)-Fluprostenol;Travoprost Acid-d4;[3H]-Travoprost acid;Travoprost free acid;Ttravoprost free acid;Travoprost impurity E
CBNumber
CB02551360
Molecular Formula
C23H29F3O6
Formula Weight
458.47
MOL File
54276-17-4.mol
More
Less

(+)-Fluprostenol Property

Boiling point:
608.0±55.0 °C(Predicted)
Density 
1.335±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated), Dichloromethane, Acetonitrile
form 
Solid
pka
4.76±0.10(Predicted)
color 
Colourless to Pale Yellow Oil
More
Less

Safety

HS Code 
2937500000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H370Causes damage to organs

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
16768
Product name
Fluprostenol
Purity
≥95%
Packaging
1mg
Price
$64
Updated
2024/03/01
Cayman Chemical
Product number
16768
Product name
Fluprostenol
Purity
≥95%
Packaging
5mg
Price
$280
Updated
2024/03/01
Cayman Chemical
Product number
16768
Product name
Fluprostenol
Purity
≥95%
Packaging
10mg
Price
$497
Updated
2024/03/01
Cayman Chemical
Product number
16768
Product name
Fluprostenol
Purity
≥95%
Packaging
25mg
Price
$1084
Updated
2024/03/01
TRC
Product number
T715620
Product name
TravoprostAcid
Packaging
25mg
Price
$895
Updated
2021/12/16
More
Less

(+)-Fluprostenol Chemical Properties,Usage,Production

Uses

A metabolically stable analog of Prostaglandin F2α (P838625) with potent FP receptor agonist activity. An impurity of Travoprost (T715600).

Uses

Fluprostenol is a metabolically stable analog of PGF2α with potent FP receptor agonist activity. Fluprostenol is the optically active enantiomer of fluprostenol and would be expected to have twice the potency as the racemic mixture. Fluprostenol inhibits PGF2α binding to human and rat FP receptors with IC50 values of 3.5 and 7.5 nM, respectively. It is a much more potent luteolytic agent than PGF2α in rats with a minimum fully effective dose of 270 μg/kg to terminate pregnancy. It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3-10 x 10?11 M.[Cayman Chemical]

Definition

ChEBI: Fluprostenol is an organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea. It has a role as an antiglaucoma drug, an antihypertensive agent, a prostaglandin receptor agonist, a female contraceptive drug and an abortifacient. It is a prostaglandins Falpha, a hydroxy monocarboxylic acid and a member of (trifluoromethyl)benzenes.

(+)-Fluprostenol Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(+)-Fluprostenol Suppliers

Scinova Biotech(Guangzhou) Co., Ltd.
Tel
13268215580
Email
scinova_sales@163.com
Country
China
ProdList
7023
Advantage
58
Shandong Boluoda Biological Technology Co., Ltd.
Tel
0531-58190570 15863796298
Email
2310993908@qq.com
Country
China
ProdList
1296
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
Cato Research Chemicals Inc.
Tel
020-81960175
Fax
+1-541-2553641
Email
min.he@cato-chem.com
Country
China
ProdList
1955
Advantage
55
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60

54276-17-4, (+)-FluprostenolRelated Search:


  • (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoroMethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid
  • [1R-[1α(Z),2β(1E,3R*),3α,5α]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoroMethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid
  • 16-(M-TrifluoroMethylphenoxy)-17,18,19,20-tetranorprostaglandin F2α
  • AL 5848
  • Travoprost Acid
  • Ttravoprost free acid
  • Travoprost Acid-d4
  • [3H]-Travoprost acid
  • Travoprost Impurity 12(Fluprostenol)
  • (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic acid
  • Travoprost Acid/Travoprost USP Related Compound A/(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid
  • Fluprostenol Travoprost acid
  • 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-, (5Z)-
  • Travoprost free acid
  • (Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoic acid
  • Travoprost Related Compound A (1673012)Q: What is Travoprost Related Compound A (1673012) Q: What is the CAS Number of Travoprost Related Compound A (1673012)
  • Travoprost impurity E
  • Travoprost 2
  • PTGER2,Oviductal glycoprotein 1,(+) Fluprostenol,inhibit,(+)Fluprostenol,OVGP1,Inhibitor,(+)-Fluprostenol
  • (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E,3R)-3-hydroxy- 4-[3-(trifluoromethyl) phenoxy] but-1-enyl] cyclopentyl]hept-5-enoic acid
  • (+)-Fluprostenol
  • 54276-17-4
  • API
  • Agonists
  • Chiral Reagents
  • Impurities
  • Intermediates & Fine Chemicals
  • Pharmaceuticals