9-keto Fluprostenol isopropyl ester
- Product Name
- 9-keto Fluprostenol isopropyl ester
- CAS No.
- 1219032-18-4
- Chemical Name
- 9-keto Fluprostenol isopropyl ester
- Synonyms
- Travoprost 12;9-Keto Travoprost;Travoprost Impurity 21;Travoprost Impurity 35;9-KETO FLUPROSTENOL ISOPROPYL ESTER;FLUPROSTENOL PROSTAGLANDIN E2 ISOPROPYL ESTER;Travoprost Impurity 16（9-keto Fluprostenol Isopropyl Ester）;(+)-9-OXO-11ALPHA,15R-DIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC-ACID, ISOPROPYL ESTER;(+)-9-OXO-11ALPHA,15R-DIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC-ACID, ISOPROPYL ESTER;5-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-5-oxocyclopentyl]-, 1-methylethyl ester, (5Z)-
- CBNumber
- CB1143711
- Molecular Formula
- C26H33F3O6
- Formula Weight
- 498.53
- MOL File
- Mol file
9-keto Fluprostenol isopropyl ester Property
- Boiling point:
- 583.6±50.0 °C(Predicted)
- Density
- 1.241±0.06 g/cm3(Predicted)
- solubility
- DMF: 30 mg/ml; DMF:PBS (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 25 mg/ml
- pka
- 13.32±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 16782
- Product name
- 9-keto Fluprostenol isopropyl ester
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $88
- Updated
- 2024/03/01
- Product number
- 16782
- Product name
- 9-keto Fluprostenol isopropyl ester
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $389
- Updated
- 2024/03/01
- Product number
- 16782
- Product name
- 9-keto Fluprostenol isopropyl ester
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $691
- Updated
- 2024/03/01
- Product number
- 1006AH
- Product name
- (+)-9-oxo-11alpha,15R-Dihydroxy-16-(3-(trifluoromethyl)Phenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oicacidisopropylester
- Packaging
- 10mg
- Price
- $866
- Updated
- 2021/12/16
- Product number
- MTB0002293
- Product name
- (+)-9-OXO-11ALPHA,15R-DIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID ISOPROPYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.76
- Updated
- 2021/12/16
9-keto Fluprostenol isopropyl ester Chemical Properties,Usage,Production
Uses
9-Keto Travoprost is an impurity of Travoprost (T715600), a selective FP prostaglandin receptor agonist used to treat glaucoma (1,2).
Uses
Fluprostenol is a well-studied, potent analog of prostaglandin F2α (PGF2α) and acts primarily through the FP receptor. 9-keto Fluprostenol is an analog of PGE2 with structural modifications intended to give it a prolonged half-life and greater potency. 9-keto Fluprostenol isopropyl ester has the potential to act as an EP agonist in prodrug form. However, no studies on the pharmacology of this compound have been published to date. In addition 9-keto fluprostenol isopropyl ester is a potential metabolite of Travoprost, which is the Alcon trade name for fluprostenol isopropyl ester. In monkey cornea, this transformation was observed as a product of NADP+-dependent 15-hydroxyprostaglandin dehydrogenase when the closely related analog Latanoprost was used as a substrate. Certain F-series prostaglandins have been shown to be converted to the corresponding E-series compounds in rabbit liver and human platelet preparations.
9-keto Fluprostenol isopropyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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