6-Bromonaphthalen-2-amine hydrochloride

6-Bromonaphthalen-2-amine hydrochloride Property

storage temp. 

Inert atmosphere,Room Temperature

Appearance

Off-white to gray Solid

InChI

InChI=1S/C10H8BrN.ClH/c11-9-3-1-8-6-10(12)4-2-7(8)5-9;/h1-6H,12H2;1H

InChIKey

PIUVTVGJKFGBJL-UHFFFAOYSA-N

SMILES

C1=C2C(C=C(Br)C=C2)=CC=C1N.[H]Cl

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

6-Bromonaphthalen-2-amine hydrochloride Chemical Properties,Usage,Production

Synthesis

General procedure for the synthesis of 6-bromo-2-naphthalenamine hydrochloride from 6-bromo-2-naphthalenecarboxylic acid: 6-bromo-2-naphthalenecarboxylic acid (80.3 g, 319 mmol), diphenylphosphoryl azide (71 mL, 352 mmol), and triethylamine (50 mL, 358 mmol) were dissolved in tertiary butanol (400 mL), heated to reflux and stirred at this temperature for 15 hours. Upon completion of the reaction, the mixture was cooled to room temperature and poured into saturated aqueous sodium bicarbonate solution (600 mL) with vigorous stirring for 30 minutes. The resulting suspension was filtered, washed with water (200 mL), and dried under vacuum at 65 °C. The mixture was then dried over water. The obtained white solid was suspended in methanol (500 mL), cooled to -78 °C and passed through hydrogen chloride gas to saturation. Subsequently, the reaction mixture was stirred at room temperature for 15 h. The solid was collected by filtration and washed with ice-cold methanol (100 mL) to afford 6-bromo-2-naphthylamine hydrochloride (Int-6a) as an off-white solid (74.8 g, 91% yield), which could be used for the subsequent reaction without further purification. NMR hydrogen spectrum (DMSO-d6) δ: 10.5-10.0 (broad single peak, 3H), 8.23 (single peak, 1H), 7.99 (double peak, J = 9.0 Hz, 1H), 7.92 (double peak, J = 9.0 Hz, 1H), 7.84 (single peak, 1H), 7.68-7.65 (multiple peaks, 1H), 7.56-7.51 (multiple peaks). 1H). Low resolution mass spectrum: (M + 2H)+ = 223.

References

[1] Patent: WO2011/87740, 2011, A1. Location in patent: Page/Page column 74
[2] Patent: WO2011/66241, 2011, A1. Location in patent: Page/Page column 108
[3] Patent: EP2545060, 2015, B1. Location in patent: Paragraph 0328; 0329