ChemicalBook > CAS DataBase List > 6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one

6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one

Product Name
6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one
CAS No.
98453-60-2
Chemical Name
6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one
Synonyms
6-Bromo-4,4-dimethyl-2,3-dihydronaphthalen-1-one;6-Bromo-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one;6-Bromo-3,4-dihydro-4,4-dimethylnaphthalen-1(2H)-one;6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one;1(2H)-Naphthalenone, 6-bromo-3,4-dihydro-4,4-dimethyl-;6-bromo-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-one
CBNumber
CB02561262
Molecular Formula
C12H13BrO
Formula Weight
253.13
MOL File
98453-60-2.mol
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6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one Property

Melting point:
48℃
Boiling point:
335℃
Density 
1.351
Flash point:
75℃
storage temp. 
Sealed in dry,Room Temperature
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0061119
Product name
6-Bromo-4,4-dimethyl-2,3-dihydronaphthalen-1-one
Packaging
100mg
Price
$207
Updated
2021/12/16
ChemScene
Product number
CS-0061119
Product name
6-Bromo-4,4-dimethyl-2,3-dihydronaphthalen-1-one
Packaging
250mg
Price
$345
Updated
2021/12/16
AK Scientific
Product number
2853AQ
Product name
6-Bromo-4,4-dimethyl-3,4-dihydro-2H-naphthalen-1-one
Packaging
250mg
Price
$479.6
Updated
2021/12/16
Alichem
Product number
98453602
Product name
6-Bromo-4,4-dimethyl-3,4-dihydronaphthalen-1(2H)-one
Packaging
100mg
Price
$186.18
Updated
2021/12/16
Crysdot
Product number
CD12000603
Product name
6-Bromo-4,4-dimethyl-3,4-dihydronaphthalen-1(2H)-one
Purity
97%
Packaging
250mg
Price
$275
Updated
2021/12/16
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6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one Chemical Properties,Usage,Production

Synthesis

98453-58-8

98453-60-2

7-Bromo-1,1-dimethyl-1,2,3,4-tetrahydronaphthalene (Compound 2, 1.1 g, 4.62 mmol) was used as a starting material and dissolved in 10 mL of dichloromethane. To this solution was added chromium (VI) oxide (72 mg, 0.46 mmol) and 5 mL of tert-butyl hydroperoxide solution (TBHP). The reaction mixture was stirred at room temperature for 8 hours. Upon completion of the reaction, the mixture was diluted with 20 mL of water and subsequently extracted with ether (3 x 10 mL). The combined organic phases were washed with brine (10 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast chromatography (eluent ratio 90:10 hexane/ethyl acetate) to afford 6-bromo-4,4-dimethyl-3,4-dihydronaphthalen-1(2H)-one (920 mg, 79% yield) as a white solid. The product was characterized by 1H NMR (CDCl3, 300 MHz): δ 7.87 (d, J = 8.1 Hz, 1H), 7.54 (d, J = 2.1 Hz, 1H), 7.42 (dd, J = 2.1, 8.1 Hz, 1H), 2.70 (dd, J = 6.3, 7.5 Hz, 2H), 2.01 (dd, J = 6.3, 7.5 Hz, 2H), 1.38 (s, 6H).

References

[1] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 13, p. 4345 - 4359
[2] Patent: WO2005/66115, 2005, A2. Location in patent: Page/Page column 19; 21
[3] Patent: US2005/148590, 2005, A1. Location in patent: Page/Page column 23; 24
[4] Tetrahedron, 1985, vol. 41, # 8, p. 1509 - 1516
[5] Patent: WO2004/46096, 2004, A2. Location in patent: Page 24

6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one Suppliers

China 26 India 1 United States 3 Global 30
Atop-Pharma (Shanghai) Technology Co., Ltd.
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+86-21-61629029
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ShangHai KenEn Chemical Technology Co., Ltd.
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13120367189
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Hangzhou J&H Chemical Co., Ltd.
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Tcichem, Inc.
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Adobe Chem Co., Ltd.
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Aikon International Limited
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98453-60-2, 6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-oneRelated Search:

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  • 98453-60-2