KX2-391

Product Name: KX2-391
CAS No.: 897016-82-9
Chemical Name: KX2-391
Synonyms: KX 01;CS-234;KX-O1);Tirbanibulin;KX2-391 (KX01);KX2-391 USP/EP/BP;Tirbanibulin, KX2-391;KX2-391（Tirbanibulin）;KX2-391;KX2 391;KX2391;N-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide
CBNumber: CB02561484
Molecular Formula: C26H29N3O3
Formula Weight: 431.53
MOL File: 897016-82-9.mol

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KX2-391 Property

Boiling point:: 680.9±55.0 °C(Predicted)
Density: 1.169
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥121 mg/mL in DMSO; ≥2.44 mg/mL in EtOH with gentle warming and ultrasonic
form: Powder
pka: 14.73±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21429
Product name: KX2-391
Purity: ≥98%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 21429
Product name: KX2-391
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 21429
Product name: KX2-391
Purity: ≥98%
Packaging: 50mg
Price: $672
Updated: 2024/03/01

Cayman Chemical

Product number: 21429
Product name: KX2-391
Purity: ≥98%
Packaging: 100mg
Price: $1151
Updated: 2024/03/01

TRC

Product number: K475000
Product name: KX2-391
Packaging: 10mg
Price: $255
Updated: 2021/12/16

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KX2-391 Chemical Properties,Usage,Production

Uses

A synthetic, orally bioavailable small molecule and non-ATP competitive Src tyrosine kinase inhibitor with an IC50 of average 72 nM.

Uses

KX2-391 is a Src Inhibitor with efficacy against certain hepatic and leukemia cell lines.

Biological Activity

kx2-391 is a highly selective inhibitor of src kinase with ic50 value of 20nm [1].kx2-391 is a non-atp competitive inhibitor of src. it is the first inhibitor that targets src kinase within the substrate binding site. kx2-391 inhibits src catalyzed trans-phosphorylation of fak, shc, paxillin as well as src kinase autophosphorylation. kx2-391 has no effects on pdgfr, egfr, jak1, jak2 and lck demonstrating it as a selective inhibitor. it is also found to be an inhibitor of tubulin polymerization through binding to the unique confirmation on heterodimeric tubulin. in cellular assays, kx2-391 shows growth inhibition in nih3t3/c-src527f cells and syf/c-src527f cells with gi50 values of 23nm and 39nm, respectively [1, 2].since src acts as a regulator in cell proliferation survival, motility and invasiveness, kx2-391 is potent against a variety of solid tumors and many leukemia tumors. it is shown to inhibit primary tumor growth and to suppress metastasis [2].

target

Src (HuH7)

References

[1] fallah-tafti a, foroumadi a, tiwari r, et al. thiazolyl n-benzyl-substituted acetamide derivatives: synthesis, src kinase inhibitory and anticancer activities. european journal of medicinal chemistry, 2011, 46(10): 4853-4858.
[2] naing a, cohen r, dy g k, et al. a phase i trial of kx2-391, a novel non-atp competitive substrate-pocket-directed src inhibitor, in patients with advanced malignancies. investigational new drugs, 2013, 31(4): 967-973.

KX2-391 Preparation Products And Raw materials

Raw materials

Preparation Products

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KX2-391 Suppliers

China 89 India 1 United States 12 Global 102

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
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Email: info@adooq.com
Country: United States
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Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
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Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
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Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
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BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
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Aladdin Scientific

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TargetMol Chemicals Inc.

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ApexBio Technology

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Cayman Chemical Company

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ProdList: 6213
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Creative Enzymes

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Country: United States
ProdList: 6057
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View Lastest Price from KX2-391 manufacturers

Career Henan Chemical Co

Product: KX2-391 897016-82-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

897016-82-9, KX2-391Related Search:

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KX 01

5-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-2-pyridineacetamide

N-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide

CS-234

KX2-391;KX2 391;KX2391

KX2-391 (KX01)

Tirbanibulin, KX2-391

Tirbanibulin

2-Pyridineacetamide, 5-[4-[2-(4-morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-

KX2-391 USP/EP/BP

N-benzyl-2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]acetamide

KX-O1)

KX2-391（Tirbanibulin）

897016-82-9

Inhibitors