(3-BroMo-pyridin-2-yl)-acetic acid ethyl ester
- Product Name
- (3-BroMo-pyridin-2-yl)-acetic acid ethyl ester
- CAS No.
- 197376-41-3
- Chemical Name
- (3-BroMo-pyridin-2-yl)-acetic acid ethyl ester
- Synonyms
- Ethyl 2-(3-Bromo-2-pyridyl)acetate;Ethyl (3-bromo-2-pyridinyl)acetate;3-Bromo-2-pyridineacetic acid ethyl ester;2-Pyridineacetic acid, 3-bromo-, ethyl ester;(3-BroMo-pyridin-2-yl)-acetic acid ethyl ester
- CBNumber
- CB02604668
- Molecular Formula
- C9H10BrNO2
- Formula Weight
- 244.09
- MOL File
- 197376-41-3.mol
(3-BroMo-pyridin-2-yl)-acetic acid ethyl ester Property
- Boiling point:
- 278℃
- Density
- 1.451
- Flash point:
- 122℃
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.05±0.22(Predicted)
- Appearance
- Light yellow to yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- HCH0045276
- Product name
- ETHYL 2-(3-BROMOPYRIDIN-2-YL)ACETATE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $212.1
- Updated
- 2021/12/16
- Product number
- HCH0045276
- Product name
- ETHYL 2-(3-BROMOPYRIDIN-2-YL)ACETATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1149.23
- Updated
- 2021/12/16
- Product number
- 0169AB
- Product name
- Ethyl2-(3-bromopyridin-2-yl)acetate
- Packaging
- 25g
- Price
- $2131
- Updated
- 2021/12/16
- Product number
- A143483
- Product name
- Ethyl2-(3-Bromo-2-pyridyl)acetate
- Purity
- 98%
- Packaging
- 25g
- Price
- $1238
- Updated
- 2021/12/16
- Product number
- A143483
- Product name
- Ethyl2-(3-Bromo-2-pyridyl)acetate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
(3-BroMo-pyridin-2-yl)-acetic acid ethyl ester Chemical Properties,Usage,Production
Synthesis
38749-79-0
105-58-8
197376-41-3
General procedure for the synthesis of ethyl 2-(3-bromo-2-pyridyl)acetate from 2-methyl-3-bromopyridine and diethyl carbonate: lithium hexamethyldisilazane (436 mL, 0.44 mmol, 1 M hexane solution) was dissolved in anhydrous ether (1 L) under nitrogen protection. 2-Methyl-3-bromopyridine (25.0 g, 0.14 mol) was slowly added and the reaction mixture was stirred at room temperature for 1 hour. Subsequently, diethyl carbonate (26.0 mL, 0.22 mol) was added dropwise and the reaction mixture continued to be stirred overnight. Upon completion of the reaction, the reaction mixture was washed three times with a half-saturated aqueous sodium chloride solution (3 x 250 mL) and the organic phase was dried with anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the residue was dissolved in hexane (200 mL). The solution was filtered through a silica gel pad (10 g) and the silica gel pad was rinsed with additional hexane (100 mL). The solvent was again concentrated under reduced pressure to remove the solvent to give the crude product. The crude product was stirred under high vacuum for 1 h to remove volatile impurities, resulting in ethyl 2-(3-bromo-2-pyridyl)acetate (37.7 g) in yellow liquid form. The molecular ion peak [M + H]+ of the product was 244.1 as analyzed by LCMS.
References
[1] Organic Letters, 2016, vol. 18, # 8, p. 1713 - 1715
[2] Synthesis, 1997, # 8, p. 949 - 952
[3] Patent: WO2014/201127, 2014, A2. Location in patent: Paragraph 00567
[4] Patent: WO2016/94710, 2016, A1. Location in patent: Paragraph 0116-0117
(3-BroMo-pyridin-2-yl)-acetic acid ethyl ester Preparation Products And Raw materials
Raw materials
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