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DECYLUBIQUINONE

Product Name
DECYLUBIQUINONE
CAS No.
55486-00-5
Chemical Name
DECYLUBIQUINONE
Synonyms
DECYLUBIQUINONE;6-decylubiquinone;Decylubiquinone (2,3-Dmdb);2,3-DIMETHOXY-5-METHYL-6-DECYL-1,4-BENZOQUINONE;2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione;2,5-Cyclohexadiene-1,4-dione, 2-decyl-5,6-dimethoxy-3-methyl-
CBNumber
CB0262439
Molecular Formula
C19H30O4
Formula Weight
322.44
MOL File
55486-00-5.mol
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DECYLUBIQUINONE Property

Boiling point:
452.9±45.0 °C(Predicted)
Density 
1.02±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 10 mg/ml)
form 
Neat yellow to orange colored oil.
color 
Yellow or orange
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D7911
Product name
Decylubiquinone
Purity
≥97% (HPLC)
Packaging
10mg
Price
$122
Updated
2024/03/01
Sigma-Aldrich
Product number
D7911
Product name
Decylubiquinone
Purity
≥97% (HPLC)
Packaging
25mg
Price
$242
Updated
2024/03/01
Cayman Chemical
Product number
21027
Product name
Decylubiquinone
Purity
≥98%
Packaging
5mg
Price
$35
Updated
2024/03/01
Cayman Chemical
Product number
21027
Product name
Decylubiquinone
Purity
≥98%
Packaging
10mg
Price
$53
Updated
2024/03/01
Sigma-Aldrich
Product number
D7911
Product name
Decylubiquinone
Purity
≥97% (HPLC)
Packaging
100mg
Price
$648
Updated
2024/03/01
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DECYLUBIQUINONE Chemical Properties,Usage,Production

Description

Decylubiquinone (55486-00-5) inhibits the Ca2+?dependent mitochondrial permeability transition pore (MPTP) without inhibiting respiration.1?Maximum effect on Ca2+?retention capacity of rat liver mitochondria at 100 μM. Inhibits etoposide-induced apoptosis in in L929 cells at 5 μM via inhibition of cytochrome C release.2?Delays rotenone-induced cardiac dysfunction in a zebrafish model of development and cardiovascular function.3?Substrate for various quinone oxidoreductases.4,5

Uses

Decylubiquinone is inhibits the Ca2+-dependent mitochondrial permeability transition pore (MPTP) and also inhibits etoposide-induced apoptosis.

Definition

ChEBI: 6-decylubiquinone is a member of the class of 1,4-benzoquinones that is 2,3-dimethoxybenzoquinone which has been substituted at positions 5 and 6 by decyl and methyl groups. It has a role as a cofactor. It is functionally related to a 6-decylubiquinol.

General Description

Ubiquinone analog.

References

1) Fontaine?et al. (1998),?A Ubiquinone-binding Site Regulates the Mitochondrial Permeability Transition Pore; J. Biol. Chem.,?273?25734 2) Karpinich?et al. (2002),?The course of Etoposide-Induced Apoptosis from Damage to DNA and p53 Activation to Mitochondrial Release of Cytochrome c; J. Biol. Chem.,?277?16547 3) Pinho?et al. (2013)?How mitochondrial dysfunction affects zebrafish development and cardiovascular function: an in vivo model for testing mitochondria-targeted drugs; Br. J. Pharmacol.,?169?1072 4) Kunow?et al.?(1994)?F420H2: quinone oxidoreductase from Archaeoglobus fulgidus. Characterization of a membrane-bound multisubunit complex containing FAD and iron-sulfur clusters; Eur. J. Biochem.,?223?503 5) Zickermann?et al?(1998)?Analysis of the pathogenic human mitochondria mutation ND1/3460 and mutations of strictly conserved residues in it’s vicinity, using the bacterium Paracoccis denitrificans; Biochemistry,?37?11792

DECYLUBIQUINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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DECYLUBIQUINONE Suppliers

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55486-00-5, DECYLUBIQUINONERelated Search:


  • 2,3-DIMETHOXY-5-METHYL-6-DECYL-1,4-BENZOQUINONE
  • 6-decylubiquinone
  • 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
  • Decylubiquinone (2,3-Dmdb)
  • DECYLUBIQUINONE
  • 2,5-Cyclohexadiene-1,4-dione, 2-decyl-5,6-dimethoxy-3-methyl-
  • 55486-00-5
  • C19H30O4