DECYLUBIQUINONE Property

Boiling point:

452.9±45.0 °C(Predicted)

Density 

1.02±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO (up to 10 mg/ml)

form 

Neat yellow to orange colored oil.

color 

Yellow or orange

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

DECYLUBIQUINONE Chemical Properties,Usage,Production

Description

Decylubiquinone (55486-00-5) inhibits the Ca2+?dependent mitochondrial permeability transition pore (MPTP) without inhibiting respiration.1?Maximum effect on Ca2+?retention capacity of rat liver mitochondria at 100 μM. Inhibits etoposide-induced apoptosis in in L929 cells at 5 μM via inhibition of cytochrome C release.2?Delays rotenone-induced cardiac dysfunction in a zebrafish model of development and cardiovascular function.3?Substrate for various quinone oxidoreductases.4,5

Uses

Decylubiquinone is inhibits the Ca2+-dependent mitochondrial permeability transition pore (MPTP) and also inhibits etoposide-induced apoptosis.

Definition

ChEBI: 6-decylubiquinone is a member of the class of 1,4-benzoquinones that is 2,3-dimethoxybenzoquinone which has been substituted at positions 5 and 6 by decyl and methyl groups. It has a role as a cofactor. It is functionally related to a 6-decylubiquinol.

General Description

Ubiquinone analog.

References

1) Fontaine?et al. (1998),?A Ubiquinone-binding Site Regulates the Mitochondrial Permeability Transition Pore; J. Biol. Chem.,?273?25734 2) Karpinich?et al. (2002),?The course of Etoposide-Induced Apoptosis from Damage to DNA and p53 Activation to Mitochondrial Release of Cytochrome c; J. Biol. Chem.,?277?16547 3) Pinho?et al. (2013)?How mitochondrial dysfunction affects zebrafish development and cardiovascular function: an in vivo model for testing mitochondria-targeted drugs; Br. J. Pharmacol.,?169?1072 4) Kunow?et al.?(1994)?F420H2: quinone oxidoreductase from Archaeoglobus fulgidus. Characterization of a membrane-bound multisubunit complex containing FAD and iron-sulfur clusters; Eur. J. Biochem.,?223?503 5) Zickermann?et al?(1998)?Analysis of the pathogenic human mitochondria mutation ND1/3460 and mutations of strictly conserved residues in it’s vicinity, using the bacterium Paracoccis denitrificans; Biochemistry,?37?11792