4-CHLORO-2,5-DIFLUOROBENZONITRILE
- Product Name
- 4-CHLORO-2,5-DIFLUOROBENZONITRILE
- CAS No.
- 135748-35-5
- Chemical Name
- 4-CHLORO-2,5-DIFLUOROBENZONITRILE
- Synonyms
- 4-CHLORO-2,5-DIFLUOROBENZONITRILE;2, 5-difluoro-4-chlorobenzonitrile;Benzonitrile, 4-chloro-2,5-difluoro-
- CBNumber
- CB0262525
- Molecular Formula
- C7H2ClF2N
- Formula Weight
- 173.55
- MOL File
- 135748-35-5.mol
4-CHLORO-2,5-DIFLUOROBENZONITRILE Property
- Boiling point:
- 206.8±35.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C7H2ClF2N/c8-5-2-6(9)4(3-11)1-7(5)10/h1-2H
- InChIKey
- OMVDTUXOHXQKML-UHFFFAOYSA-N
- SMILES
- C(#N)C1=CC(F)=C(Cl)C=C1F
- CAS DataBase Reference
- 135748-35-5(CAS DataBase Reference)
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T775673
- Product name
- 4-Chloro-2,5-difluorobenzonitrile
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-0063913
- Product name
- 4-Chloro-2,5-difluorobenzonitrile
- Purity
- 97.87%
- Packaging
- 1g
- Price
- $62
- Updated
- 2021/12/16
- Product number
- CS-0063913
- Product name
- 4-Chloro-2,5-difluorobenzonitrile
- Purity
- 97.87%
- Packaging
- 10g
- Price
- $328
- Updated
- 2021/12/16
- Product number
- 6381AA
- Product name
- 4-Chloro-2,5-difluorobenzonitrile
- Packaging
- 5g
- Price
- $331
- Updated
- 2021/12/16
- Product number
- PC902770
- Product name
- 4-Chloro-2,5-difluorobenzonitrile
- Purity
- 95%
- Packaging
- 5g
- Price
- $409
- Updated
- 2021/12/16
4-CHLORO-2,5-DIFLUOROBENZONITRILE Chemical Properties,Usage,Production
Uses
4-Chloro-2,5-difluorobenzonitrile is an organic compound that is often used as an intermediate in organic synthesis. It can participate in a variety of reactions and can also be used to prepare other organic compounds.
Synthesis
508203-26-7
135748-35-5
The general procedure for the synthesis of 4-chloro-2,5-difluorobenzonitrile from 4-chloro-2,5-difluorobenzamide was as follows: a mixture of 4-bromo-2,5-difluorobenzoic acid (11a, 53.28 g), thionyl chloride (165 mL), and N,N-dimethylformamide (DMF, 0.87 mL) was stirred for 1.5 hr at 80 °C, and subsequently cooled to room temperature. The reaction mixture was concentrated under reduced pressure and the resulting residue was dissolved in chloroform (300 mL). To this solution, 28 wt% ammonia (300 mL) was slowly added dropwise at 5 °C and stirred for 0.5 h at the same temperature. After completion of the reaction, the mixture was extracted with chloroform, the organic layers were combined and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give a pale yellow solid. The solid was mixed with phosphoryl chloride (195 mL) and stirred at 80 °C for 2 h. After completion of the reaction it was cooled to room temperature. The reaction mixture was concentrated under reduced pressure and the residue was treated with ether (500 mL) and ice water (300 mL) followed by stirring for 0.5 h at room temperature. The mixture was extracted with ether and the organic layer was washed sequentially with saturated aqueous sodium bicarbonate and brine, then dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target product 4-chloro-2,5-difluorobenzonitrile (9h, 41.57 g, 85% yield) as a light yellow solid.
References
[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 17, p. 5235 - 5246
4-CHLORO-2,5-DIFLUOROBENZONITRILE Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-CHLORO-2,5-DIFLUOROBENZONITRILE manufacturers
- Product
- 4-CHLORO-2,5-DIFLUOROBENZONITRILE 135748-35-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 4-CHLORO-2,5-DIFLUOROBENZONITRILE 135748-35-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg; 2kg；10kg; 100kg
- Release date
- 2019-08-30