BMS 201038-04
- Product Name
- BMS 201038-04
- CAS No.
- 202914-84-9
- Chemical Name
- BMS 201038-04
- Synonyms
- BMS 201038-04;AEGR733 Mesylate;AEGR 733 Mesylate;AEGR-733 Mesylate;BMS201038 Mesylate;BMS-201038 Mesylate;BMS 201038 Mesylate;LoMitapide Mesylate;BMS 201038-04 USP/EP/BP;BMS201038/LoMitapide Mesylate
- CBNumber
- CB02627605
- Molecular Formula
- C40H41F6N3O5S
- Formula Weight
- 789.8260592
- MOL File
- 202914-84-9.mol
BMS 201038-04 Property
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO:100.0(Max Conc. mg/mL);126.61(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);126.61(Max Conc. mM) - form
- Solid
- color
- White to off-white
- CAS DataBase Reference
- 202914-84-9
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H351Suspected of causing cancer
H360May damage fertility or the unborn child
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- API0013823
- Product name
- BMS-201038-04
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.41
- Updated
- 2021/12/16
- Product number
- 2522AH
- Product name
- Lomitapidemesylate
- Packaging
- 50mg
- Price
- $513
- Updated
- 2021/12/16
- Product number
- DC8428
- Product name
- LomitapideMesylate
- Purity
- >98%
- Packaging
- 250mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- DC8428
- Product name
- LomitapideMesylate
- Purity
- >98%
- Packaging
- 1g
- Price
- $1450
- Updated
- 2021/12/16
- Product number
- A615945
- Product name
- Lomitapidemesylate
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $75
- Updated
- 2021/12/16
BMS 201038-04 Chemical Properties,Usage,Production
Description
Lomitapide is an orally active microsomal triglyceride transfer protein (MTP) inhibitor for the treatment of hypercholesterolemia. The drug was developed by Aegerion Pharmaceuticals Inc. and licensed to Bristol–Myers Squibb Co. and the University of Pennsylvania. Lomitapide effectively lowered LDL–cholesterol, both as a single agent and in combination with commonly prescribed lipid-lowering therapies. Sold under the trade name Juxtapid, the drug offers a new treatment option to patients who cannot tolerate statin therapy or who experience insufficient LDL–cholesterol reduction with the currently available therapies, such as patients with homozygous familial hypercholesterolemia caused by mutations in the LDLR gene.
Definition
ChEBI: A methanesulfonate (mesylate) salt prepared from equimolar amounts of lomitapide and methanesulfonic acid. Used as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia.
Synthesis
Commercial 9H-fluorene-9-carboxylic acid (105) was alkylated with 1,4-dibromobutane in the presence of n-butyl lithium in THF to give 9-(4-bromobutyl)-9H-fluorene-9-carboxylic acid (106) in 85% yield. Next, activation of the acid as the acid chloride followed by coupling with (2,2,2-trifluoroethylamine) provided amide 107 in 71% yield for the two-step sequence. Displacement of the terminal bromide with the appropriate 4-carbamoyl piperidine followed by removal of the Boc group furnished piperidinyl fluorine 108 in high yield. Amine 108 was then reacted with the acid chloride derived from acid 109 (derived from the Suzuki coupling of boronic acid 110 and o-iodobenzoic acid 111) to give lomitapide, and this was followed by salt formation with methanesulfonic acid to afford lomitapide mesylate (XIV).
BMS 201038-04 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BMS 201038-04 manufacturers
- Product
- BMS 201038-04 202914-84-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-16
- Product
- Lomitapide Mesylate 202914-84-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-23