BMS 201038-04

Product Name: BMS 201038-04
CAS No.: 202914-84-9
Chemical Name: BMS 201038-04
Synonyms: BMS 201038-04;AEGR733 Mesylate;AEGR 733 Mesylate;AEGR-733 Mesylate;BMS201038 Mesylate;BMS-201038 Mesylate;BMS 201038 Mesylate;LoMitapide Mesylate;BMS 201038-04 USP/EP/BP;BMS201038/LoMitapide Mesylate
CBNumber: CB02627605
Molecular Formula: C40H41F6N3O5S
Formula Weight: 789.8260592
MOL File: 202914-84-9.mol

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BMS 201038-04 Property

storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO:100.0(Max Conc. mg/mL);126.61(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);126.61(Max Conc. mM)
form: Solid
color: White to off-white
CAS DataBase Reference: 202914-84-9

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H351Suspected of causing cancer

H360May damage fertility or the unborn child

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0013823
Product name: BMS-201038-04
Purity: 95.00%
Packaging: 5MG
Price: $498.41
Updated: 2021/12/16

AK Scientific

Product number: 2522AH
Product name: Lomitapidemesylate
Packaging: 50mg
Price: $513
Updated: 2021/12/16

DC Chemicals

Product number: DC8428
Product name: LomitapideMesylate
Purity: >98%
Packaging: 250mg
Price: $650
Updated: 2021/12/16

DC Chemicals

Product number: DC8428
Product name: LomitapideMesylate
Purity: >98%
Packaging: 1g
Price: $1450
Updated: 2021/12/16

Ambeed

Product number: A615945
Product name: Lomitapidemesylate
Purity: 98+%
Packaging: 5mg
Price: $75
Updated: 2021/12/16

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BMS 201038-04 Chemical Properties,Usage,Production

Description

Lomitapide is an orally active microsomal triglyceride transfer protein (MTP) inhibitor for the treatment of hypercholesterolemia. The drug was developed by Aegerion Pharmaceuticals Inc. and licensed to Bristol–Myers Squibb Co. and the University of Pennsylvania. Lomitapide effectively lowered LDL–cholesterol, both as a single agent and in combination with commonly prescribed lipid-lowering therapies. Sold under the trade name Juxtapid, the drug offers a new treatment option to patients who cannot tolerate statin therapy or who experience insufficient LDL–cholesterol reduction with the currently available therapies, such as patients with homozygous familial hypercholesterolemia caused by mutations in the LDLR gene.

Definition

ChEBI: A methanesulfonate (mesylate) salt prepared from equimolar amounts of lomitapide and methanesulfonic acid. Used as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia.

Synthesis

Commercial 9H-fluorene-9-carboxylic acid (105) was alkylated with 1,4-dibromobutane in the presence of n-butyl lithium in THF to give 9-(4-bromobutyl)-9H-fluorene-9-carboxylic acid (106) in 85% yield. Next, activation of the acid as the acid chloride followed by coupling with (2,2,2-trifluoroethylamine) provided amide 107 in 71% yield for the two-step sequence. Displacement of the terminal bromide with the appropriate 4-carbamoyl piperidine followed by removal of the Boc group furnished piperidinyl fluorine 108 in high yield. Amine 108 was then reacted with the acid chloride derived from acid 109 (derived from the Suzuki coupling of boronic acid 110 and o-iodobenzoic acid 111) to give lomitapide, and this was followed by salt formation with methanesulfonic acid to afford lomitapide mesylate (XIV).

BMS 201038-04 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS 201038-04 Suppliers

China 61 India 5 United Kingdom 1 United States 7 Global 74

A.J Chemicals

Tel: --
Fax: --
Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

GLENMARK LIFE SCIENCES LTD

Tel: --
Fax: --
Email: api.web@glenmarklifesciences.com
Country: India
ProdList: 103
Advantage: 58

MAITHRI DRUGS PRIVATE LTD

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Fax: --
Email: info@msnlabs.com
Country: India
ProdList: 29
Advantage: 58

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View Lastest Price from BMS 201038-04 manufacturers

Dideu Industries Group Limited

Product: BMS 201038-04 202914-84-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-16

Career Henan Chemical Co

Product: Lomitapide Mesylate 202914-84-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-23

202914-84-9, BMS 201038-04Related Search:

Ribavirin Lomitapide Amlodipine Levetiracetam Lithium carbonate Rivaroxaban Sodium nitrite Rubidium nitrate Tacedinaline RGFP966 RGFP 109

BMS 201038-04

LoMitapide Mesylate

BMS 201038 methanesulfonic acid salt

AEGR 733 Mesylate

AEGR733 Mesylate

AEGR-733 Mesylate

BMS 201038 Mesylate

BMS201038 Mesylate

BMS-201038 Mesylate

N-(2,2,2-trifluorethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide methanesulfonate

N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)biphenyl-2-ylcarboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide methanesulfonate

BMS201038/LoMitapide Mesylate

BMS 201038-04 USP/EP/BP

Inhibitor,Lomitapide,Lomitapide Mesylate,AEGR-733,inhibit,AEGR 733,BMS-201038,AEGR733,BMS201038,BMS 201038

N-(2,2,2-Trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide methanesulfonate[AEGR-733 Mesylate

N-(2,2,2-Trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide methanesulfonate

202914-84-9

C39H37F6N3O2xCH4O3S

C40H41F6N3O5S

Inhibitors