ChemicalBook > CAS DataBase List > VRT752271

VRT752271

Product Name: VRT752271
CAS No.: 869886-67-9
Chemical Name: VRT752271
Synonyms: CS-725;VRT752271;BVD-523FB;Padsevonil;Ulixertinib;VRT752271 HCl;BVD-523 ( VRT752271);Ulixertinib (BVD-523);Ulixertinib, VRT752271;VRT-752271(Ulixertinib)
CBNumber: CB02630104
Molecular Formula: C21H22Cl2N4O2
Formula Weight: 433.33
MOL File: 869886-67-9.mol

Less

VRT752271 Property

Boiling point:: 682.8±55.0 °C(Predicted)
Density: 1.359
storage temp.: Store at -20°C
solubility: DMSO:93.0(Max Conc. mg/mL);214.62(Max Conc. mM)
Ethanol:43.0(Max Conc. mg/mL);99.23(Max Conc. mM)
pka: 13.34±0.50(Predicted)
form: Powder
color: White to off-white
InChIKey: KSERXGMCDHOLSS-LJQANCHMSA-N
SMILES: N1C=C(C2C(Cl)=CN=C(NC(C)C)C=2)C=C1C(N[C@@H](C1=CC=CC(Cl)=C1)CO)=O

Less

Safety

HS Code: 2933998090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-2115
Product name: Ulixertinib
Purity: 99.92%
Packaging: 5mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FU157994
Product name: Ulixertinib
Packaging: 10mg
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-2115
Product name: Ulixertinib
Purity: 99.92%
Packaging: 10mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FU157994
Product name: Ulixertinib
Packaging: 25mg
Price: $125
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FU157994
Product name: Ulixertinib
Packaging: 50mg
Price: $212.5
Updated: 2021/12/16

Less

VRT752271 Chemical Properties,Usage,Production

Uses

Ulixertinib is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Inhibits cell proliferation. Anti-cancer.

Synthesis

663611-73-2

869886-90-8

869886-67-9

In step 4, a dry and clean 50 L reaction flask was first purged with nitrogen for 20 min to ensure an oxygen-free environment. Subsequently, DMF (30.20 kg) was added to the reactor and stirring was initiated. The reaction temperature was maintained in the range of 15-25 °C and ASYM-112394 (2.76 kg corrected) was slowly added until the solid was completely dissolved. Next, the reaction mixture was cooled to -10 to -20 °C and 1-hydroxybenzotriazole hydrate (2.10 kg) was added at this temperature. Then, EDCI (2.41 kg) was added in five portions at intervals of about 5-10 minutes. The mixture was further cooled to -20 to -30 °C and ASYM-111888 (1.96 kg) was added. Subsequently, DIEA (1.77kg) was added dropwise at a rate of 3-4kg/h. After completion of the addition, the temperature was increased to 15-25°C at a rate of 5-10°C/h and the reaction was maintained at this temperature. During the reaction, samples were taken at 6-8 h intervals and the level of ASYM-112394 was monitored by HPLC until it dropped below 2%. Upon completion of the reaction, the mixture was cooled to 0-10 °C and quenched with a mixture of ethyl acetate (28.80 kg) and water (12.80 kg) pre-cooled to 0-10 °C. Subsequently, the organic phase was separated by extracting with ethyl acetate (28.80 kg) three times, stirring for 20-30 minutes for each extraction and standing for 20-30 minutes. The organic phases were combined and washed twice with purified water (12.80 kg), stirred for 20-30 minutes each time and left to separate. Afterwards, the organic phase was filtered through an in-line fluid filter and the filtrate was transferred to a 300 L glass-lined reactor. The organic phase was washed twice with 5% acetic acid solution (prepared from acetic acid 2.24 kg and water 42.50 kg) at an addition rate of 10-20 kg/h. Next, the organic phase was washed twice with sodium carbonate solution (prepared from sodium carbonate 9.41 kg and water 48.00 kg), and twice with sodium chloride solution (prepared from sodium chloride 16.00 kg and water 44.80 kg). The washed organic phase was transferred to a 300 L glass-lined reactor, anhydrous sodium sulfate (9.70 kg) was added, and stirred at 15-30 °C for 2-4 hours. The mixture was filtered and the filter cake was treated with silica gel (7.50 kg) preloaded with nutche filter and washed with ethyl acetate (14.40 kg). The filtrates were combined and transferred to a 72 L flask through an in-line fluid filter and concentrated under reduced pressure (pressure -0.08 MPa) at 40 °C to a remaining 3-4 L. MTBE (4.78 kg) was added and crystallized by cooling and stirring to 0-10 °C. Samples were taken after 1 h. The percentage by weight of the mother liquor was monitored by gravimetric analysis until it reached 5% or varied by no more than 1% between successive samples. Finally, the product was collected by vacuum filtration and the filter cake was dried under nitrogen protection at 30-40°C to KF ≤ 0.5%, yielding 3.55 kg of off-white solid product with 100% purity. The product was analyzed by XRPD to confirm the structure, and the specific peak positions and intensities are shown in Tables 2 and 3 of the original article.

in vivo

In the pharmacokinetic study, the sensitivity and specificity of the assay are found to be sufficient for accurately characterizing the plasma pharmacokinetics of Ulixertinib (VRT752271) in Balb/C mice^[2].

IC 50

ERK2: 0.3 nM (IC₅₀, at K_M ATP (60 μM)); ERK1

References

[1] Patent: WO2016/123574, 2016, A1. Location in patent: Paragraph 0233; 0234; 0235; 0236
[2] Patent: WO2016/123581, 2016, A1. Location in patent: Paragraph 146; 0151; 0152; 0153; 0154
[3] Patent: WO2005/113541, 2005, A1. Location in patent: Paragraph 0089

VRT752271 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

VRT752271 Suppliers

China 148 India 2 United Kingdom 1 United States 13 Global 164

Shanghai Taibao Pharmaceutical Technology Co., Ltd.

Tel: 13816752554
Email: 1745533547@qq.com
Country: China
ProdList: 129
Advantage: 58

Kaixin Chemical (Hong Kong) Limited

Tel: 010-88886666-01 13112345678
Fax: CDXH21@126.com
Email: loyson@tcypharm.com
Country: China
ProdList: 597
Advantage: 55

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 18971495150;
Email: sales@sun-shinechem.com
Country: China
ProdList: 1077
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7782
Advantage: 58

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

Suzhou Sino Rare Chemical Co., Ltd.

Tel: 0512-62857507
Fax: +86-512-62857507
Email: sales@sinorarechem.com
Country: China
ProdList: 991
Advantage: 58

Suzhou yacoo science co.,Ltd

Tel: 0512-87182056 18013166090
Fax: 0512-87182056
Email: lingling.qi@yacoo.com.cn
Country: China
ProdList: 6295
Advantage: 60

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Shanghai XingMo Biotechnology Co., Ltd.

Tel: +86 13524779951; 13524779951
Fax: QQ: 2075692521
Email: 2075692521@qq.com
Country: China
ProdList: 298
Advantage: 55

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai YuanQi Biotechnology Co., Ltd.

Tel: +86-2332782371 +86-18120098618
Email: sales@adobechem.com
Country: China
ProdList: 1250
Advantage: 50

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 984
Advantage: 55

Nanjing Chempioneer Pharmaceutical Co., Ltd.

Tel: 18068075658
Fax: -
Email: sales@chempioneer.com
Country: China
ProdList: 1811
Advantage: 58

Guangzhou Zhiya Chemdrugs Co.,Ltd

Tel: 18122150900
Fax: QQ:2869377561
Email: sculk28@163.com
Country: China
ProdList: 646
Advantage: 55

Hui Chem Co., Ltd.

Tel: 021-34799779 18918539052
Fax: 021-61916468
Email: 1879902218@qq.com
Country: China
ProdList: 77
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2991
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29759
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
ProdList: 1844
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1944
Advantage: 55

Nanjing KaiMubo Pharmaceutical Co., Ltd.

Tel: 025-66162170
Fax: 025-66162170
Country: China
ProdList: 7181
Advantage: 55

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3931
Advantage: 58

Chemleader Biomedical Co., Limited.

Tel: 021-58180488
Fax: 021-58180499
Email: sales@MedChemLeader.com
Country: China
ProdList: 1006
Advantage: 58

Heze Development Zone chuangli Chemical Co., Ltd.

Tel: 0530-+86-530-529 6766，+86-15666160102 15666160102
Fax: 0530-529 6766
Email: info@chuangli-chem.com
Country: China
ProdList: 836
Advantage: 55

Jinan Zhixing Pharmaceutical Technology Co., Ltd.

Tel: 13853152953
Fax: -
Email: zxchem@outlook.com
Country: CHINA
ProdList: 158
Advantage: 58

Wuhan Sun-shine Bio-technology Corporation Limited

Tel: +86-027-6552-2453
Email: sales@sun-shinechem.com
Country: China
ProdList: 727
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-83778895 18602735115
Fax: 027-51119224
Email: 18602735115@163.com
Country: China
ProdList: 2005
Advantage: 64

Bejing Famous Pharmaceutical Technology Co., Ltd.

Tel: 13331045123
Fax: 86-10-80339217
Email: 2559355526@qq.com
Country: China
ProdList: 14193
Advantage: 58

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
Advantage: 58

Jinan Yaoyan Pharmaceutical Co., Ltd.

Tel
Fax: -
Email: jnyaoyan@163.com
Country: China
ProdList: 3069
Advantage: 58

Less

View Lastest Price from VRT752271 manufacturers

Career Henan Chemical Co

Product: VRT752271 869886-67-9
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-08

869886-67-9, VRT752271Related Search:

Umeclidinium bromide Methylcyclohexane 2-Methyl-4-isothiazolin-3-one Vps VS-5584 VR23

1H-Pyrrole-2-carboxaMide, 4-[5-chloro-2-[(1-Methylethyl)aMino]-4-pyridinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-

VRT752271

4-[5-Chloro-2-[(1-methylethyl)amino]-4-pyridinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide

Ulixertinib

VRT-752271(Ulixertinib)

VRT752271 HCl

4-[5-Chloro-2-[(1-methylethyl)amino]-4-pyridinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide VRT752271

Ulixertinib (BVD-523,VRT752271)

4-(5-Chloro-2-isopropylamino-4-pyridinyl)pyrrole-2-carboxylic acid (S)-[1-(3-chlorophenyl)-2-hydroxyethyl]amide HCl

Ulixertinib, VRT752271

Padsevonil

(S)-4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide

BVD-523, BVD 523, BVD523, VRT752271, VRT752271, VRT 752271, ULIXERTINIB

Ulixertinib (BVD-523)

N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-4-[5-chloro-2-(propan-2-ylamino)pyridin-4-yl]-1H-pyrrole-2-carboxamide

BVD-523 ( VRT752271)

CS-725

BVD-523; BVD 523; BVD523; ULIXERTINIB; VRT752271; VRT-752271; VRT 752271

4-[5-Chloro-2-[(1-methylethyl)amino]-4-pyridinyl]-N-[(1S)-1-...

Ulixertinib 869886-67-9

4-{5-chloro-2-[(propan-2-yl)amino]pyridin-4-yl}-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide

Ulixertinib, 10 mM in DMSO

BVD-523FB

869886-67-9

69886-67-9

C21H22Cl2N4O2

C21H22Cl2N4O2ClH