Umeclidinium bromide
- Product Name
- Umeclidinium bromide
- CAS No.
- 869113-09-7
- Chemical Name
- Umeclidinium bromide
- Synonyms
- CS-1562;UMeclidiuM;GSK573719A;Umeclidiniu;umeclidinium;Umeclinidium bromide;UMeclidiniuM broMide;Jmechlidinium bromide;Umeclidinium(GSK573719A);UMeclidiniuM BroMide (API)
- CBNumber
- CB92625301
- Molecular Formula
- C29H34BrNO2
- Formula Weight
- 508.48976
- MOL File
- 869113-09-7.mol
Umeclidinium bromide Property
- Melting point:
- >231°C (dec.)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H332Harmful if inhaled
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 20700
- Product name
- Umeclidinium (bromide)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 20700
- Product name
- Umeclidinium (bromide)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $543
- Updated
- 2024/03/01
- Product number
- 20700
- Product name
- Umeclidinium (bromide)
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $961
- Updated
- 2024/03/01
- Product number
- U710000
- Product name
- UmeclidiniumBromide
- Packaging
- 50mg
- Price
- $645
- Updated
- 2021/12/16
- Product number
- A3900
- Product name
- Umeclidiniumbromide
- Packaging
- 10mg
- Price
- $614
- Updated
- 2021/12/16
Umeclidinium bromide Chemical Properties,Usage,Production
Description
Umeclidinium bromide is a long-acting muscarinic acetylcholine antagonist developed by GlaxoSmithKline and approved by the US FDA at the end of 2013 for use in combination with vilanterol, a b2 agonist, for the treatment of chronic obstructive pulmonary disease. Due to umeclidinium’s poor oral bioavailability, the drug is administrated by inhalation as dry powder.
Uses
Umeclidinium Bromide is considered as a potentially long-acting antimuscarinic agent.
Definition
ChEBI: A quaternary ammonium salt that is the bromide salt of umeclidinium. Used in combination with vilanterol for long-term maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease.
Synthesis
Commercially available ethyl isonipecotate (278) was alkylated with 1-bromo-2-chloroethane in the presence of K2CO3 in acetone to give ethyl 1-(2-chloroethyl)piperidine-4-carboxylate (279). This material was then treated with lithium diisopropylamine (LDA) in THF to affect a transannular substitution reaction resulting in the cyclized quinuclidine 280 in 96% yield. Excess of phenyllithium was added to ester 280 in THF starting at low temperature then gradually warming to room temperature to give tertiary alcohol 281 in 61% yield. Amine 281 was finally alkylated with benzyl 2- bromoethyl ether (282) in MeCN/CHCl3 at elevated temperatures to afford umeclidinium bromide (XXXV) in 69% yield.
References
[1] salmon m, luttmann m a, foley j j, et al. pharmacological characterization of gsk573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases. journal of pharmacology and experimental therapeutics, 2013, 345(2): 260-270.
Umeclidinium bromide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Umeclidinium bromide manufacturers
- Product
- Umeclidinium bromide 869113-09-7
- Price
- US $70.00-700.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-20
- Product
- Umeclidinium Bromide 869113-09-7
- Price
- US $0.00-0.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-07-11
- Product
- Umeclidinium bromide 869113-09-7
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-16