RN486

Biological activity In vitro In vivo

Product Name: RN486
CAS No.: 1242156-23-5
Chemical Name: RN486
Synonyms: RN486;RN468;CS-689;RN486/RN-486;RN486 LM-2078;RN486 TFA Salt;RN486; RN-486; RN 486;6-Cyclopropyl-8-fluoro-2-(2-(hydroxymethyl)-3-(1-methyl-5-(5-(4-methylpiperazin-1-yl)pyridin-2;6-cyclopropyl-8-fluoro-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]-6-oxopyridin-3-yl]phenyl]isoquinolin-1-one;6-cyclopropyl-8-fluoro-2-(2-(hydroxyMethyl)-3-(1-Methyl-5-(5-(4-Methylpiperazin-1-yl)pyridin-2-ylaMino)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)isoquinolin-1(2H)-one
CBNumber: CB02650908
Molecular Formula: C35H35FN6O3
Formula Weight: 606.69
MOL File: 1242156-23-5.mol

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RN486 Property

Boiling point:: 868.6±65.0 °C(Predicted)
Density: 1.378±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥30.35 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
form: solid
pka: 13.95±0.10(Predicted)
CAS DataBase Reference: 1242156-23-5

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20536
Product name: RN-486
Purity: ≥98%
Packaging: 1mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 20536
Product name: RN-486
Purity: ≥98%
Packaging: 5mg
Price: $232
Updated: 2024/03/01

Cayman Chemical

Product number: 20536
Product name: RN-486
Purity: ≥98%
Packaging: 10mg
Price: $421
Updated: 2024/03/01

TRC

Product number: R637000
Product name: RN486
Packaging: 1mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-1814
Product name: RN486
Purity: 99.87%
Packaging: 1mg
Price: $96
Updated: 2021/12/16

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RN486 Chemical Properties,Usage,Production

Biological activity

RN486 is an effective BTK inhibitor with an IC50 of 4 nM.

In vitro

RN486 not only potently and selectively inhibits the Btk enzyme, but also displays functional activities in human cell-based assays in multiple cell types, blocking Fcε receptor cross-linking-induced degranulation in mast cells (IC50 = 2.9 nM), Fcγ receptor engagement-mediated tumor necrosis factor α production in monocytes (IC50 = 7.0 nM), and B cell antigen receptor-induced expression of an activation marker, CD69, in B cells in whole blood (IC50 = 21.0 nM). RN486 is able to block the signaling of BCR as demonstrated by a marked inhibition of phosphorylation of both Btk and PLCγ2 in B cells. RN486 displays a selective B cell inhibitory profile in BioMAP Systems.

In vivo

RN486 displays similar functional activities in rodent models, effectively preventing type I and type III hypersensitivity responses. More importantly, RN486 produces robust anti-inflammatory and bone-protective effects in mouse CIA and rat adjuvant-induced arthritis (AIA) models. In the AIA model, RN486 inhibits both joint and systemic inflammation either alone or in combination with methotrexate, reducing both paw swelling and inflammatory markers in the blood.

Uses

RN 486 is a Bruton’s tyrosine kinase (Btk) inhibitor, blocking receptor cross-linking-induced degranulation in mast cells. May be used in the prevention of arthritis and other autoimmune diseases.

RN486 Preparation Products And Raw materials

Raw materials

Preparation Products

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RN486 Suppliers

China 103 United Kingdom 1 United States 15 Global 119

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
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Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

Accendatech Co., LTD.

Tel: 13132578992
Fax: 022-83718543-802
Email: sales@accendatech.com
Country: China
ProdList: 332
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

Wuhan Kaymke Chemical Co., Ltd.,

Tel: 027-87342388 18086026008
Fax: 027-87342388
Email: sales@kaymke.com
Country: China
ProdList: 4123
Advantage: 55

MedChemexpress LLC

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Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
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TargetMol Chemicals Inc.

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Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
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CEG Chemical Science&Technology Co., Ltd.

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Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
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Email: sales@hcshhai.com
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Shanghai Qinghang Chemical Co. Ltd.

Tel: 021-50840321, 18601625411
Fax: 021-50840321
Email: thomasleehz@hotmail.com
Country: China
ProdList: 216
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View Lastest Price from RN486 manufacturers

Career Henan Chemical Co

Product: RN486 1242156-23-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: 1ton
Release date: 2019-12-18

1242156-23-5, RN486Related Search:

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RN486

6-cyclopropyl-8-fluoro-2-(2-(hydroxyMethyl)-3-(1-Methyl-5-((5-(4-Methylpiperazin-1-yl)pyridin-2-yl)aMiNA)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)isoquiNAlin-1(2H)-one

6-cyclopropyl-8-fluoro-2-(2-(hydroxyMethyl)-3-(1-Methyl-5-(5-(4-Methylpiperazin-1-yl)pyridin-2-ylaMino)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)isoquinolin-1(2H)-one

CS-689

RN486; RN-486; RN 486

RN486/RN-486

RN468

6-Cyclopropyl-2-[3-[1,6-dihydro-1-methyl-5-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-6-oxo-3-pyridinyl]-2-(hydroxymethyl)phenyl]-8-fluoro-1(2H)-isoquinolinone

RN486 LM-2078

RN486 TFA Salt

6-Cyclopropyl-8-fluoro-2-(2-(hydroxymethyl)-3-(1-methyl-5-(5-(4-methylpiperazin-1-yl)pyridin-2

6-cyclopropyl-8-fluoro-2-(2-(hydroxymethyl)-3-(1-methyl-5-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)isoquinolin-1(2H)-on

6-cyclopropyl-8-fluoro-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]-6-oxopyridin-3-yl]phenyl]isoquinolin-1-one

2-(3-(5-(5-(4-methylpiperazin-1-yl)pyridin-2-ylamino)-1,6-dihydro-1-methyl-6-oxopyridin-3-yl)-2-(hydroxymethyl)phenyl)-6-cyclopropyl-8-fluoroisoquinolin-1(2H)-one

1(2H)-Isoquinolinone, 6-cyclopropyl-2-[3-[1,6-dihydro-1-methyl-5-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-6-oxo-3-pyridinyl]-2-(hydroxymethyl)phenyl]-8-fluoro-

1242156-23-5

C35H35FN6O3

Inhibitors