RKI1447

Product Name: RKI1447
CAS No.: 1342278-01-6
Chemical Name: RKI1447
Synonyms: RKI-1447;RKI 1447;CS-855;RKI1447;RKI-1447, >=98%;RKI 1447; RKI1447;RKI1447 USP/EP/BP;7-Pentahydroxyflavone;1-(3-HYDROXYBENZYL)-3-(4-(PYRIDIN-4-YL)THIAZOL-2-YL)UREA;RKI-1447, 98%, a potent small molecule inhibitor of ROCK1 and ROCK2
CBNumber: CB42660015
Molecular Formula: C16H14N4O2S
Formula Weight: 326.37
MOL File: 1342278-01-6.mol

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RKI1447 Property

Melting point:: >205oC (dec.)
Density: 1.408±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
pka: 6.36±0.70(Predicted)
form: Solid
color: Pale Yellow to Pale Beige
InChI: InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)
InChIKey: GDVRVPIXWXOKQO-UHFFFAOYSA-N
SMILES: N(CC1=CC=CC(O)=C1)C(NC1=NC(C2C=CN=CC=2)=CS1)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16278
Product name: RKI-1447
Purity: ≥98%
Packaging: 5mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 16278
Product name: RKI-1447
Purity: ≥98%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 16278
Product name: RKI-1447
Purity: ≥98%
Packaging: 50mg
Price: $422
Updated: 2024/03/01

TRC

Product number: R550000
Product name: RKI-1447
Packaging: 100mg
Price: $875
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181117
Product name: RKI-1447
Purity: >98%
Packaging: 250mg
Price: $1356.6
Updated: 2021/12/16

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RKI1447 Chemical Properties,Usage,Production

Description

RKI-1447 is an inhibitor of the Rho-associated kinases ROCK1 and 2 (IC₅₀s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase. In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2 and the MLC phosphatase PP1 regulatory subunit MYPT1 without effect on the phosphorylation of Akt, MEK, or S6 kinase. Furthermore, it can prevent ROCK-mediated migration, invasion, and anchorage-independent growth of MDA-MB-231 breast cancer cells (IC₅₀ = 709 nM).

Uses

RKI-1447 is a potent and selective ROCK1 and ROCK2 inhibitor with significant anti-invasive and anti-tumor activies.

References

[1] patel r a et al. , rki-1447 is a potent inhibitor of the rho-associated rock kinases with anti-invasive and antitumor activities in breast cancer. cancer res, 2012, 72(19): 5025-5034.

RKI1447 Preparation Products And Raw materials

Raw materials

Preparation Products

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RKI1447 Suppliers

China 87 France 1 India 2 United States 16 Global 106

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
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Dalian Meilun Biotech Co., Ltd.

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Shanghai Topbiochem Technology Co., Ltd

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Haoyuan Chemexpress Co., Ltd.

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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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MedChemexpress LLC

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View Lastest Price from RKI1447 manufacturers

Career Henan Chemical Co

Product: RKI1447 1342278-01-6
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-09-03

1342278-01-6, RKI1447Related Search:

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CS-855

RKI 1447; RKI1447

RKI 1447

RKI1447

RKI-1447

1-(3-HYDROXYBENZYL)-3-(4-(PYRIDIN-4-YL)THIAZOL-2-YL)UREA

Urea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]-

1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea RKI 1447

RKI 1447 1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea

RKI-1447, >=98%

RKI-1447, 98%, a potent small molecule inhibitor of ROCK1 and ROCK2

1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea

RKI1447 USP/EP/BP

7-Pentahydroxyflavone

1342278-01-6

Inhibitors