RKI1447
- Product Name
- RKI1447
- CAS No.
- 1342278-01-6
- Chemical Name
- RKI1447
- Synonyms
- RKI-1447;RKI 1447;CS-855;RKI1447;RKI-1447, >=98%;RKI 1447; RKI1447;RKI1447 USP/EP/BP;7-Pentahydroxyflavone;1-(3-HYDROXYBENZYL)-3-(4-(PYRIDIN-4-YL)THIAZOL-2-YL)UREA;RKI-1447, 98%, a potent small molecule inhibitor of ROCK1 and ROCK2
- CBNumber
- CB42660015
- Molecular Formula
- C16H14N4O2S
- Formula Weight
- 326.37
- MOL File
- 1342278-01-6.mol
RKI1447 Property
- Melting point:
- >205oC (dec.)
- Density
- 1.408±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- pka
- 6.36±0.70(Predicted)
- form
- Solid
- color
- Pale Yellow to Pale Beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 16278
- Product name
- RKI-1447
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 16278
- Product name
- RKI-1447
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 16278
- Product name
- RKI-1447
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $422
- Updated
- 2024/03/01
- Product number
- R550000
- Product name
- RKI-1447
- Packaging
- 100mg
- Price
- $875
- Updated
- 2021/12/16
- Product number
- orb181117
- Product name
- RKI-1447
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1356.6
- Updated
- 2021/12/16
RKI1447 Chemical Properties,Usage,Production
Description
RKI-1447 is an inhibitor of the Rho-associated kinases ROCK1 and 2 (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase. In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2 and the MLC phosphatase PP1 regulatory subunit MYPT1 without effect on the phosphorylation of Akt, MEK, or S6 kinase. Furthermore, it can prevent ROCK-mediated migration, invasion, and anchorage-independent growth of MDA-MB-231 breast cancer cells (IC50 = 709 nM).
Uses
RKI-1447 is a potent and selective ROCK1 and ROCK2 inhibitor with significant anti-invasive and anti-tumor activies.
References
[1] patel r a et al. , rki-1447 is a potent inhibitor of the rho-associated rock kinases with anti-invasive and antitumor activities in breast cancer. cancer res, 2012, 72(19): 5025-5034.
RKI1447 Preparation Products And Raw materials
Raw materials
Preparation Products
RKI1447 Suppliers
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View Lastest Price from RKI1447 manufacturers
- Product
- RKI1447 1342278-01-6
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-09-03