ChemicalBook > CAS DataBase List > 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide

Product Name
2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
CAS No.
946387-07-1
Chemical Name
2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
Synonyms
PM-0016;RN 1734;RN-1734 ，S2650;RN-1734 (RN1734;RN-1734, 10 mM in DMSO;RN-1734, TRPV4 antagonist;TRPV4 Antagonist I, RN-1734;TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem;2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide;2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide
CBNumber
CB11529521
Molecular Formula
C14H22Cl2N2O2S
Formula Weight
353.31
MOL File
946387-07-1.mol
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2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Property

storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
form 
Yellow solid
color 
white to off-white
InChI
1S/C14H22Cl2N2O2S/c1-10(2)17-7-8-18(11(3)4)21(19,20)14-6-5-12(15)9-13(14)16/h5-6,9-11,17H,7-8H2,1-4H3
InChIKey
IHYZMEAZAIFMTN-UHFFFAOYSA-N
SMILES
ClC1=C(S(N(C(C)C)CCNC(C)C)(=O)=O)C=CC(Cl)=C1
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Safety

WGK Germany 
nwg
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R0658
Product name
RN-1734
Purity
≥98% (HPLC)
Packaging
5mg
Price
$92.7
Updated
2026/03/19
Sigma-Aldrich
Product number
616520
Product name
TRPV4 Antagonist I, RN-1734
Packaging
10mg
Price
$104
Updated
2026/03/19
Cayman Chemical
Product number
24205
Product name
RN-1734
Purity
≥98%
Packaging
5mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
24205
Product name
RN-1734
Purity
≥98%
Packaging
10mg
Price
$95
Updated
2024/03/01
Sigma-Aldrich
Product number
R0658
Product name
RN-1734
Purity
≥98% (HPLC)
Packaging
25mg
Price
$369
Updated
2026/03/19
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2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Chemical Properties,Usage,Production

Uses

RN 1734 is a novel TRPV4 modulator.

Uses

RN-1734 has been used as a transient receptor potential vanilloid 4 (TRPV4) blocker to study its effects on differentiation of a corneal epithelial cell model, RCE1(5T5) cells.

General Description

A cell-permeable benzenesulfonamide compound that acts as a selective TRPV4 antagonist and inhibits TRPV4 agonist 4α-PDD- (Cat. No. 524394) stimulated Ca2+ influx (IC50 = 2.3, 3.2 and 5.9 μM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- (Cat. No. 211275) activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC50 >30 μM).

Biological Activity

Selective TRPV4 antagonist (IC 50 values are 2.3, 5.9 and 3.2 μ M for hTRPV4, mTRPV4 and rTRPV4 receptors respectively). Displays selectivity for over other TRP channels (IC 50 values are 2.3, >30, >30 and >100 μ M for TRPV4, TRPV3, TRPM8 and TRPV1 respectively).

Biochem/physiol Actions

RN-1734 is a selective TRPV4 antagonist.

storage

+4°C

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Suppliers

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946387-07-1, 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamideRelated Search:

5-METHYL-N,N-DIMETHYLTRYPTAMINE Cumene N-Isopropylacrylamide N-Isopropylbenzylamine N-Methyl-2-pyrrolidone RN-1 (hydrochloride) RKI1447 RN486

  • 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
  • RN 1734
  • 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulphonamide (RN-1734)
  • 2,4-Dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide
  • TRPV4 Antagonist I, RN-1734
  • TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem
  • 2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide
  • Benzenesulfonamide, 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]-
  • RN-1734 (2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide)
  • PM-0016
  • RN1734,Inhibitor,RN-1734,Transient receptor potential channels,TRP Channel,inhibit,RN 1734
  • RN-1734, TRPV4 antagonist
  • RN-1734, 10 mM in DMSO
  • RN-1734 (RN1734
  • RN-1734 ，S2650
  • 946387-07-1